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The agonistic Jo2 anti-Fas antibody reproduces human fulminant hepatitis in mice. We tested the hypothesis that enhancing hepatic glutathione (GSH) stores may prevent Jo2-induced apoptosis.We fed mice with a normal diet or a sulfur amino acid-enriched (SAA + ) diet increasing hepatic GSH by 63%, and challenged these mice with Jo2.The SAA + diet markedly attenuated the Jo2-mediated...
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