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Background: The Src family of tyrosine kinases is involved in the propagation of intracellular signals from many transmembrane receptors. Each member of the family contains two domains that regulate interactions with other molecules, one of which is the Src homology 3 (SH3) domain. Although structures have previously been determined for SH3 domains, and ideas about peptide-binding modes have been...
Interleukin 2 (IL-2) is one of the major cytokines produced by T lymphocytes in response to antigen. It is a pootent growth and differentiation factor for several cell-types and is structurally related to the four-helix bundle family of cytokines. Mutation of residue Phe42 to Ala abolishes binding to the α chain of the tri-partite IL-2 receptorThe three-dimensional structure of the F42A mutant IL-2...
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