Search results for: Eun Seong Lee

Items from 1 to 20 out of 138 results

article

Singlet oxygen‐responsive hyaluronate dot clusters for tumor therapy

Hyunji Yoon, Eunsol Lee, Eun Seong Lee

Polymers for Advanced Technologies > 35 > 2 > n/a - n/a

In this study, we developed nanoclusters that respond to singlet oxygen and can be adjusted in size to enhance the efficacy of tumor therapy. Specifically, we engineered nanoclusters, denoted as dHA_c‐PSDA‐Ce6, through the covalent conjugation of hyaluronate dots (dHA) with 3,3‐(propane‐2,2‐diylbis(sulfanediyl))dipropionic acid (PSDA) as a cleavable crosslinker mediated by singlet oxygen, and chlorin...

article

pH‐dependent swellable hyaluronate nanogels targeting acidic tumors

Jeonghun Song, Eunsol Lee, Eun Seong Lee

Polymers for Advanced Technologies > 34 > 11 > 3485 - 3492

In this study, we have developed pH‐dependent nanogels based on hyaluronic acid (HA) to specifically target acidic tumors. Our initial approach involved modifying HA through the grafting of 3‐(diethylamino)propylamine (DEAP), a molecule known for its responsiveness to changes in pH. This modified HA was termed as HDEA. Subsequently, we performed chemical crosslinking of HDEA using adipic acid dihydrazide...

article

Polymyxin B/chlorine e6 conjugated hyaluronate dot particles for antimicrobial photodynamic therapy

Yoonyoung Kim, Kyung Taek Oh, Yu Seok Youn, Eun Seong Lee

Polymers for Advanced Technologies > 34 > 5 > 1557 - 1564

In this study, we report ultrafine‐sized antibiotic dot particles targeting gram‐negative bacteria. The water‐soluble ultrafine‐sized hyaluronate dot (dHA) was conjugated with polymyxin B (PMB, as a target material for lipopolysaccharide on a gram‐negative bacteria) and chlorine e6 (Ce6, as a model photosensitizer), and it was denoted as dHA‐(PMB/Ce6). These dot particles interacted with lipopolysaccharide...

article

Development of biocompatible electrostatic‐repulsive microparticles for local tumor treatment

Eunsol Lee, Eun Seong Lee

Polymers for Advanced Technologies > 33 > 1 > 173 - 179

In this study, we reported pH‐responsive microparticles consisting of poly(D,L‐lactide‐co‐glycolide) (PLGA), aminated hyaluronic acid (aHA) conjugated with 2,3‐dimethylmaleic anhydride (DMA, as a pH‐responsive cleavable molecule) (aHA‐DMA), and doxorubicin (DOX, as an antitumor drug) for local tumor treatment. The DOX‐loaded microparticles, denoted as PLGA(aHA‐DMA)/DOX MPs, were fabricated using the...

article

The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks

Eun Seong Lee, HyunChul Youn, Won Seok William Hyung, Sangil Suh, more

European Journal of Neuroscience > 54 > 7 > 6663 - 6672

Co‐occurring depression and mild cognitive impairment (MCI) in older adults are important because they have a high risk of conversion to dementia. In the present study, task‐related F‐18 fluorodeoxyglucose positron emission tomography (FDG‐PET) was used to analyse older adults with concomitant depression and MCI. We recruited 20 older adults with simultaneous depression and MCI and 10 older adults...

article

Development of pH‐responsive cyclodextrin nanoparticles for tumor‐specific photodynamic therapy

Seonyoung Yoon, Gwang Jin Noh, Yu Seok Youn, Kyung Taek Oh, more

Polymers for Advanced Technologies > 31 > 12 > 3228 - 3237

In this study, we report pH‐responsive porous polysaccharide nanoparticles (NPs) for tumor‐specific photodynamic therapy. Herein, γ‐cyclodextrin (γCD) conjugated with 3‐(diethylamino)propylamine (DEAP, as a pH‐responsive moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD‐(DEAP/PEG) NPs using a self‐assembling process with γCD and PEG as a hydrophilic segment and DEAP as a hydrophobic...

article

Development of Three Driver State Detection Models from Driving Information Using Vehicle Simulator; Normal, Drowsy and Drunk Driving

