Search results for: Allan S. Hoffman

Items from 1 to 20 out of 74 results

article

Corrigendum to “The early days of PEG, PEGylation (1970s–1990s)” [Acta Biomater. 40 (2016) 1–5]

Allan S. Hoffman

Acta Biomaterialia > 2017 > 49 > C > 606

article

The early days of PEG and PEGylation (1970s–1990s)

Allan S. Hoffman

Acta Biomaterialia > 2016 > 40 > C > 1-5

The idea to conjugate PEG [poly(ethylene glycol)] to a protein, i.e., to “PEGylate” a protein, was first proposed by Prof. Frank Davis (Rutgers Univ.) in the late 1960s. He wanted to make the new recombinant proteins less immunogenic in our bodies, and thereby enhance their circulation and activity lifetimes. He thought that if he could conjugate a hydrophilic polymer to the “new” protein, it might...

article

Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Hyeonjeong Jeon, Jihoon Kim, Yeong Mi Lee, Jinhwan Kim, more

Journal of Controlled Release > 2016 > 231 > C > 68-76

This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron...

chapter

Ionizing radiation and gas plasma (or glow) discharge treatments for preparation of novel polymeric biomaterials

Allan S. Hoffman

Advances in Polymer Science > Polymers in Medicine > 141-157

There is a wide variety of materials which are foreign to the body and which are used in contact with body fluids. These materials are called biomaterials. By far, the most diverse use of biomaterials exists within the polymer class: in these organic materials, ionizing radiation and plasma discharges have a unique ability to initiate free radical and ionic reactions without the need to add...

article

In situ-forming injectable hydrogels for regenerative medicine

Jeong-A. Yang, Junseok Yeom, Byung Woo Hwang, Allan S. Hoffman, more

Progress in Polymer Science > 2014 > 39 > 12 > 1973-1986

Regenerative medicine involves interdisciplinary biomimetic approaches for cell therapy and tissue regeneration, employing the triad of cells, signals, and/or scaffolds. Remarkably, the field of therapeutic cells has evolved from the use of embryonic and adult stem cells to the use of induced pluripotent stem cells. For application of these cells in regenerative medicine, cell fate needs to be carefully...

article

NanoDDS 2013: The 11th International Nano Drug Delivery Symposium

J. Andrew MacKay, Adah Almutairi, Wim Hennink, Allan S. Hoffman

Journal of Controlled Release > 2014 > 191 > Complete > 1-3

article

Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors

Nicholas A. Peppas, Ruth Duncan, Gary E. Wnek, Allan S. Hoffman, more

Journal of Controlled Release > 2014 > 190 > Complete > 29-30

To celebrate the success of the Journal of Controlled Release and the research covered in the journal, here we highlight some of the most cited research articles in the history of the journal. Based on the literature search in Google Scholar in July 2013, we identified ~30 research articles that have received most number of citations. Authors of these articles were invited to provide a commentary...

article

Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors

Nicholas A. Peppas, Ruth Duncan, Gary E. Wnek, Allan S. Hoffman, more

Journal of Controlled Release > 2014 > 190 > C > 29-74

article

Biomaterials in the nano-era

Allan S. Hoffman

Chinese Science Bulletin > 2013 > 58 > 35 > 4337-4341

This article is a brief summary of my plenary talk at the World Biomaterials Congress in Chengdu, Sichuan, China, June 1–5, 2012. It highlights the trend to design and develop biomaterial implants and devices that are more compact and more efficient, as they “shrink” from the macro- to the micro- and down to the nano-scale.

article

Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation

Allan S. Hoffman

Advanced Drug Delivery Reviews > 2013 > 65 > 1 > 10-16

Over the past 25years many interesting biomedical uses have been proposed for stimuli-responsive polymers, including uses in diagnostics, drug delivery, tissue engineering (regenerative medicine), and cell culture. This article briefly overviews the field of stimuli-responsive polymers and describes some of the most successful biomedical applications to date of such “smart” polymers. Other interesting...

article

Hydrogels for biomedical applications

Allan S. Hoffman

Advanced Drug Delivery Reviews > 2012 > 64 > S > 18-23

This article reviews the composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices. The most important properties of hydrogels relevant to their biomedical applications are also identified, especially for use of hydrogels as drug and cell carriers, and as tissue engineering matrices.

article

Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

Jong-Ho Kim, Sang Mun Bae, Moon-Hee Na, Hyeri Shin, more

Journal of Controlled Release > 2012 > 157 > 3 > 493-499

Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular...

article

Preparation and characterization of poly(vinyl alcohol) hydrogel based three-dimensional dosimeter for radiotherapy

