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Motility of malignant cells plays a crucial role for the metastasis of tumours. Both, 17-β-estradiol and transforming growth factor-β (TGF-β), induce migration of MCF-7 breast cancer cells and simultaneous treatment resulted in an additive effect of the migratory response. But most interestingly, when cells were preincubated with 17-β-estradiol, the ability of TGF-β to evoke chemotaxis was drastically...
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