Search results for: Masayuki Hori

Items from 1 to 16 out of 16 results

article

Liver injury and cytopenia after BNT162b2 COVID‐19 vaccination in an adolescent

Yu Kawasaki, Kousaku Matsubara, Masayuki Hori, Kenichi Isome

Pediatrics International > 64 > 1 > n/a - n/a

article

Langerhans cell histiocytosis with molluscum contagiosum: A correlation?

Ken Washio, Shotaro Fujii, Yu Kawasaki, Sadayuki Nagai, more

The Journal of Dermatology > 44 > 6 > e136 - e137

article

A CD57⁺ CTL Degranulation Assay Effectively Identifies Familial Hemophagocytic Lymphohistiocytosis Type 3 Patients

Masayuki Hori, Takahiro Yasumi, Saeko Shimodera, Hirofumi Shibata, more

Journal of Clinical Immunology > 2017 > 37 > 1 > 92-99

Purpose Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) is a genetic disorder that results in immune dysregulation. It requires prompt and accurate diagnosis. A natural killer (NK) cell degranulation assay is often used to screen for FHL3 patients. However, we recently encountered two cases of late-onset FHL3 carrying novel UNC13D missense mutations: in these cases, the degranulation assays...

article

Neurogenic pulmonary edema combined with febrile seizures in early childhood—A report of two cases

Keiji Tasaka, Kousaku Matsubara, Masayuki Hori, Hiroyuki Nigami, more

IDCases > 2016 > 6 > C > 90-93

Neurogenic pulmonary edema (NPE) is a clinical entity that can occur following central nervous system disorders. However, NPE occurs quite rarely in early childhood, and there has only been one report about pediatric NPE associated with febrile seizures. Two cases are reported here. One case involved a 2-year-old girl who presented with febrile seizures, which rapidly progressed to severe NPE. Since...

article

Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis

Takahiro Yasumi, Masayuki Hori, Eitaro Hiejima, Hirofumi Shibata, more

British Journal of Haematology > 170 > 4 > 532 - 538

Haemophagocytic lymphohistiocytosis (HLH) is a life‐threatening syndrome of immune dysregulation and is classified as primary or secondary according to the underlying aetiology. The treatment strategies recommended for these two groups differ substantially; however, it is thought to be impossible to predict the underlying causes of HLH using conventional laboratory tests. Recent studies show that...

article

Munc13‐4 deficiency with CD5 downregulation on activated CD8⁺ T cells

Taizo Wada, Takahiro Yasumi, Tomoko Toma, Masayuki Hori, more

Pediatrics International > 56 > 4 > 605 - 608

Familial hemophagocytic lymphohistiocytosis (FHL) is characterized by uncontrolled activation of T cells and macrophages and hypercytokinemia. We have recently described a significant increase in a subpopulation of CD8⁺ T cells with downregulation of CD5 during the acute phase of FHL type2 (FHL2; perforin deficiency), which declines after successful treatment, with a concomitant reduction in serum...

article

Effect of combined humanPTH(1–34) and calcitonin treatment in ovariectomized rats

Yuki Washimi, Masato Ito, Yosuke Morishima, Kanako Taguma, more

Bone > 2007 > 41 > 5 > 786-793

We examined the combined effects of human parathyroid hormone 1–34 (hPTH) and elcatonin (ECT: a synthetic derivative of eel calcitonin) to prevent loss of bone mass, architecture and strength in ovariectomized (OVX) rats.Fifty-four female rats (aged 13 weeks) were assigned to one of nine groups: Sham (fake surgery performed), OVX, ECT (15 U/kg administered), PTH5, PTH10 and PTH20 (5, 10 or 20 μg/kg...

article

Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures

Katsuji Haneda, Midori Takeuchi, Mizuka Tagashira, Toshiyuki Inazu, more

Carbohydrate Research > 2006 > 341 > 2 > 181-190

Naturally occurring glycopeptides and glycoproteins usually contain more than one glycosylation site, and the structure of the carbohydrate attached is often different from site to site. Therefore, synthetic methods for preparing peptides and proteins that are glycosylated at multiple sites, possibly with different carbohydrate structures, are needed. Here, we report a chemo-enzymatic approach for...

article

Effects of combined elcatonin and alendronate treatment on the architecture and strength of bone in ovariectomized rats

