Search results for: Stefan Rose-John

Items from 1 to 20 out of 214 results

article

Mechanisms of interorgan crosstalk in health and disease

Andreas Herrlich, Eirini Kefaloyianni, Stefan Rose‐John

FEBS Letters > 596 > 5 > 529 - 533

article

Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer

Stefan Rose‐John

FEBS Letters > 596 > 5 > 557 - 566

Interleukin‐6 (IL‐6) is an inflammatory cytokine, the level of which is highly elevated in most, if not all, inflammatory states. IL‐6 triggers cell type‐specific responses and acts on target cells via a specific interleukin‐6 receptor (IL‐6R), which, together with IL‐6, binds to and induces the dimerization of a second receptor subunit, gp130. IL‐6 also binds to soluble IL‐6R, and this complex interacts...

article

Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA

Anibal Garza Carbajal, Andrea Ebersberger, Alina Thiel, Luiz Ferrari, more

Journal of Neurochemistry > 157 > 6 > 1821 - 1837

Hyperalgesic priming is characterized by enhanced nociceptor sensitization by pronociceptive mediators, prototypically PGE₂. Priming has gained interest as a mechanism underlying the transition to chronic pain. Which stimuli induce priming and what cellular mechanisms are employed remains incompletely understood. In adult male rats, we present the cytokine Oncostatin M (OSM), a member of the IL‐6...

article

Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

Andreas Reif, Kevin Lam, Sascha Weidler, Marie Lott, more

Angewandte Chemie International Edition > 60 > 24 > 13380 - 13387

A library of glycoforms of human interleukin 6 (IL‐6) comprising complex and mannosidic N‐glycans was generated by semisynthesis. The three segments were connected by sequential native chemical ligation followed by two‐step refolding. The central glycopeptide segments were assembled by pseudoproline‐assisted Lansbury aspartylation and subsequent enzymatic elongation of complex N‐glycans. Nine IL‐6...

article

Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

Andreas Reif, Kevin Lam, Sascha Weidler, Marie Lott, more

Angewandte Chemie > 133 > 24 > 13492 - 13499

article

Correction to: A new multiple trauma model of the mouse

Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, more

BMC Musculoskeletal Disorders > 2019 > 20 > 1 > 1-10

After publication of the original article [1], it was noticed that the following corrections needed to be implemented.

article

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma

Kathrin Kaiser, Katja Prystaz, Anna Vikman, Melanie Haffner-Luntzer, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2018 > 391 > 5 > 523-536

Patients with multiple injuries frequently suffer bone fractures and are at high risk to develop fracture healing complications. Because of its key role both in systemic posttraumatic inflammation and fracture healing, the pleiotropic cytokine interleukin-6 (IL-6) may be involved in the pathomechanisms of trauma-induced compromised fracture healing. IL-6 signals are transmitted by two different mechanisms:...

article

Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing

Katja Prystaz, Kathrin Kaiser, Anna Kovtun, Melanie Haffner-Luntzer, more

The American Journal of Pathology > 2018 > 188 > 2 > 474-490

Bone healing is a complex process with closely linked phases of inflammation, regeneration, and remodeling. IL-6 may crucially regulate this process; however, the underlying mechanisms are unclear. IL-6 signals are transmitted via the transmembrane glycoprotein 130 by two distinct mechanisms: classic signaling using the membrane-anchored IL-6 receptor and trans-signaling using its soluble form. Herein,...

article

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, more

Cell Reports > 2017 > 21 > 8 > 2090-2103

The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth. To gain access to the cleavage site in MUC2, meprin β must be proteolytically shed from epithelial cells. Hence, regulation of meprin β shedding and activation is important for physiological and pathophysiological conditions. Here, we demonstrate that...

article

A new multiple trauma model of the mouse

Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, more

BMC Musculoskeletal Disorders > 2017 > 18 > 1 > 1-12

Background Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest trauma and extremity fracture. Several trauma mouse models combine chest trauma and head injury, but no trauma mouse model to date includes the combination of long bone fractures and...

article

The shedding protease ADAM17: Physiology and pathophysiology

Friederike Zunke, Stefan Rose-John

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2017 > 1864 > 11(PB) > 2059-2070

The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to unravel structure, function and regulation of protease expression, maturation and activity. In this review, we summarize data on the physiological role of ADAM17 in health and disease. Here we provide an overview of ADAM17 substrates, mouse models of ADAM17-deficiencies and discuss recent findings of ADAM17 function...

article

Proteolytic steps within signaling cascades make these signaling pathways irreversible

