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Neurodegenerative disorders are characterized by the formation of protein oligomers and amyloid fibrils, which in the case of Parkinson’s disease involves the protein α‐synuclein (αSN). Cytotoxicity is mainly associated with the oligomeric species, but we still know little about their assembly and structure. Hydrogen/deuterium exchange (HDX) monitored by mass spectrometry is used to analyze oligomers...
α‐Synuclein‐Oligomere werden allgemein als zytotoxische Spezies in der Parkinson‐Krankheit angesehen – es wird aber diskutiert, ob sie ein Zwischenprodukt der Fibrillenbildung oder das Endprodukt der Aggregation sind. In ihrer Zuschrift auf S. 7690 ff. zeigen D. Otzen, T. J. D. Jørgensen und Mitarbeiter, dass beide Annahmen zutreffen und dass zwei Arten von α‐Synuclein‐Oligomeren existieren: eine,...
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