Kang Hee Lee, Keon Hee Baek, Su Bin Choi, Nak Tak Jeong, more

International Journal of Automotive Technology > 2019 > 20 > 6 > 1205-1219

Detection of drivers' states is the essential technology not only to prevent car accidents related with their state but to develop self-driving car. Detecting technology generally uses two types of methods; physiological measures and vehicle-based measures. Vehicle-based measures have advantages compared to physiological method such as non-additional device, unsophisticated process and less computational...

article

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

Juri Park, Min Jeong Lee, Guk Young Ahn, Tae Hoon Yun, more

Macromolecular Research > 2019 > 27 > 9 > 839-842

This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus,...

article

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

Gwang Jin Noh, Seon A Lim, Eun Seong Lee

Polymers for Advanced Technologies > 30 > 8 > 2067 - 2074

In this study, we report pH‐responsive polysaccharidic nanogels comprising starch grafted with 3‐(diethylamino)propylamine (DEAP, as an inner soft nanogel core) and poly(ethylene glycol) (PEG, as an outer hydrophilic nanogel shell). Here, the DEAP moieties (pK_b ~ pH 7.0) enhance the lipophilicity of the nanogel core at pH 7.4, improving the loading efficiency of an antitumor model drug (docetaxel...

article

A pH-Sensitive Polymer for Cancer Targeting Prepared by One-Step Modulation of Functional Side Groups

Taehoon Sim, Sang Myung Han, Chaemin Lim, Woong Roeck Won, more

Macromolecular Research > 2019 > 27 > 8 > 795-802

Nanocarriers with pH-sensitive functionality are of great interest in the development of pH-dependent drug release compounds in acidic tumor microenvironments. A new polyelectrolyte block copolymer, poly[(benzyl-L-aspartate)-co-(N-(3-aminopropyl) imidazole-L-aspartamide)]-poly(ethylene glycol) (PABI-PEG), was prepared by one-step modulation to produce pH-sensitive nanocarriers. PABI-PEG formed a stable...

article

Loosening mechanism of threaded fastener for complex structures

Keon-Hee Baek, Nak-Tak Jeong, Hee-Rok Hong, Su-bin Choi, more

Journal of Mechanical Science and Technology > 2019 > 33 > 4 > 1689-1702

Threaded fasteners are widely used in mechanical structures primarily owing to their easy disassembly for maintenance and low cost. However, the loosening mechanism of threaded fasteners due to dynamic loading has remained unclear for the past six decades. Current researches on complex structures comprising three or more components are insufficient. The two most common failure modes of threaded fasteners...

article

Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment

HyunChul Youn, Eun Seong Lee, Suji Lee, Sangil Suh, more

Journal of Affective Disorders > 2018 > 239 > C > 30-36

Depression is a risk factor for mild cognitive impairment (MCI) and for the conversion from MCI to Alzheimer's disease (AD). This study investigated regional cerebral glucose metabolism (rCMglc) in older adults with depression and MCI, either with or without amyloidopathy.We recruited 31 older adults diagnosed with depression and MCI, and 21 older adults with normal cognition (NC). All participants...

article

Chlorin e6‐embedded starch nanogels for improved photodynamic tumor ablation

Seon A Lim, Hongsuk Park, Jae Min Lee, Eun Seong Lee

Polymers for Advanced Technologies > 29 > 11 > 2766 - 2773

In this study, we report on a polysaccharide‐based nanogel composed of starch conjugated with a photosensitizing chlorin e6 (Ce6) and hydrophilic poly (ethylene glycol) (PEG). The proposed design of the nanogel takes advantage of its hydrogel network and high oxygen‐carrying capacity originated by the water‐swollen and water‐holding characteristics of starch. This resulted in a decrease in the auto‐quenching...

article

Optimal Design for the Rear-Glass Joint of an Automobile for Squeak and Rattle Noise Reduction

Keon Hee Baek, Su Bin Choi, Hee Rok Hong, Nak Tak Jeong, more

International Journal of Automotive Technology > 2018 > 19 > 5 > 859-868

Ever since vehicle noise, vibration, and harshness (NVH) reduction technology made dramatic improvements, vehicle interior noises represented by Squeak and Rattle (S/R) becomes an ever more important factor to improve the emotional quality of vehicles. Generally, people detect S/R noises on automotive interior parts, brake system, suspension, Body in White (BIW), etc. Among them, the rear-glass joint...

