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The genome of eukaryotic cells is frequently exposed to damage by various genotoxins. Phosphorylation of histone H2AX at Serine 139 (γ‐H2AX) is a hallmark of DNA damage. RNF8 monoubiquitinates γ‐H2AX with the Lys63‐linked ubiquitin chain to tether DNA repair molecules at DNA lesions. A high‐throughput screening identified RNF8 as a binding partner of dual‐specificity tyrosine phosphorylation‐regulated...
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