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The breast and ovarian cancer suppressor BRCA1 is essential for cellular responses to DNA damage [1]. It heterodimerizes with BARD1 to acquire an E3 ubiquitin (Ub) ligase activity that is often compromised by cancer-associated mutations [2]. Neither the significance of this activity to damage responses, nor a relevant in vivo substrate, is clear.We have separated DNA-damage responses requiring the...
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