Search results for: Hisataka Kobayashi

Items from 1 to 20 out of 105 results

article

Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination

Tadanobu Nagaya, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, more

Gastric Cancer > 2019 > 22 > 3 > 463-472

Background Peritoneal dissemination (PD) of abdominal malignancies is a common form of metastasis and its presence signals a poor prognosis. New treatment is required for patients with PD. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody–photo-absorber conjugate (APC). In this study, we investigate in vitro and in vivo efficacy of trastuzumab...

article

581 - Near Infrared Photoimmunotherapy Using Diffuser for Targeting Peritoneal Gastric Cancer Dissemination

Tadanobu Nagaya, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, more

Gastroenterology > 2018 > 154 > 6(S1) > S-120-S-121

article

Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3−/− mice transplanted with human PBMCs

Hiromi Ogata-Aoki, Nobuyo Higashi-Kuwata, Shin-ichiro Hattori, Hironori Hayashi, more

Antiviral Research > 2018 > 149 > C > 78-88

Employing NOD/SCID/Jak3^−/− mice transplanted with human PBMCs (hNOJ mice) and replication-competent, red-fluorescent-protein (mCherry; mC)-labeled HIV-1_JR-FL (HIV_mC), we examined whether early antiretroviral treatment blocked the establishment of HIV-1 infection. The use of hNOJ mice and HIV_mC enabled us to visually locate infection foci and to examine the early dynamics of HIV_mC infection without...

chapter

Eliciting host immunity selectively against cancer cells treated with silica-phthalocyanine-based near infrared photoimmunotherapy

Hisataka Kobayashi

2017 Conference on Lasers and Electro-Optics (CLEO) > 1 - 2

2017 Conference on Lasers and Electro-Optics (CLEO)

Near infrared photoimmunotherapy (NIR-PIT) is a new type of molecularly-targeted cancer photo-therapy based on antibody-photosensitizer conjugates. By crashing cancer or immuno-suppressor cells, NIR-PIT efficiently activates host immunity against NIR-PIT treated cancer cells growing in patients.

article

Real-time monitoring of microdistribution of antibody-photon absorber conjugates during photoimmunotherapy in vivo

Qinggong Tang, Tadanobu Nagaya, Yi Liu, Jonathan Lin, more

Journal of Controlled Release > 2017 > 260 > C > 154-163

Photoimmunotherapy (PIT) is an emerging low side effect cancer therapy based on a monoclonal antibody (mAb) conjugated with a near-infrared (NIR) phthalocyanine dye IRDye 700DX. IR700 is fluorescent, can be used as an imaging agent, and also is phototoxic. It induces rapid cell death after exposure to NIR light. PIT induces highly selective cancer cell death, while leaving most of tumor blood vessels...

article

Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice

Nobuyo Higashi-Kuwata, Hiromi Ogata-Aoki, Shin-ichiro Hattori, Hironori Hayashi, more

Antiviral Research > 2017 > 144 > C > 83-92

We attempted to elucidate early-phase dynamics of HIV-1 infection using replication-competent, red-fluorescent-protein (mCherry)-labeled HIV-1_JR-FL (HIV_JR-FL^mC) and NOD/SCID/Jak3^-/- mice transplanted with Individual-A's human peripheral blood mononuclear cells (hPBMC)(hNOJ mice). On day 7 following HIV_JR-FL^mC inoculation, mCherry-signal-emitting infection foci were readily identified in the subserosa...

article

Noninvasive detection of enzyme activity in tumor models of human ovarian cancer using catalyCEST MRI

Sanhita Sinharay, Edward A. Randtke, Kyle M. Jones, Christine M. Howison, more

Magnetic Resonance in Medicine > 77 > 5 > 2005 - 2014

Purpose We proposed to detect the in vivo enzyme activity of γ‐glutamyl transferase (GGT) within mouse models of human ovarian cancers using catalyCEST MRI with a diamagnetic CEST agent. Methods A CEST‐FISP MRI protocol and a diamagnetic CEST agent were developed to detect GGT enzyme activity in biochemical solution. A quantitative Michaelis‐Menten enzyme kinetics study was performed to confirm...

