Search results for: Ronald N. McElhaney

Items from 1 to 20 out of 74 results

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A calorimetric and spectroscopic comparison of the effects of cholesterol and its sulfur-containing analogs thiocholesterol and cholesterol sulfate on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

Matthew G.K. Benesch, Ruthven N.A.H. Lewis, Ronald N. McElhaney

BBA - Biomembranes > 2016 > 1858 > 2 > 168-180

We performed differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectroscopic studies of the effects of cholesterol (Chol), thiocholesterol (tChol) and cholesterol sulfate (CholS) on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine (DPPC) bilayer membranes. Our DSC results indicate that Chol and tChol incorporation produce small temperature...

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A comparative differential scanning calorimetry study of the effects of cholesterol and various oxysterols on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes

Matthew G.K. Benesch, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2016 > 195 > C > 21-33

We have carried out a comparative differential scanning calorimetric (DSC) study of the effects of cholesterol (C) and the eight most physiologically relevant oxysterols on the thermotropic phase behavior of dipalmitoylphosphatidylcholine (DPPC) bilayer membranes. The structures of these oxysterols differ from that of C by the presence of additional hydroxyl, keto or epoxy groups on the steroid ring...

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On the miscibility of cardiolipin with 1,2-diacyl phosphoglycerides: Binary mixtures of dimyristoylphosphatidylglycerol and tetramyristoylcardiolipin

Matthew G.K. Benesch, Ruthven N.A.H. Lewis, Ronald N. McElhaney

Biochimica et Biophysica Acta (BBA) - Biomembranes > 2015 > 1848 > 11(PA) > 2878-2888

The thermotropic phase behavior and organization of model membranes composed of binary mixtures of the quadruple-chained, nominally dianionic phospholipid tetramyristoylcardiolipin (TMCL) with the double-chained, monoanionic phospholipid dimyristoylphosphatidylglycerol (DMPG) were examined by differential scanning calorimetry (DSC) and Fourier-transform infrared (FTIR) spectroscopy. The gel/liquid-crystalline...

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A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

Matthew G.K. Benesch, Ruthven N.A.H. Lewis, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2015 > 191 > Complete > 123-135

We performed differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectroscopic studies of the effects of cholesterol (CHOL), 7-dehydrocholeterol (7DHC) and desmosterol (DES) on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine (DPPC) bilayer membranes. 7DHC and DES are the immediate biosynthetic precursors of CHOL in the Kandutch–Russell...

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A comparative calorimetric and spectroscopic study of the effects of cholesterol and of the plant sterols β-sitosterol and stigmasterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

David A. Mannock, Matthew G.K. Benesch, Ruthven N.A.H. Lewis, Ronald N. McElhaney

Biochimica et Biophysica Acta (BBA) - Biomembranes > 2015 > 1848 > 8 > 1629-1638

We performed comparative DSC and FTIR spectroscopic measurements of the effects of β-sitosterol (Sito) and stigmasterol (Stig) on the thermotropic phase behavior and organization of DPPC bilayers. Sito and Stig are the major sterols in the biological membranes of higher plants, whereas cholesterol (Chol) is the major sterol in mammalian membranes. Sito differs in structure from Chol in having an ethyl...

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A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues

Matthew G.K. Benesch, Ruthven N.A.H. Lewis, David A. Mannock, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2015 > 188 > Complete > 10-26

We present the results of a comparative differential calorimetric and Fourier transform infrared spectroscopic study of the effect of cholesterol and five analogues on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes. These sterols/steroids differ in both the nature and stereochemistry of the polar head group at C3 (β-OH, α-OH or CO) and in the...

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A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs

Matthew G.K. Benesch, Ruthven N.A.H. Lewis, David A. Mannock, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2015 > 187 > Complete > 34-49

We present the results of a comparative differential calorimetric and Fourier transform infrared spectroscopic study of the effect of cholesterol and five analogs on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. These sterols/steroids differ in both the nature and stereochemistry of the polar head group at C3 (β-OH, α-OH or CO) and in the presence...

article

A DSC and FTIR spectroscopic study of the effects of the epimeric 4,6-cholestadien-3-ols and 4,6-cholestadien-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes

Matthew G.K. Benesch, Ruthven N.A.H. Lewis, David A. Mannock, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2014 > 183 > Complete > 142-158

