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Insulin-like peptide 3 (INSL3) is a peptide hormone belonging to the insulin/relaxin superfamily, which mediates testes descent in the male fetus, and suppresses male germ cell apoptosis and promotes oocyte maturation in adults by activating the leucine-rich repeat-containing G-protein coupled receptor RXFP2. In a previous work, we prepared mature two-chain INSL3 by recombinant expression of a designed...
Insulin-like peptide 6 (INSL6) is a newly identified peptide hormone belonging to the insulin/relaxin superfamily. It is predominantly expressed in the testes and responsible for spermatogenesis. It also shows potential for the treatment of benign prostate hyperplasia. For further basic and preclinical studies, significant quantities of INSL6 peptide are needed. In the present work, we designed and...
Relaxin-3 (also known as INSL7) is the most recently identified member of the insulin-like family. It is predominantly expressed in the nucleus incertus of the brain and involved in the control of stress response, food intake, and reproduction. In the present work, we have established a simple approach for the preparation of the mature human relaxin-3 peptide. We first designed and recombinantly expressed...
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