article

PNFLBA-12 TARGETING EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 EXPRESSING BLADDER CANCER USING COMBINATION PHOTOIMMUNOTHERAPY (PIT)

mohammad siddiqui, Reema Railkar, Thomas Sanford, Peter Choyke, more

The Journal of Urology > 2017 > 197 > 4(S) > e915

article

Surgical tissue handling methods to optimize ex vivo fluorescence with the activatable optical probe γ‐glutamyl hydroxymethyl rhodamine green

Toshiko Harada, Yuko Nakamura, Kazuhide Sato, Tadanobu Nagaya, more

Contrast Media & Molecular Imaging > 11 > 6 > 572 - 578

Optical fluorescence imaging has been developed as an aid to intraoperative diagnosis to improve surgical and endoscopic procedures. Compared with other intraoperative imaging methods, it is lower in cost, has a high safety margin, is portable and easy to use. γ‐glutamyl hydroxymethyl rhodamine green (gGlu‐HMRG) is a recently developed activatable fluorescence probe that emits strong fluorescence...

article

Near infrared photoimmunotherapy of B-cell lymphoma

Tadanobu Nagaya, Yuko Nakamura, Kazuhide Sato, Toshiko Harada, more

Molecular Oncology > 2016 > 10 > 9 > 1404-1414

Near infrared photoimmunotherapy (NIR-PIT) is a new, highly-selective cancer theranostics that employs an antibody-photo absorber conjugate (APC). NIR-PIT has successfully treated preclinical tumor models with APCs and is now in the first-in-human phase 1 clinical trial for head and neck cancer patients against EGFR. CD20 is highly expressed in many B-cell lymphomas and is emerging as a molecular...

article

Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology

Hisataka Kobayashi, Peter L Choyke, Mikako Ogawa

Current Opinion in Chemical Biology > 2016 > 33 > C > 32-38

The monoclonal antibody (mAb) has proven to be a good platform for designing specific molecular imaging probes due to its superior binding specificity. Several optical imaging probes have been developed for surgical navigation in patients and are in early phase clinical trials. However, an inherent limitation of using the mAb is its pharmacokinetics which result in a prolonged circulating half-life...

article

Quantum dot nanoparticle for optimization of breast cancer diagnostics and therapy in a clinical setting

Dina Radenkovic, Hisataka Kobayashi, Ernö Remsey-Semmelweis, Alexander M. Seifalian

Nanomedicine: Nanotechnology, Biology and Medicine > 2016 > 12 > 6 > 1581-1592

Breast cancer is the most common cancer in the world. Sentinel lymph node (SLN) biopsy is used for staging of axillary lymph nodes. Organic dyes and radiocolloid are currently used for SLN mapping, but expose patients to ionizing radiation, are unstable during surgery and cause local tissue damage. Quantum dots (QD) could be used for SLN mapping without the need for biopsy. Surgical resection of the...

article

Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT)

Tadanobu Nagaya, Yuko Nakamura, Kazuhide Sato, Toshiko Harada, more

Journal of Controlled Release > 2016 > 232 > C > 1-8

Near infrared photoimmunotherapy (NIR-PIT), a targeted cancer therapy which uses an antibody-photo absorber conjugate (APC) and near infrared light exposure, dramatically improves nano-drug delivery into treated tumor beds due to enhanced vascular permeability. We investigated the micro-distribution of APCs in a variety of NIR-PIT treated tumors. Either cetuximab (cet) or trastuzumab (tra) conjugated...

chapter

Lymphangiogenesis and Imaging of the Lymphatics in Cancer

Baris Turkbey, Gregory Ravizzini, Peter L. Choyke, Hisataka Kobayashi

Cancer Metastasis — Biology and Treatment > Lymphangiogenesis in Cancer Metastasis > 159-184

Metastatic spread of cancer is one of the major causes of cancer death. The lymphatics contribute to metastatic spread by providing a conduit for the spread of cancer cells. Tumors actively induce new lymphatic formation by deploying growth factors, a process known as lymphangiogenesis. Systemic lymphatic imaging with conventional modalities such as computed tomography, magnetic resonance imaging...

article

Total Synthesis of the Proposed Structure of Turkiyenine

Hisataka Kobayashi, Yusuke Sasano, Naoki Kanoh, Eunsang Kwon, more

European Journal of Organic Chemistry > 2016 > 2 > 270 - 273

The secondary metabolite, turkiyenine, is a probable bioactive component of the medicinal plant, Hypecoum procumbens L. Structurally, it is an isoquinoline‐derived alkaloid composed of dihydrobenzofuran and 3‐benzazepine‐1‐one moieties arranged in a unique spirocyclic structure. Yet despite the intriguing structure and medicinal relevance of benzofuran and benzazepine motifs, neither a synthetic study...