Koko Ogawa, Masayuki Hori, Ryoko Takao, Toyozo Sakurada

Journal of Bone and Mineral Metabolism > 2005 > 23 > 5 > 351-358

We examined the combined effects of elcatonin (ECT) and alendronate (ALN) on bone mass, architecture, and strength in ovariectomized (OVX) rats. Fifty female Sprague Dawley rats, aged 13 weeks, were divided into Sham, OVX, OVX+ECT, OVX+ALN, and OVX+ECT+ALN groups (n = 10). Immediately after ovariectomy, ECT was administered at a dose of 15 units (U)/kg three times a week, and ALN was administered...

article

Administration of estrogen shortly after ovariectomy mimics the anti-nociceptive action and change in 5-HT ₁ _A -like receptor expression induced by calcitonin in ovariectomized rats

Akitoshi Ito, Mineko Takeda, Hidemasa Furue, Kensuke Shibata, more

Bone > 2004 > 35 > 3 > 697-703

Although many clinical reviews are consistent with the view that hormone replacement therapy should be recommended for increasing bone mass of osteoporotic patients, calcitonin administration is preferable to hormone replacement therapy for the alleviation of pain accompanying osteoporosis, despite the fact that osteoporosis and the accompanying pain are accelerated by the reduction in estrogen levels...

article

Chemo-enzymatic synthesis and structure-activity study of artificially N-glycosylated eel calcitonin derivatives with a complex type oligosaccharide

Katsuji Haneda, Mizuka Tagashira, Eiichi Yoshino, Midori Takeuchi, more

Glycoconjugate Journal > 2004 > 21 > 6 > 377-386

Starting from N-glycosylated eel calcitonin derivatives that contain an N-acetyl-D-glucosamine residue specifically at the 3rd, 14th, 20th or 26th amino acid residue, corresponding glycopeptides with a complex-type oligosaccharide attached to the respective amino acid residue were synthesized by means of a transglycosylation reaction catalyzed by an endo-β-N-acetylglucosaminidase from Mucor hiemalis...

article

Site-Dependent Effect of O-Glycosylation on the Conformation and Biological Activity of Calcitonin ^†

Mizuka Tagashira, Hideki Iijima, Yukihiro Isogai, Masayuki Hori, more

Biochemistry > 2001 > 40 > 37 > 11090 - 11095

article

Effect of carbohydrate structure on biological activity of artificially N-glycosylated eel calcitonin

Mizuka Tagashira, Atsushi Tanaka, Kunio Hisatani, Yukihiro Isogai, more

Glycoconjugate Journal > 2001 > 18 > 6 > 449-455

To reveal the function of the carbohydrate portion of glycopeptides and glycoproteins, we chemo-enzymatically synthesized artificially N-glycosylated derivatives of eel calcitonin and studied their three-dimensional structure and biological activity. The CD and NMR spectra in trifluoroethanol-H₂O solution showed that the glycosylation did not change the three-dimensional structure. All the derivatives...

article

Human parathyroid hormone (1-34) increases urinary excretion of lysosomal enzymes in rats

Takanori Iwata, Shunya Uchida, Masayuki Hori, Kentaro Sakai, more

Life Sciences > 1999 > 65 > 17 > 1725-1732

The kidney is the major target of parathyroid hormone (PTH), and PTH influences the urinary excretion of calcium, phosphate and hydrogen ions. It was previously reported that the urinary excretion of N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme, transiently increases after human PTH (hPTH) (1-34) infusion in normal subjects and idiopathic hypoparathyroidism patients, but not in pseudohypoparathyroidism...

article

Effects of human PTH(1-34) and bisphosphonate on the osteopenic rat model

Tatsuhiko Tanizawa, Noriaki Yamamoto, Yuichi Takano, Tasuku Mashiba, more

Toxicology Letters > 1998 > 102-103 > Complete > 399-403

It has been demonstrated that the intermittent administration of human parathyroid hormone (hPTH) is beneficial for restoration of bone mass in osteoporotic patients. The mechanisms of anabolic effects of hPTH have been determined by ovariectomized rat models and other larger remodeling animals. However, treatment with hPTH may increase the cancellous bone mass at the expense of cortical bone mass...

article

Low dose of human PTH(1-34) improved tibial subcortical bone mass without further cortical bone loss in adult intact beagles

Liu Zhang, Hideaki E. Takahashi, Tatsuhiko Tanizawa, Naoto Endo, more

Journal of Bone and Mineral Metabolism > 1998 > 16 > 2 > 96-99

Abstract: Cortical bone loss has not been observed in parathyroid hormone- (PTH-) treated rats, but clinical investigators suggest that it may augment cancellous bone mass at the expense of cortical bone in PTH-treated patients. In this study, the effects of PTH on cancellous and cortical bone mineral density of the tibia were studied in dogs with Haversian cortical bone remodeling by peripheral quantitative...

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