Search results for: Nancy L. Wengenack

Items from 1 to 18 out of 18 results

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Temporal trends in antifungal susceptibility of Cryptococcus neoformans isolates from a reference laboratory in the United States, 2011–2021

Eloy E. Ordaya, Omar M. Abu Saleh, Paschalis Vergidis, Sharon M. Deml, more

Mycoses > 67 > 1 > n/a - n/a

Background There are no established clinical breakpoints for antifungal agents against Cryptococcus species; however, epidemiological cut‐off values can help distinguish wild‐type (WT) isolates without any acquired resistance from non‐WT strains, which may harbour resistance mechanisms. Patients/Methods We describe the trends of antifungal MICs and percentages of WT C. neoformans species complex...

article

Outcomes of transplant recipients with pretransplant Nocardia colonization or infection

Zachary A. Yetmar, Supavit Chesdachai, Ryan B. Khodadadi, Jack W. McHugh, more

Transplant Infectious Disease > 25 > 5 > n/a - n/a

Background Specific pretransplant infections have been associated with poor posttransplant outcomes. However, the impact of pretransplant Nocardia isolation has not been studied. Methods We performed a retrospective study from three centers in Arizona, Florida, and Minnesota of patients with Nocardia infection or colonization who subsequently underwent solid organ or hematopoietic stem cell transplantation...

article

An 82‐year‐old man with a right frontal lobe rim‐enhancing lesion

Kyriakos Chatzopoulos, Kathryn L. Eschbacher, Pooja R. Gurram, Jeffrey Huang, more

Brain Pathology > 32 > 2 > n/a - n/a

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Eighty Years of Mycopathologia: A Retrospective Analysis of Progress Made in Understanding Human and Animal Fungal Pathogens

Vishnu Chaturvedi, Jean-Philippe Bouchara, Ferry Hagen, Ana Alastruey-Izquierdo, more

Mycopathologia > 2018 > 183 > 6 > 859-877

Mycopathologia was founded in 1938 to ‘diffuse the understanding of fungal diseases in man and animals among mycologists.’ This was an important mission considering that pathogenic fungi for humans and animals represent a tiny minority of the estimated 1.5–5 million fungal inhabitants on Earth. These pathogens have diverged from the usual saprotrophic lifestyles of most fungi to colonize and infect...

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Mycobacterium abscessus infection of a cochlear implant insertion site

Jason H. Anderson, Thomas G. Boyce, Nancy L. Wengenack, Colin L.W. Driscoll, more

International Journal of Pediatric Otorhinolaryngology Extra > 2013 > 8 > 4 > 122-124

Infectious complications of cochlear implantation are unusual but can be severe, often requiring implant removal. We report a child who underwent cochlear implant revision and developed a post-operative infection with Mycobacterium abscessus complex. The patient's symptoms were refractory to empiric antibacterial therapy. After more than 2 weeks incubation, M. abscessus complex grew in culture. Resolution...

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Increased Incidence of Cutaneous Nontuberculous Mycobacterial Infection, 1980 to 2009: A Population-Based Study

Ashley B. Wentworth, Lisa A. Drage, Nancy L. Wengenack, John W. Wilson, more

Mayo Clinic Proceedings > 2013 > 88 > 1 > 38-45

To determine the incidence and clinical characteristics of cutaneous nontuberculous mycobacterial (NTM) infection during the past 30 years and whether the predominant species have changed.Using Rochester Epidemiology Project data, we identified Olmsted County, Minnesota, residents with cutaneous NTM infections between January 1, 1980, and December 31, 2009, examining the incidence of infection, patient...

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Detection of (1, 3)-β-d-glucan in bronchoalveolar lavage and serum samples collected from immunocompromised hosts

Elitza S. Theel, Deborah J. Jespersen, Seher Iqbal, Jean E. Bestrom, more

Mycopathologia > 2013 > 175 > 1-2 > 33-41

The incidence of invasive fungal infections (IFI) has increased in recent years, especially among immunocompromised hosts (ICH). In 2003, the Fungitell^® assay received FDA clearance for the presumptive diagnosis of IFI using serum and detects (1-3)-β-d-glucan, which is a major cell wall component of certain fungi (e.g., Candida, Aspergillus, and Pneumocystis). The goal of the current study was to...

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Mycobacterium wolinskyi: a case series and review of the literature

Ella J. Ariza-Heredia, Ala S. Dababneh, Mark P. Wilhelm, Nancy L. Wengenack, more

Diagnostic Microbiology & Infectious Disease > 2011 > 71 > 4 > 421-427

Mycobacterium wolinskyi is an uncommonly encountered rapidly growing mycobacterium. To date, only 12 clinical cases have been reported in the literature. In this report, we describe 5 additional cases of M. wolinskyi infection seen at the Mayo Clinic in Rochester, MN, since 2009. The clinical manifestations were sternal wound infections (n = 2), a surgical site wound infection, a cardiac-device pocket...