article

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, more

BMC Cancer > 2016 > 16 > 1 > 1-10

Background Photoimmunotherapy (PIT) is a novel type of molecular optical imaging-guided cancer phototherapy based on a monoclonal antibody conjugated to a photosensitizer, IR700, in combination with near-infrared (NIR) light. PIT rapidly causes target-specific cell death by inducing cell membrane damages and appears to be highly effective; however, we have previously demonstrated that tumor recurrences...

article

Near‐IR Light‐Mediated Cleavage of Antibody–Drug Conjugates Using Cyanine Photocages

Roger R. Nani, Alexander P. Gorka, Tadanobu Nagaya, Hisataka Kobayashi, more

Angewandte Chemie > 127 > 46 > 13839 - 13842

Despite significant progress in the clinical application of antibody drug conjugates (ADCs), novel cleavage strategies that provide improved selectivity are still needed. Herein is reported the first approach that uses near‐IR light to cleave a small molecule from a biomacromolecule, and its application to the problem of ADC linkage. The preparation of cyanine antibody conjugates, drug cleavage mediated...

article

Near‐IR Light‐Mediated Cleavage of Antibody–Drug Conjugates Using Cyanine Photocages

Roger R. Nani, Alexander P. Gorka, Tadanobu Nagaya, Hisataka Kobayashi, more

Angewandte Chemie International Edition > 54 > 46 > 13635 - 13638

article

Near infrared photoimmunotherapy for lung metastases

Kazuhide Sato, Tadanobu Nagaya, Makoto Mitsunaga, Peter L. Choyke, more

Cancer Letters > 2015 > 365 > 1 > 112-121

Lung metastases are a leading cause of cancer related deaths; nonetheless current treatments are limited. Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies that target tumors with the toxicity induced by photosensitizers activated by NIR-light. Herein, we demonstrate the efficacy of NIR-PIT in a mouse model of lung...

article

Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models

Ali A. Maawy, Yukihiko Hiroshima, Yong Zhang, Miguel Garcia-Guzman, more

Journal of Surgical Research > 2015 > 197 > 1 > 5-11

Photoimmunotherapy (PIT) is based on the use of a monoclonal antibody specific to cancer epitopes conjugated to a photosensitizer near-infrared phthalocyanine dye (IR700). In this study, PIT with IR700 conjugated to anti-carcinoembryonic antigen (CEA) was used as an adjunct to surgery in orthotopically-implanted human pancreatic cancer in a nude mouse model to eliminate microscopic disease in the...

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INFONA - science communication portal

Search results for: Hisataka Kobayashi

Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination

581 - Near Infrared Photoimmunotherapy Using Diffuser for Targeting Peritoneal Gastric Cancer Dissemination

Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3−/− mice transplanted with human PBMCs

Eliciting host immunity selectively against cancer cells treated with silica-phthalocyanine-based near infrared photoimmunotherapy

Real-time monitoring of microdistribution of antibody-photon absorber conjugates during photoimmunotherapy in vivo

Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice

Noninvasive detection of enzyme activity in tumor models of human ovarian cancer using catalyCEST MRI

PNFLBA-12 TARGETING EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 EXPRESSING BLADDER CANCER USING COMBINATION PHOTOIMMUNOTHERAPY (PIT)

Surgical tissue handling methods to optimize ex vivo fluorescence with the activatable optical probe γ‐glutamyl hydroxymethyl rhodamine green

Near infrared photoimmunotherapy of B-cell lymphoma

Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology

Quantum dot nanoparticle for optimization of breast cancer diagnostics and therapy in a clinical setting

Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT)

Lymphangiogenesis and Imaging of the Lymphatics in Cancer

Total Synthesis of the Proposed Structure of Turkiyenine

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

Near‐IR Light‐Mediated Cleavage of Antibody–Drug Conjugates Using Cyanine Photocages

Near‐IR Light‐Mediated Cleavage of Antibody–Drug Conjugates Using Cyanine Photocages

Near infrared photoimmunotherapy for lung metastases

Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models

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