Peng Du, Jie Chen, Liming Yang, Wenyun Luo, more

Journal of Controlled Release > 2011 > 152 > S1 > e193-e195

article

RAFT-synthesized graft copolymers that enhance pH-dependent membrane destabilization and protein circulation times

Emily Crownover, Craig L. Duvall, Anthony Convertine, Allan S. Hoffman, more

Journal of Controlled Release > 2011 > 155 > 2 > 167-174

Here we describe a new graft copolymer architecture of poly(propylacrylic acid) (polyPAA) that displays potent pH-dependent, membrane-destabilizing activity and in addition is shown to enhance protein blood circulation kinetics. PolyPAA containing a single telechelic alkyne functionality was prepared via reversible addition–fragmentation chain transfer (RAFT) polymerization with an alkyne–functional...

article

In situ dose amplification by apoptosis-targeted drug delivery

Kai Wang, Moon-Hee Na, Allan S. Hoffman, Gayong Shim, more

Journal of Controlled Release > 2011 > 154 > 3 > 214-217

When tumor cells undergo apoptosis in response to chemotherapy, the levels of apoptotic biomarkers such as histone H1 are increased at the tumor. This would amplify in situ homing signals and thus drug delivery by apoptosis-targeted drugs. To examine this possibility, we prepared apoptosis-targeted liposomes containing doxorubicin by labeling them with the CQRPPR peptide (ApoPep-1) that recognizes...

article

Remembering Professor Tae Gwan Park (1957–2011)

Haeshin Lee, Ji Hoon Jeong, Allan S. Hoffman

Bioconjugate Chemistry > 2011 > 22 > 7 > 1257 - 1258

article

A Novel Peptide Probe for Imaging and Targeted Delivery of Liposomal Doxorubicin to Lung Tumor

Xiaofeng He, Moon-Hee Na, Jin-Sook Kim, Ga-Young Lee, more

Molecular Pharmaceutics > 2011 > 8 > 2 > 430 - 438

article

Efficient intracellular delivery of a pro-apoptotic peptide with a pH-responsive carrier

Brian Albarran, Allan S. Hoffman, Patrick S. Stayton

Reactive and Functional Polymers > 2011 > 71 > 3 > 261-265

A key challenge in developing protein therapeutics or imaging agents that work against cytosolic targets is the intracellular delivery barrier. Here, we show that the pH-responsive, membrane-destabilizing polymer, poly(propylacrylic acid) (PPAA), can strongly enhance target cell killing through the intracellular delivery of a functional pro-apoptotic peptide. The Bak BH3 peptide induces apoptosis...

article

In vivo imaging of tumor apoptosis using histone H1-targeting peptide

Kai Wang, Sangeetha Purushotham, Ji-Young Lee, Moon-Hee Na, more

Journal of Controlled Release > 2010 > 148 > 3 > 283-291

In vivo imaging of apoptosis could allow monitoring of tumor response to cancer treatments such as chemotherapy. Using phage display, we identified the CQRPPR peptide, named ApoPep-1(Apoptosis-targeting Peptide-1), that was able to home to apoptotic and necrotic cells in tumor tissue. ApoPep-1 also bound to apoptotic and necrotic cells in culture, while only little binding to live cells was observed...

article

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

Suzanne Foster, Craig L. Duvall, Emily F. Crownover, Allan S. Hoffman, more

Bioconjugate Chemistry > 2010 > 21 > 12 > 2205 - 2212

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Search results for: Allan S. Hoffman

Corrigendum to “The early days of PEG, PEGylation (1970s–1990s)” [Acta Biomater. 40 (2016) 1–5]

The early days of PEG and PEGylation (1970s–1990s)

Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Ionizing radiation and gas plasma (or glow) discharge treatments for preparation of novel polymeric biomaterials

In situ-forming injectable hydrogels for regenerative medicine

NanoDDS 2013: The 11th International Nano Drug Delivery Symposium

Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors

Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors

Biomaterials in the nano-era

Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation

Hydrogels for biomedical applications

Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

Preparation and characterization of poly(vinyl alcohol) hydrogel based three-dimensional dosimeter for radiotherapy

RAFT-synthesized graft copolymers that enhance pH-dependent membrane destabilization and protein circulation times

In situ dose amplification by apoptosis-targeted drug delivery

Remembering Professor Tae Gwan Park (1957–2011)

A Novel Peptide Probe for Imaging and Targeted Delivery of Liposomal Doxorubicin to Lung Tumor

Efficient intracellular delivery of a pro-apoptotic peptide with a pH-responsive carrier

In vivo imaging of tumor apoptosis using histone H1-targeting peptide

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

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