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Pneumocystis jirovecii testing by real-time polymerase chain reaction and direct examination among immunocompetent and immunosuppressed patient groups and correlation to disease specificity

John W. Wilson, Andew H. Limper, Thomas E. Grys, Theresa Karre, more

Diagnostic Microbiology & Infectious Disease > 2011 > 69 > 2 > 145-152

We used real-time polymerase chain reaction (PCR) targeting the cdc2 gene and direct fluorescent microscopy examination (DFME) to evaluate the prevalence of Pneumocystis jirovecii among immunocompetent patients without clinical pulmonary infection and immunosuppressed patients evaluated for opportunistic pulmonary infections. Among 102 bronchoalveolar lavage samples collected from immunocompetent...

article

Meningeal Coccidioidomycosis Diagnosed by Real-Time Polymerase Chain Reaction Analysis of Cerebrospinal Fluid

Matthew J. Binnicker, Alina S. Popa, Jelena Catania, Maria Alexov, more

Mycopathologia > 2011 > 171 > 4 > 285-289

We describe two cases of coccidioidal meningitis (CM) diagnosed using real-time polymerase chain reaction (PCR) analysis of cerebrospinal fluid. These cases highlight the promise of PCR as a diagnostic method to assist in the rapid diagnosis of CM.

article

The Utility of Coccidioides Polymerase Chain Reaction Testing in the Clinical Setting

Darko Vucicevic, Janis E. Blair, Matthew J. Binnicker, Ann E. McCullough, more

Mycopathologia > 2010 > 170 > 5 > 345-351

Coccidioidomycosis, the fungal infection caused by dimorphic Coccidioides sp., is typically diagnosed by histopathologic identification of spherules in affected secretions and tissues or by culture. These tests are reliable but time-intensive, delaying diagnosis and treatment. To evaluate a polymerase chain reaction (PCR) test developed to detect Coccidioides sp. in clinical specimens, we conducted...

article

A real-time polymerase chain reaction assay for detection of Pneumocystis from bronchoalveolar lavage fluid

Rodney C. Arcenas, James R. Uhl, Seanne P. Buckwalter, Andrew H. Limper, more

Diagnostic Microbiology & Infectious Disease > 2006 > 54 > 3 > 169-175

Pneumocystis jiroveci is an important cause of pneumonia in immunocompromised individuals. This organism cannot be cultured, and therefore, diagnosis relies on microscopic identification of the organism using stains or antibodies. Although simple, these tests are insensitive and require expertise for accurate interpretation. We developed a real-time polymerase chain reaction (PCR) assay that provides...

article

Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts

Janis E. Blair, Brandon Coakley, Ana C. Santelli, Joseph G. Hentz, more

Mycopathologia > 2006 > 162 > 5 > 317-324

Serologic studies are an important diagnostic tool in the clinical evaluation and follow-up of persons with coccidioidomycosis. Numerous types of serologic tests are available, including immunodiffusion, enzyme immunoassay, and complement fixation. We conducted a retrospective review of the results of 1,797 serologic tests spanning 12 months from the onset of coccidioidomycosis in 298 immunocompetent...

article

Purification and characterization of Mycobacterium tuberculosis KatG, KatG(S315T), and Mycobacterium bovis KatG(R463L)

Nancy L. Wengenack, Brian D. Lane, Preston J. Hill, James R. Uhl, more

Protein Expression and Purification > 2004 > 36 > 2 > 232-243

Isoniazid, a first-line antibiotic used for the treatment of tuberculosis, is a prodrug that requires activation by the Mycobacterium tuberculosis enzyme KatG. The KatG(S315T) mutation causes isoniazid resistance while the KatG(R463L) variation is thought to be a polymorphism. Much of the work to date focused on isoniazid activation by KatG has utilized recombinant enzyme overexpressed in Escherichia...

article

Insights into the Signal Transduction Mechanism of Rm FixL Provided by Carbon Monoxide Recombination Kinetics ^†

Kenton R. Rodgers, Lei Tang, Gudrun S. Lukat-Rodgers, Nancy L. Wengenack

Biochemistry > 2001 > 40 > 43 > 12932 - 12942

article

Evidence for Isoniazid-Dependent Free Radical Generation Catalyzed by Mycobacterium tuberculosi s KatG and the Isoniazid-Resistant Mutant KatG(S315T)

Nancy L. Wengenack, Frank Rusnak

Biochemistry > 2001 > 40 > 30 > 8990 - 8996

article

Carbon Monoxide Adducts of KatG and KatG(S315T) as Probes of the Heme Site and Isoniazid Binding ^†

Gudrun S. Lukat-Rodgers, Nancy L. Wengenack, Frank Rusnak, Kenton R. Rodgers

Biochemistry > 2001 > 40 > 24 > 7149 - 7157

article

Mycobacterium tuberculosisKatG Is a Peroxynitritase

Nancy L. Wengenack, Michael P. Jensen, Frank Rusnak, Michael K. Stern

Biochemical and Biophysical Research Communications > 1999 > 256 > 3 > 485-487

Mycobacterium tuberculosisresides within the highly oxidative environment of the human macrophage and previous reports have indicated that these mycobacteria are susceptible to reactive nitrogen intermediates including peroxynitrite. This work provides evidence that theMycobacterium tuberculosishemoprotein KatG acts as an efficient peroxynitritase exhibiting ak _a _p _p of 1.4 x 10 ...

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