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A comparative calorimetric study of the effects of cholesterol and the plant sterols campesterol and brassicasterol on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes

Matthew G.K. Benesch, Ronald N. McElhaney

BBA - Biomembranes > 2014 > 1838 > 7 > 1941-1949

We present a comparative differential scanning calorimetric study of the effects of the animal sterol cholesterol (Chol) and the plant sterols campesterol (Camp) and brassicasterol (Bras) on the thermotropic phase behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers. Camp and Bras differ from Chol in having a C24 methyl group and, additionally for Bras, a C22 trans-double bond. Camp and especially...

article

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes

Thomas Abraham, Elmar J. Prenner, Ruthven N.A.H. Lewis, Colin T. Mant, more

Biochimica et Biophysica Acta (BBA) - Biomembranes > 2014 > 1838 > 5 > 1420-1429

GS10 [cyclo-(VKLdYPVKLdYP)] is a synthetic analog of the naturally occurring antimicrobial peptide gramicidin (GS) in which the two positively charged ornithine (Orn) residues are replaced by two positively charged lysine (Lys) residues and the two less polar aromatic phenylalanine (Phe) residues are replaced by the more polar tyrosine (Tyr) residues. In this study, we examine the effects of these...

article

A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues

Matthew G.K. Benesch, David A. Mannock, Ruthven N.A.H. Lewis, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2014 > 177 > Complete > 71-90

We present the results of a comparative differential calorimetric and Fourier transform infrared spectroscopic study of the effect of cholesterol and five of its analogues on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes. These sterols/steroids differ in both the nature and stereochemistry of the polar head group at C3 (βOH, αOH or CO) and in...

article

Membrane lipid phase transitions and phase organization studied by Fourier transform infrared spectroscopy

Ruthven N.A.H. Lewis, Ronald N. McElhaney

BBA - Biomembranes > 2013 > 1828 > 10 > 2347-2358

Fourier transform infrared (FTIR) spectroscopy is a powerful yet relatively inexpensive and convenient technique for studying the structure and organization of membrane lipids in their various polymorphic phases. This spectroscopic technique yields information about the conformation and dynamics of all regions of the lipid molecule simultaneously without the necessity of introducing extrinsic probes...

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A Calorimetric and Spectroscopic Comparison of the Effects of Lathosterol and Cholesterol on the Thermotropic Phase Behavior and Organization of Dipalmitoylphosphatidylcholine Bilayer Membranes

Matthew G. K. Benesch, David A. Mannock, Ruthven N. A. H. Lewis, Ronald N. McElhaney

Biochemistry > 2011 > 50 > 46 > 9982 - 9997

article

On the miscibility of cardiolipin with 1,2-diacyl phosphoglycerides: Binary mixtures of dimyristoylphosphatidylethanolamine and tetramyristoylcardiolipin

Maria Frias, Matthew G.K. Benesch, Ruthven N.A.H. Lewis, Ronald N. McElhaney

BBA - Biomembranes > 2011 > 1808 > 3 > 774-783

The thermotropic phase behavior and organization of model membranes composed of binary mixtures of the quadruple-chained, anionic phospholipid tetramyristoylcardiolipin (TMCL) with the double-chained zwitterionic phospholipid dimyristoylphosphatidylethanolamine (DMPE) were examined by a combination of differential scanning calorimetry (DSC) and Fourier-transform infrared (FTIR) spectroscopy. After...

article

Sterol chemical configuration influences the thermotropic phase behaviour of dipalmitoylphosphatidylcholine bilayers containing 5α-cholestan-3β- and 3α-ol

Matthew G.K. Benesch, David A. Mannock, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2011 > 164 > 1 > 62-69

It is commonly believed that all membrane sterols are rigid all-trans ring systems with a fully extended alkyl side-chain and that they similarly influence phospholipid bilayer physical properties. Here, we report the sterol concentration-dependent, thermotropic phase behaviour of binary dipalmitoylphosphatidylcholine (DPPC)/sterol mixtures containing two similar 5α-H sterols with different functional...

article

Sterol chemical configuration and conformation influence the thermotropic phase behaviour of dipalmitoylphosphatidylcholine mixtures containing 5β-cholestan-3β- and -3α-ol

Matthew G.K. Benesch, David A. Mannock, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2011 > 164 > 1 > 70-77

