Search results for: Thomas Hays

Items from 1 to 9 out of 9 results

article

The utility of gene sequencing in identifying an underlying genetic disorder in prenatally suspected lower urinary tract obstruction

Bobby K. Brar, Karin Blakemore, Christine Hertenstein, Jena L. Miller, more

Objective Fetal megacystis generally presents as suspected lower urinary tract obstruction (LUTO), which is associated with severe perinatal morbidity. Genetic etiologies underlying LUTO or a LUTO—like initial presentation are poorly understood. Our objectives are to describe single gene etiologies in fetuses initially ascertained to have suspected LUTO and to elucidate genotype‐phenotype correlations...

article

Flexural strength and flaw distributions of SrFe_0.2Co_0.4Mo_0.4O_3−δ ceramic‐supports for SOFCs at operating conditions

Patrick Stanley, Abdul Mohammed Hussain, Thomas Hays, Ian Robinson, more

Journal of the American Ceramic Society > 102 > 12 > 7606 - 7616

Solid‐oxide fuel cells (SOFCs) have the potential to increase electricity generation efficiency, but traditional SOFCs supported by nickel cermets suffer from reliability challenges due to weaker mechanical strength caused by cracking after redox cycling. To solve this problem, a new ceramic anode material, SrFe_0.2Co_0.4Mo_0.4O_3−δ (SFCM) combined with Ce_0.9Gd_0.1O₂ (GDC), was evaluated for conductivity...

article

High temperature mechanical behavior of porous ceria and ceria‐based solid‐oxide fuel cells

Patrick Stanley, Thomas Hays, Tom Langdo, Colin Gore, more

Journal of the American Ceramic Society > 102 > 9 > 5565 - 5575

Multiple environment mechanical testing of solid‐oxide fuel cells (SOFCs) and SOFC materials is critical to ensure appropriate compressive sealing in stack designs. Establishing the effects of temperature, environment, and porosity on the flexural strength of ceria‐based SOFCs is a significant step toward practical deployment of the technology. This article presents research into these properties...

article

Exploratory laparoscopy for rotational abnormality of the intestine in a child with leukocyte adhesion deficiency type II

Thomas Hays, Elizabeth Feuille, Edith Schussler, Charlotte Cunningham-Rundles, more

Journal of Pediatric Surgery Case Reports > 2013 > 1 > 8 > 244-246

Leukocyte adhesion deficiency type II (LAD II) is a rare immunodeficiency that causes frequent, recurrent infections and impaired wound healing. Here we report a case of a patient with LAD II who presented with failure to thrive and abdominal pain, for which underwent exploratory laparoscopy and gastrostomy tube placement. No previous cases of a patient with LAD II undergoing surgery have been reported...

article

An exact approach for studying cargo transport by an ensemble of molecular motors

Donatello Materassi, Subhrajit Roychowdhury, Thomas Hays, Murti Salapaka

BMC Biophysics > 2013 > 6 > 1 > 1-18

Background Intracellular transport is crucial for many cellular processes where a large fraction of the cargo is transferred by motor-proteins over a network of microtubules. Malfunctions in the transport mechanism underlie a number of medical maladies. Existing methods for studying how motor-proteins coordinate the transfer of a shared cargo over a microtubule are either analytical or are based on...

article

Detection of Steps in Single Molecule Data

Tanuj Aggarwal, Donatello Materassi, Robert Davison, Thomas Hays, more

Cellular and Molecular Bioengineering > 2012 > 5 > 1 > 14-31

Over the past few decades, single molecule investigations employing optical tweezers, AFM and TIRF microscopy have revealed that molecular behaviors are typically characterized by discrete steps or events that follow changes in protein conformation. These events, that manifest as steps or jumps, are short-lived transitions between otherwise more stable molecular states. A major limiting factor in...

article

Genomic Identification of Potential Risk Factors during Acetaminophen-Induced Liver Disease in Susceptible and Resistant Strains of Mice

Kevin D. Welch, Timothy P. Reilly, Mohammed Bourdi, Thomas Hays, more

Chemical Research in Toxicology > 2006 > 19 > 2 > 223 - 233

article

In Vivo Dynamics of the Rough Deal Checkpoint Protein during Drosophila Mitosis

Renata Basto, Frédéric Scaerou, Sarah Mische, Edward Wojcik, more

Current Biology > 2004 > 14 > 1 > 56-61

Rough Deal (Rod) and Zw10 are components of a complex required for the metazoan metaphase checkpoint [1, 2] and for recruitment of dynein/dynactin to the kinetochore [3]. The Rod complex, like most classical metaphase checkpoint components, forms part of the outer domain of unattached kinetochores. Here we analyze the dynamics of a GFP-Rod chimera in living syncytial Drosophila embryos. Uniquely among...

article

Interactions of Cytoplasmic Dynein Light Chains Tctex-1 and LC8 with the Intermediate Chain IC74 ^†

Moses Makokha, Michael Hare, Mingang Li, Thomas Hays, more

Biochemistry > 2002 > 41 > 13 > 4302 - 4311

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