Search results for: Poppy Datta

Items from 1 to 8 out of 8 results

article

Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA: Effects of aminophospholipids and cholesterol

Poppy Datta, Sudipa Chakrabarty, Amit Chakrabarty, Abhijit Chakrabarti

BBA - Biomembranes > 2008 > 1778 > 1 > 1-9

The interaction of hemoglobin with phospholipid bilayer vesicles (liposomes) has been analyzed in several studies to better understand membrane–protein interactions. However, not much is known on hemoglobin interactions with the aminophospholipids, predominantly localized in the inner leaflet of erythrocytes, e.g., phosphatidylserine (PS), phosphatidylethanolamine (PE) in membranes containing phosphatidylcholine...

article

Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of αA- and αB-crystallins

Edathara C. Abraham, Jin Huaqian, Atya Aziz, Anbarasu Kumarasamy, more

Molecular and Cellular Biochemistry > 2008 > 310 > 1-2 > 235-239

Earlier studies have shown significant loss of chaperone activity in α-crystallin from diabetic lenses. In vitro glycation studies have suggested that glycation of α-crystallin could be the major cause of chaperone activity loss. The following lysine (K) residues in α-crystallin have been identified as the major glycation sites: K11, K78, and K166 in αA-crystallin and K90, K92, and K166 in αB-crystallin...

article

Reversal of chaperone activity loss of glycated αA-crystallin by a crosslink breaker

Poppy Datta, Latha Kallur, Edathara C. Abraham

Molecular and Cellular Biochemistry > 2008 > 315 > 1-2 > 137-142

The chaperone function of α-crystallin is significantly affected in diabetes. Increased formation of advanced glycation end products (AGEs) is the likely cause. This study was aimed to investigate the effect of AGE crosslinks on the chaperone activity of α-crystallin and to show the effect of an AGEs crosslink breaker, phenacyl-4,5-dimethylthiazolium bromide (DMPTB). Recombinant αA-crystallin was...

article

Spectrin interactions with globin chains in the presence of phosphate metabolites and hydrogen peroxide: implications for thalassaemia

Poppy Datta, Sudipa Chakrabarty, Amit Chakrabarty, Abhijit Chakrabarti

Journal of Biosciences > 2007 > 32 > 2 > 1147-1151

We have shown the differential interactions of the erythroid skeletal protein spectrin with the globin subunits of adult haemoglobin (HbA); these indicate a preference for α-globin over that for β-globin and intact HbA in an adenosine 5′-triphosphate (ATP)-dependent manner. The presence of Mg/ATP led to an appreciable decrease in the binding affinity of the α-globin chain to spectrin and the overall...

article

Enhanced oxidative cross-linking of hemoglobin E with spectrin and loss of erythrocyte membrane asymmetry in hemoglobin Eβ-thalassemia

Poppy Datta, Sumanta Basu, Sudipa Basu Chakravarty, Amit Chakravarty, more

Blood Cells, Molecules and Diseases > 2006 > 37 > 2 > 77-81

Oxidative stress to the erythrocytes is associated with formation of large molecular complexes of hemoglobin and the skeletal protein, spectrin. In this work, such complexes are formed with hemoglobin mixtures isolated from patients suffering from HbEβ-thalassemia with elevated levels of the HbE and purified erythroid spectrin in the presence of hydrogen peroxide. The complexes are separated on 4%...

article

Crystal Structures of HbA ₂ and HbE and Modeling of Hemoglobin δ ₄ : Interpretation of the Thermal Stability and the Antisickling Effect of HbA ₂ and Identification of the Ferrocyanide Binding Site in Hb ^‡

Udayaditya Sen, Jhimli Dasgupta, Debi Choudhury, Poppy Datta, more

Biochemistry > 2004 > 43 > 39 > 12477 - 12488

article

Interaction of erythroid spectrin with hemoglobin variants: implications in β-thalassemia

Poppy Datta, Sudipa Basu Chakrabarty, Amit Chakrabarty, Abhijit Chakrabarti

Blood Cells, Molecules and Diseases > 2003 > 30 > 3 > 248-253

Among the few studies, producing contradictory results, done on the interaction of erythroid membrane skeletal spectrin with hemoglobin (Hb), none has been able to provide a quantitative estimate of the association of spectrin with Hb. In this work, studies on the interactions of erythroid spectrin with Hb have been elaborated upon using a novel fluorescence technique. The concentration-dependent...

article

Crystallization and preliminary X-ray structural studies of hemoglobin A ₂ and hemoglobin E, isolated from the blood samples of β-thalassemic patients

Jhimli Dasgupta, Udayaditya Sen, Debi Choudhury, Poppy Datta, more

Biochemical and Biophysical Research Communications > 2003 > 303 > 2 > 619-623

Hemoglobin A ₂ (α ₂ δ ₂ ), a minor (2-3%) component of circulating red blood cells, acts as an anti-sickling agent and its elevated concentration in β-thalassemia is a useful clinical diagnostic. In β-thalassemia major, where there is a failure of β-chain production, HbA ₂ acts as the predominant oxygen deliverer. Hemoglobin E, is another common abnormal hemoglobin,...

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