We report here our differential scanning calorimetry measurements investigating the thermotropic phase behaviour of binary dipalmitoylphosphatidylcholine (DPPC)/sterol mixtures containing two saturated sterols with different ring configurations (5β-H and either 3α-OH or 3β-OH). These measurements differ in the proportions of sharp and broad components in the heating endotherms, representing the melting...

article

The effect of variations in phospholipid and sterol structure on the nature of lipid–sterol interactions in lipid bilayer model membranes

David A. Mannock, Ruthven N.A.H. Lewis, Todd P.W. McMullen, Ronald N. McElhaney

Chemistry and Physics of Lipids > 2010 > 163 > 6 > 403-448

This review deals with the effect of variations in phospholipid and sterol structure on the nature and magnitude of lipid-sterol interactions in lipid bilayer model membranes. The first portion of the review covers the effect of Chol itself on the thermotropic phase behavior and organization of a variety of different glycero- and sphingolipid membrane lipid classes, varying in the structure and charge...

article

A calorimetric and spectroscopic comparison of the effects of ergosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

David A. Mannock, Ruthven N.A.H. Lewis, Ronald N. McElhaney

BBA - Biomembranes > 2010 > 1798 > 3 > 376-388

We performed comparative DSC and FTIR spectroscopic measurements of the effects of cholesterol (Chol) and ergosterol (Erg) on the thermotropic phase behavior and organization of DPPC bilayers. Ergosterol is the major sterol in the biological membranes of yeasts, fungi and many protozoa. It differs from Chol in having two additional double bonds, one in the steroid nucleus at C7–8 and another in the...

article

On the Miscibility of Cardiolipin with the Major Lipid Components of the Bacterial Inner Membrane

Maria Frias, Matthew G.K. Benesch, Ruthven N.A.H. Lewis, Ronald N. McElhaney

Biophysical Journal > 2010 > 98 > 3 Supplement 1 > 272a

article

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

Ruthven N.A.H. Lewis, Ronald N. McElhaney

BBA - Biomembranes > 2009 > 1788 > 10 > 2069-2079

In this review article, we summarize the current state of biophysical knowledge concerning the phase behavior and organization of cardiolipin (CL) and CL-containing phospholipid bilayer model membranes. We first briefly consider the occurrence and distribution of CL in biological membranes and its probable biological functions therein. We next consider the unique chemical structure of the CL molecule...

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Search results for: Ronald N. McElhaney

A calorimetric and spectroscopic comparison of the effects of cholesterol and its sulfur-containing analogs thiocholesterol and cholesterol sulfate on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

A comparative differential scanning calorimetry study of the effects of cholesterol and various oxysterols on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes

On the miscibility of cardiolipin with 1,2-diacyl phosphoglycerides: Binary mixtures of dimyristoylphosphatidylglycerol and tetramyristoylcardiolipin

A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

A comparative calorimetric and spectroscopic study of the effects of cholesterol and of the plant sterols β-sitosterol and stigmasterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues

A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs

A DSC and FTIR spectroscopic study of the effects of the epimeric 4,6-cholestadien-3-ols and 4,6-cholestadien-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes

A comparative calorimetric study of the effects of cholesterol and the plant sterols campesterol and brassicasterol on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes

A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues

Membrane lipid phase transitions and phase organization studied by Fourier transform infrared spectroscopy

A Calorimetric and Spectroscopic Comparison of the Effects of Lathosterol and Cholesterol on the Thermotropic Phase Behavior and Organization of Dipalmitoylphosphatidylcholine Bilayer Membranes

On the miscibility of cardiolipin with 1,2-diacyl phosphoglycerides: Binary mixtures of dimyristoylphosphatidylethanolamine and tetramyristoylcardiolipin

Sterol chemical configuration influences the thermotropic phase behaviour of dipalmitoylphosphatidylcholine bilayers containing 5α-cholestan-3β- and 3α-ol

Sterol chemical configuration and conformation influence the thermotropic phase behaviour of dipalmitoylphosphatidylcholine mixtures containing 5β-cholestan-3β- and -3α-ol

The effect of variations in phospholipid and sterol structure on the nature of lipid–sterol interactions in lipid bilayer model membranes

A calorimetric and spectroscopic comparison of the effects of ergosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes

On the Miscibility of Cardiolipin with the Major Lipid Components of the Bacterial Inner Membrane

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

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