Douglas A. Steeber

article

Enzymeless Glucose Detection Based on CoO/Graphene Microsphere Hybrids

Suqin Ci, Shun Mao, Taizhong Huang, Zhenhai Wen, more

An ultrasonic nebulizer‐based spray method was developed to fabricate microshpere hybrids of crumpled graphene (CG) loading cobalt oxide (CoO). The as‐prepared CoO/CG microsphere hybrids were used for constructing an enzymeless sensor for glucose detection in alkaline solution. The as‐developed enzymeless glucose sensor exhibited rapid response (less than 3 s), high sensitivity (669.78 µA mM⁻¹ cm⁻²...

article

Single-walled carbon nanotube field-effect transistors with graphene oxide passivation for fast, sensitive, and selective proteindetection

Jingbo Chang, Shun Mao, Yang Zhang, Shumao Cui, more

Biosensors and Bioelectronics > 2013 > 42 > Complete > 186-192

We report a novel technique to design an insulating membrane with attachment sites on top of single-walled carbon nanotubes (SWNTs) for achieving high sensitivity and selectivity in an SWNT field-effect transistor (FET) biosensor. Because electronic properties of SWNTs are extremely sensitive to the surface state, direct immobilization of proteins or DNAs onto SWNTs will generate surface defects through...

article

cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

Xiaoqiang Yang, Hao Hong, Jamison J. Grailer, Ian J. Rowland, more

Biomaterials > 2011 > 32 > 17 > 4151-4160

Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were developed for targeted drug delivery and positron emission tomography/magnetic resonance imaging (PET/MRI) dual-modality imaging of tumors with integrin α _v β ₃ expression. An anticancer drug was conjugated onto the PEGylated SPIO nanocarriers via pH-sensitive bonds. Tumor-targeting ligands, cyclo(Arg-Gly-Asp-d-Phe-Cys)...

article

α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin

Hanako Ohmatsu, Takafumi Kadono, Makoto Sugaya, Manabu Tomita, more

The Journal of Allergy and Clinical Immunology > 2010 > 126 > 6 > 1267-1276

β7 Integrin, a cell adhesion molecule, is present in the form of α4β7 integrin or αEβ7 integrin. α4β7 Integrin is expressed on most leucocytes and is essential for their migration to gut-associated lymphoid tissues by interacting with its primary ligand, mucosal addressin cell adhesion molecule-1, which is preferentially expressed in gut-associated lymphoid tissues. Although the importance of α4β7...

article

Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging

Xiaoqiang Yang, Jamison J. Grailer, Ian J. Rowland, Alireza Javadi, more

Biomaterials > 2010 > 31 > 34 > 9065-9073

Stable and tumor-targeting multifunctional wormlike polymer vesicles simultaneously loaded with superparamagnetic iron oxide (SPIO) nanoparticles (NPs) as magnetic resonance imaging (MRI) contrast agent and anticancer drug doxorubicin (DOX) were developed for targeted cancer therapy and ultrasensitive MR imaging. These multifunctional wormlike polymer vesicles were formed by heterobifunctional amphiphilic...

article

Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging

Xiaoqiang Yang, Jamison J. Grailer, Ian J. Rowland, Alireza Javadi, more

ACS Nano > 2010 > 4 > 11 > 6805 - 6817

article

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Bioconjugate Chemistry > 2010 > 21 > 3 > 496 - 504

article

L-selectin: Role in regulating homeostasis and cutaneous inflammation

Jamison J. Grailer, Masanari Kodera, Douglas A. Steeber

Journal of Dermatological Science > 2009 > 56 > 3 > 141-147

The maintenance of immune surveillance and the generation of normal immune responses are dependent on leukocyte migration to appropriate lymphoid and non-lymphoid tissues. The process of leukocyte migration occurs through complex and highly regulated interactions between the circulating leukocytes and the vascular endothelium. Multiple families of adhesion molecules as well as specific chemoattractants...

article

Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds

Ashutosh Tiwari, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Acta Biomaterialia > 2009 > 5 > 9 > 3441-3452

Guar gum (GG) is a non-ionic polysaccharide that is found abundantly in nature and has many properties desirable for biomedical applications. In the present work GG with molecular weights ranging from 74 to 210kDa was modified with glycidyl methacrylate (GMA) to produce a series of water-soluble photopolymerizable guar gum–methacrylate (GG–MA) macromonomers of different molecular weights. We investigated...