Stefan Rose-John

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2017 > 1864 > 11(PB) > 2057-2058

article

Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice

Jan Tode, Elisabeth Richert, Stefan Koinzer, Alexa Klettner, more

Cytokine > 2017 > 96 > C > 8-15

To evaluate the effect of an intravitreally applied anti-IL-6 antibody for the treatment of experimental autoimmune uveitis (EAU).EAU was induced in female B10.RIII mice by Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund’s adjuvant, boosted by Pertussis toxin. Single blinded intravitreal injections of anti-IL-6 antibody were applied 5–7days as well as 8–10days (3day interval) after EAU...

article

Interleukin 6 trans‐signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole‐induced seizures in mice

Roberto Cuevas‐Olguin, Eric Esquivel‐Rendon, Jorge Vargas‐Mireles, Francisco Garcia‐Oscos, more

Synapse > 71 > 9 > n/a - n/a

The pro‐inflammatory cytokine interleukin 6 (IL‐6) interacts with the central nervous system in a largely unknown manner. We used a genetically modified mouse strain (GFAP‐sgp130Fc, TG) and wild type (WT) mice to determine whether IL‐6 trans‐signaling contributes to basal properties of synaptic transmission. Postsynaptic currents (PSCs) were studied by patch‐clamp recording in cortical layer 5 of...

article

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Sriram Srivatsa, Mariel C. Paul, Claudia Cardone, Martin Holcmann, more

Gastroenterology > 2017 > 153 > 1 > 178-190.e10

Inhibitors of the epidermal growth factor receptor (EGFR) are the first-line therapy for patients with metastatic colorectal tumors without RAS mutations. However, EGFR inhibitors are ineffective in these patients, and tumor level of EGFR does not associate with response to therapy. We screened human colorectal tumors for EGFR-positive myeloid cells and investigated their association with patient...

article

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2

Michaela Wittlich, Michael Dudek, Jan P. Böttcher, Oliver Schanz, more

Journal of Hepatology > 2017 > 66 > 5 > 978-986

Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient Granzyme B (GzmB) expression. Here we provide evidence for a so far unrecognized CD4 T helper cell...

article

Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis

Tali Lanton, Anat Shriki, Yael Nechemia‐Arbely, Rinat Abramovitch, more

Hepatology > 65 > 5 > 1600 - 1611

Liver cancer, which typically develops on a background of chronic liver inflammation, is now the second leading cause of cancer mortality worldwide. For patients with liver cancer, surgical resection is a principal treatment modality that offers a chance of prolonged survival. However, tumor recurrence after resection, the mechanisms of which remain obscure, markedly limits the long‐term survival...

article

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

Katharina Timper, Jesse Lee Denson, Sophie Marie Steculorum, Christian Heilinger, more

Cell Reports > 2017 > 19 > 2 > 267-280

Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find that central application of IL-6 in mice suppresses feeding and improves glucose tolerance. In contrast to leptin, whose action is attenuated in obesity, the ability of IL-6 to suppress feeding is enhanced in obese mice. IL-6 suppresses feeding in the absence of neuronal IL-6-receptor (IL-6R) expression in hypothalamic...

article

The balance between Treg and TH₁₇ cells: CD11b and interleukin‐6

Christoph Garbers, Stefan Rose‐John

European Journal of Immunology > 47 > 4 > 629 - 632

One of the gold standards for animal models of rheumatoid arthritis is the murine collagen‐induced arthritis model. Native type II collagen together with CFA is injected into susceptible mouse strains. Unfortunately, only mice with H‐2^q or H‐2^r MHC haplotypes are susceptible, making the widely used C57BL/6 mouse strain, which carries the H‐2^b haplotype, resistant against the disease. In this issue...

article

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling

Jesse J. Balic, Christoph Garbers, Stefan Rose-John, Liang Yu, more

Cytokine > 2017 > 92 > Complete > 118-123

Deregulated gp130-dependent STAT3 signalling by the pleiotropic cytokine interleukin (IL)-11 has been implicated in the pathogenesis of gastric cancer (GC), the third most common cancer worldwide. While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound IL-11 receptor (mIL-11R), recent evidence suggests that mIL-11R can be proteolytically cleaved...

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INFONA - science communication portal

Search results for: Stefan Rose-John

Mechanisms of interorgan crosstalk in health and disease

Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer

Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA

Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

Correction to: A new multiple trauma model of the mouse

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma

Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

A new multiple trauma model of the mouse

The shedding protease ADAM17: Physiology and pathophysiology

Proteolytic steps within signaling cascades make these signaling pathways irreversible

Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice

Interleukin 6 trans‐signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole‐induced seizures in mice

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2

Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

The balance between Treg and TH₁₇ cells: CD11b and interleukin‐6

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling

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