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GDP-mannose glycosyl hydrolase (GDPMH) catalyzes the hydrolysis of GDP-mannose and GDP-glucose to GDP and sugar by substitution with inversion at C1 of the sugar. The enzyme has a modified Nudix motif and requires one divalent cation for activity. The 1.3 Å X-ray structure of the GDPMH-Mg 2+ -GDP complex, together with kinetic, mutational, and NMR data, suggests a mechanism for the GDPMH reaction...
Mutations in PMR1, a yeast gene encoding a calcium/manganese exporter, dramatically decrease Ty1 retrotransposition. Ty1 cDNA is reduced in pmr1 mutant cells, despite normal levels of Ty1 RNA and proteins. The transposition defect results from Mn 2+ accumulation that inhibits reverse transcription. Cytoplasmic accumulation of Mn 2+ in pmr1 cells may directly affect reverse...
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