article

Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery

Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Biomaterials > 2009 > 30 > 29 > 5757-5766

Folate-conjugated unimolecular micelles based on amphiphilic hyperbranched block copolymer, Boltorn ^® H40-poly(l-aspartate-doxorubicin)-b-poly(ethylene glycol)/FA-conjugated poly(ethylene glycol) (H40-P(LA-DOX)-b-PEG-OH/FA), were synthesized as a carrier for tumor-targeted drug delivery. The anticancer drug DOX was covalently conjugated onto the hydrophobic segments of the amphiphilic block...

article

Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery

Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Biomaterials > 2009 > 30 > 30 > 6065-6075

Gold (Au) nanoparticles (NPs) stabilized with a monolayer of folate-conjugated poly(l-aspartate-doxorubicin)-b-poly(ethylene glycol) copolymer (Au-P(LA-DOX)-b-PEG-OH/FA) was synthesized as a tumor-targeted drug delivery carrier. The Au-P(LA-DOX)-b-PEG-OH/FA NPs consist of an Au core, a hydrophobic poly(l-aspartate-doxorubicin) (P(LA-DOX)) inner shell, and a hydrophilic poly(ethylene glycol) and folate-conjugated...

article

Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery

Mani Prabaharan, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, more

Biomaterials > 2009 > 30 > 16 > 3009-3019

Folate-conjugated amphiphilic hyperbranched block copolymer (H40–PLA-b-MPEG/PEG–FA) with a dendritic Boltorn ^® H40 core, a hydrophobic poly(l-lactide) (PLA) inner shell and a hydrophilic methoxy poly(ethylene glycol) (MPEG) and folate-conjugated poly(ethylene glycol) (PEG–FA) outer shell was synthesized as a carrier for tumor-targeted drug delivery. The block copolymer was characterized using...

chapter

Fabrication and characterization of microwave immunosensors based on organic semiconductors with nanogold-labeled antibody

Feng Li, David P. Klemer, John K. Kimani, Shun Mao, more

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society > 2381 - 2384

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Microelectronic biosensors hold great promise for rapid, sensitive and specific in vitro point-of-care immunodiagnostics. In particular, sensors fabricated using organic semiconductors have attractive advantages—such as ease of manufacture and low cost—in the design and implementation of such devices. Furthermore, immobilization of an antibody or protein antigen as a biorecognition element onto an...

article

E- and P-Selectins Synergistically Inhibit Bleomycin-Induced Pulmonary Fibrosis

Mayuka Horikawa, Manabu Fujimoto, Minoru Hasegawa, Takashi Matsushita, more

The American Journal of Pathology > 2006 > 169 > 3 > 740-749

The development of bleomycin-induced lung injury, which is a model of pulmonary fibrosis, results from inflammatory cell infiltration, a process highly regulated by the expression of multiple adhesion molecules. Therefore, bleomycin-induced lung fibrosis was examined in E-selectin ^−/− mice, P-selectin ^−/− mice, and E-selectin ^−/− mice treated with anti-P-selectin monoclonal...

article

B-1a and B-1b Cells Exhibit Distinct Developmental Requirements and Have Unique Functional Roles in Innate and Adaptive Immunity to S. pneumoniae

Karen M. Haas, Jonathan C. Poe, Douglas A. Steeber, Thomas F. Tedder

Immunity > 2005 > 23 > 1 > 7-18

B-1a and B-1b lymphocytes were found to exhibit specialized roles in providing immunity to Streptococcus pneumoniae and differ dramatically in their developmental requirements. Transgenic mice overexpressing CD19 (hCD19Tg) generated B-1a cells and natural antibodies that provided protection during infection, while CD19-deficient (CD19 ^−/− ) mice lacked B-1a cells, lacked natural antibodies,...

article

A new twist to the leukocyte adhesion cascade: intimate cooperation is key

Douglas A. Steeber, Guglielmo M. Venturi, Thomas F. Tedder

Trends in Immunology > 2005 > 26 > 1 > 9-12

Leukocyte migration from blood into lymphoid and non-lymphoid tissues requires a highly orchestrated series of adhesive and signaling events. A network of adhesion molecules with overlapping functions mediate the capture, rolling and firm adhesion of leukocytes to the vascular endothelium. A new study adds a novel twist to this paradigm by demonstrating that two adhesion molecules, CD44 and VLA-4,...

