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Dendrimers have emerged as topical microbicides to treat vaginal infections. This study explores the in vitro, in vivo antimicrobial activity of PAMAM dendrimers, and the associated mechanism. Interestingly, topical cervical application of 500μg of generation-4 neutral dendrimer (G 4 -PAMAM-OH) showed potential to treat the Escherichia coli induced ascending uterine infection in guinea pig...
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