Search results for: Ralph Snyderman

Items from 1 to 7 out of 7 results

article

Patient engagement as a risk factor in personalized health care: a systematic review of the literature on chronic disease

Leigh Ann Simmons, Ruth Q Wolever, Elizabeth M Bechard, Ralph Snyderman

Genome Medicine > 2014 > 6 > 2 > 1-13

Background The role of patient engagement as an important risk factor for healthcare outcomes has not been well established. The objective of this article was to systematically review the relationship between patient engagement and health outcomes in chronic disease to determine whether patient engagement should be quantified as an important risk factor in health risk appraisals to enhance the...

article

Phospholipase C-β2 interacts with mitogen-activated protein kinase kinase 3

Alastair J. Barr, Robin Marjoram, Jing Xu, Ralph Snyderman

Biochemical and Biophysical Research Communications > 2002 > 293 > 1 > 647-652

Phospholipase C (PLC)-β enzymes (isoenzymes β1-β4) are activated by G protein subunits, leading to the generation of intracellular messengers which mobilize calcium and activate protein kinase C. It has recently been recognized that these enzymes interact with and are regulated by proteins other than G proteins. Using the yeast two-hybrid technique to screen a leukocyte library we identified mitogen-activated...

article

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses ^†

Ricardo M. Richardson, Robin J. Marjoram, Alastair J. Barr, Ralph Snyderman

Biochemistry > 2001 > 40 > 12 > 3583 - 3588

article

Function and regulation of chemoattractant receptors

Bodduluri Haribabu, Ricardo M. Richardson, Margrith W. Verghese, Alastair J. Barr, more

Immunologic Research > 2000 > 22 > 2-3 > 271-279

Phagocyte migration and activation at sites of inflammation is mediated through chemoattractant receptors that are coupled to G-proteins. Early studies from our laboratory demonstrated G-protein-mediated phospholipase C activation by chemoattractants. Recently, this laboratory developed cellular and animal models to allow biochemical, cell biological and molecular genetic approaches to be used in...

article

Functional high efficiency expression of cloned leucocyte chemoattractant receptor cDNAs

Jolin R. Didsbury, Ronald J. Uhing, Eric Tomhave, Craig Gerard, more

FEBS Letters > 1992 > 297 > 3 > 275-279

Human kidney 293 TSA cells were transfected by a calcium phosphate method with human formylpeptide and C5a receptor cDNAs with high efficiency. Formylpeptide receptor positive transfectants expressed a total of 968,000 +/- 34,000 receptors per cell with two affinity states (K _d s of ca. 0.43 nM and 39 nM), which in the presence of 100μM GTPγS decreased by ca. 4-fold the number of high-affinity...

article

Molecular cloning of a new human G protein Evidence for two G _i _α -like protein families

John R. Didsbury, Ralph Snyderman

FEBS Letters > 1987 > 219 > 1 > 259-263

The amino acid sequence of a novel G protein α subunit (G _x _α ) has been deduced from the nucleotide sequence of a human cDNA clone isolated from a differentiated HL-60 cDNA library. The cDNA encodes a polypeptide of 354 amino acids (M _r 40 519) which is closely related to G _i _α proteins. The amino acid sequence homology between G _x _α and human myeloid G...

article

Human G _i protein α-subunit: deduction of amino acid structure from a cloned cDNA

John R. Didsbury, Ye-Shih Ho, Ralph Snyderman

FEBS Letters > 1987 > 211 > 2 > 160-164

The amino acid sequence of the α-subunit of G _i , the human adenylate cyclase inhibiting GTP-binding protein, has been deduced from the nucleotide sequence of a DNA clone complementary to G _i _α , mRNA from differentiated U937 cells. The cDNA encodes a polypeptide of 355 amino acids (M _r 40456). The amino acid sequence homology between human G _i _α and rat, murine,...

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Search results for: Ralph Snyderman

Patient engagement as a risk factor in personalized health care: a systematic review of the literature on chronic disease

Phospholipase C-β2 interacts with mitogen-activated protein kinase kinase 3

RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses †

Function and regulation of chemoattractant receptors

Functional high efficiency expression of cloned leucocyte chemoattractant receptor cDNAs

Molecular cloning of a new human G protein Evidence for two G i α -like protein families

Human G i protein α-subunit: deduction of amino acid structure from a cloned cDNA

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RGS4 Inhibits Platelet-Activating Factor Receptor Phosphorylation and Cellular Responses ^†

Molecular cloning of a new human G protein Evidence for two G _i _α -like protein families

Human G _i protein α-subunit: deduction of amino acid structure from a cloned cDNA