article

Leukocyte Migration Is Regulated by L-Selectin Endoproteolytic Release

Guglielmo M. Venturi, LiLi Tu, Takafumi Kadono, Adil I. Khan, more

Immunity > 2003 > 19 > 5 > 713-724

L-selectin mediates lymphocyte migration to peripheral lymph nodes and leukocyte rolling on vascular endothelium during inflammation. One unique feature that distinguishes L-selectin from other adhesion molecules is that it is rapidly cleaved from the cell surface after cellular activation. The biological significance of L-selectin endoproteolytic release was determined by generating gene-targeted...

article

Relative Contributions of Selectins and Intercellular Adhesion Molecule-1 to Tissue Injury Induced by Immune Complex Deposition

Koichi Yanaba, Yuko Kaburagi, Kazuhiko Takehara, Douglas A. Steeber, more

The American Journal of Pathology > 2003 > 162 > 5 > 1463-1473

Immune complex-induced tissue injury is mediated by inflammatory cell infiltration that is highly regulated by multiple adhesion molecules. To assess the relative contribution of adhesion molecules, including selectins and ICAM-1, in this pathogenetic process, the cutaneous passive Arthus reaction was examined in mice lacking E-selectin, P-selectin, or both L-selectin and ICAM-1 with anti-P- or E-selectin...

article

Complement Receptors CD21/35 Link Innate and Protective Immunity during Streptococcus pneumoniae Infection by Regulating IgG3 Antibody Responses

Karen M. Haas, Minoru Hasegawa, Douglas A. Steeber, Jonathan C. Poe, more

Immunity > 2002 > 17 > 6 > 713-723

The CD21/35 receptor provides an important link between innate and adaptive immunity. Its importance during protective immune responses to encapsulated extracellular bacteria was assessed using a new line of mice completely deficient in CD21/35 expression (CD21/35 ^- ^/ ^- ). CD21/35 expression was essential for the rapid trapping of C3dg-antigen complexes by B cells in vivo, especially...

article

Intercellular Adhesion Molecule-1 and L-Selectin Regulate Bleomycin-Induced Lung Fibrosis

Yasuhito Hamaguchi, Yoriko Nishizawa, Masahide Yasui, Minoru Hasegawa, more

The American Journal of Pathology > 2002 > 161 > 5 > 1607-1618

The development of bleomycin-induced lung injury, a model of pulmonary fibrosis, results from inflammatory cell infiltration, a process highly regulated by the expression of multiple adhesion molecules. At present, the identity and role of the adhesion molecules involved in the fibrotic process are unknown. Therefore, bleomycin-induced pulmonary fibrosis was examined in mice lacking L-selectin (L-selectin...

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Search results for: Douglas A. Steeber

Enzymeless Glucose Detection Based on CoO/Graphene Microsphere Hybrids

Single-walled carbon nanotube field-effect transistors with graphene oxide passivation for fast, sensitive, and selective proteindetection

cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin

Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging

Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

L-selectin: Role in regulating homeostasis and cutaneous inflammation

Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds

Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery

Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery

Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(l-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery

Fabrication and characterization of microwave immunosensors based on organic semiconductors with nanogold-labeled antibody

E- and P-Selectins Synergistically Inhibit Bleomycin-Induced Pulmonary Fibrosis

B-1a and B-1b Cells Exhibit Distinct Developmental Requirements and Have Unique Functional Roles in Innate and Adaptive Immunity to S. pneumoniae

A new twist to the leukocyte adhesion cascade: intimate cooperation is key

Leukocyte Migration Is Regulated by L-Selectin Endoproteolytic Release

Relative Contributions of Selectins and Intercellular Adhesion Molecule-1 to Tissue Injury Induced by Immune Complex Deposition

Complement Receptors CD21/35 Link Innate and Protective Immunity during Streptococcus pneumoniae Infection by Regulating IgG3 Antibody Responses

Intercellular Adhesion Molecule-1 and L-Selectin Regulate Bleomycin-Induced Lung Fibrosis

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