article

pH-Responsive hyaluronated liposomes for docetaxel delivery

Jae Min Lee, Hongsuk Park, Kyung Taek Oh, Eun Seong Lee

International Journal of Pharmaceutics > 2018 > 547 > 1-2 > 377-384

In this study, we report pH-responsive liposomes consisting of hydrogenated soy phosphatidylcholine (HSPC) as a lipid, hyaluronic acid (HA) grafted with functional 3-diethylaminopropyl (DEAP) groups (hereafter denoted as HA-g-DEAP) as a pH-responsive polymer, and docetaxel (DTX) as an antitumor drug. DTX-loaded HSPC liposomes were prepared via a conventional liposome manufacturing procedure and then...

article

pH‐responsive starch microparticles for a tumor‐targeting implant

Seong Kyeong Kim, Hongsuk Park, Jae Min Lee, Kun Na, more

Polymers for Advanced Technologies > 29 > 5 > 1372 - 1376

Much progress has been made toward stimuli‐responsive polysaccharide‐based selective tumor therapy not only because polysaccharides have nontoxic biodegradability and biocompatibility but also because their stimuli‐sensitive characteristics enable the proper transport of payloads into tumors. Here, we attempted to deliver an antitumor drug, doxorubicin (DOX), using starch‐based microparticles coupled...

article

Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

Guk Young Ahn, Dong-Hyun Paik, Ki-Young Jeong, Seung-Woon Baek, more

Macromolecular Research > 2018 > 26 > 7 > 573-576

We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over...

article

γ-Cyclodextrin-phenylacetic acid mesh as a drug trap

Hyeong Sup Yu, Jae Min Lee, Yu Seok Youn, Kyung Taek Oh, more

Carbohydrate Polymers > 2018 > 184 > C > 390-400

In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture...

article

Development of pH‐sensitive nanogels for cancer treatment using crosslinked poly(aspartic acid‐graft‐imidazole)‐block‐poly(ethylene glycol)

Taehoon Sim, Chaemin Lim, Young Hun Cho, Eun Seong Lee, more

Journal of Applied Polymer Science > 135 > 20 > n/a - n/a

pH‐sensitive nanogels (NGs) based on poly(aspartic acid‐graft‐imidazole)‐poly(ethylene glycol) were developed using linear PEG with different molecular weights (2000 and 4000 Da) as crosslinkers. The pH‐sensitive NGs showed reversible size changes during continuously alternating pH changes. The anticancer treatment potential of pH‐sensitive NGs was studied using a model drug, irinotecan (IRI). IRI‐loaded...

article

Hyaluronate dots for highly efficient photodynamic therapy

Eun Jung Choi, Jae Min Lee, Yu Seok Youn, Kun Na, more

Carbohydrate Polymers > 2018 > 181 > C > 10-18

Nanoscale particles, such as quantum dots and carbon dots, are important materials for use in sensing and treating irregular biological events, but their versatility for biomedical applications are usually limited by their undesirable properties such toxicity and non-degradability. Here, we report biofunctional hyaluronic acid (HA) dots containing biodegradable/biocompatible HA. HA dots were prepared...

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INFONA - science communication portal

Search results for: Eun Seong Lee

Singlet oxygen‐responsive hyaluronate dot clusters for tumor therapy

pH‐dependent swellable hyaluronate nanogels targeting acidic tumors

Polymyxin B/chlorine e6 conjugated hyaluronate dot particles for antimicrobial photodynamic therapy

Development of biocompatible electrostatic‐repulsive microparticles for local tumor treatment

The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks

Development of pH‐responsive cyclodextrin nanoparticles for tumor‐specific photodynamic therapy

Development of Three Driver State Detection Models from Driving Information Using Vehicle Simulator; Normal, Drowsy and Drunk Driving

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

A pH-Sensitive Polymer for Cancer Targeting Prepared by One-Step Modulation of Functional Side Groups

Loosening mechanism of threaded fastener for complex structures

Regional glucose metabolism due to the presence of cerebral amyloidopathy in older adults with depression and mild cognitive impairment

Chlorin e6‐embedded starch nanogels for improved photodynamic tumor ablation

Optimal Design for the Rear-Glass Joint of an Automobile for Squeak and Rattle Noise Reduction

pH-Responsive hyaluronated liposomes for docetaxel delivery

pH‐responsive starch microparticles for a tumor‐targeting implant

Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

γ-Cyclodextrin-phenylacetic acid mesh as a drug trap

Development of pH‐sensitive nanogels for cancer treatment using crosslinked poly(aspartic acid‐graft‐imidazole)‐block‐poly(ethylene glycol)

Hyaluronate dots for highly efficient photodynamic therapy

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