Search results for: Steven W. Graves

Items from 1 to 20 out of 45 results

article

Simple and inexpensive micromachined aluminum microfluidic devices for acoustic focusing of particles and cells

Gayatri P. Gautam, Tobias Burger, Andrew Wilcox, Michael J. Cumbo, more

Analytical and Bioanalytical Chemistry > 2018 > 410 > 14 > 3385-3394

We introduce a new method to construct microfluidic devices especially useful for bulk acoustic wave (BAW)-based manipulation of cells and microparticles. To obtain efficient acoustic focusing, BAW devices require materials that have high acoustic impedance mismatch relative to the medium in which the cells/microparticles are suspended and materials with a high-quality factor. To date, silicon and...

article

Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies

Esra Mutlu, Tim Cristy, Steven W. Graves, Michelle J. Hooth, more

Environmental Science and Pollution Research > 2017 > 24 > 1 > 405-416

Tetravalent (V^IV) and pentavalent (V^V) forms of vanadium were selected for testing by the National Toxicology Program via drinking water exposure due to potential human exposure. To aid in the test article selection, drinking water formulations (125–2000 mg/L) of vanadyl sulfate (V^IV), sodium orthovanadate, and sodium metavanadate (V^V) were characterized by ultraviolet/visible (UV/VIS) spectroscopy,...

article

Global “omics” evaluation of human placental responses to preeclamptic conditions

Komal Kedia, Stephen F. Smith, Andrew H. Wright, Justin M. Barnes, more

American Journal of Obstetrics and Gynecology > 2016 > 215 > 2 > 238.e1-238.e20

Preeclampsia (PE) is a leading cause of maternal death. Its cause is still debated but there is general agreement that the placenta plays a central role. Perhaps the most commonly proposed contributors to PE include placental hypoxia, oxidative stress, and increased proinflammatory cytokines. How the placenta responds to these abnormalities has been considered but not as part of a comprehensive analysis...

article

572: Detection and confirmation of early gestation, serum lipidomic biomarkers for preeclampsia

Steven W. Graves, Swati Anand, Sydney Young, Dennis H. Tolley, more

American Journal of Obstetrics and Gynecology > 2016 > 214 > 1 Supplement > S308

article

Purification and characterization of lipopolysaccharides from six strains of non-O157 Shiga toxin-producing Escherichia coli

Loreen R. Stromberg, Zachary R. Stromberg, Afsheen Banisadr, Steven W. Graves, more

Journal of Microbiological Methods > 2015 > 116 > C > 1-7

Certain Shiga toxin-producing Escherichia coli (STEC) are virulent human pathogens that are most often acquired through contaminated food. The United States Department of Agriculture, Food Safety and Inspection Service has declared several serogroups of STEC as adulterants in non-intact raw beef products. Hence, sensitive and specific tests for the detection of these STEC are a necessity for implementation...

article

Novel “omics” approach for study of low-abundance, low-molecular-weight components of a complex biological tissue: regional differences between chorionic and basal plates of the human placenta

Komal Kedia, Caitlin A. Nichols, Craig D. Thulin, Steven W. Graves

Analytical and Bioanalytical Chemistry > 2015 > 407 > 28 > 8543-8556

Tissue proteomics has relied heavily on two-dimensional gel electrophoresis, for protein separation and quantification, then single protein isolation, trypsin digestion, and mass spectrometric protein identification. Such methods are predominantly used for study of high-abundance, full-length proteins. Tissue peptidomics has recently been developed but is still used to study the most highly abundant...

article

Signal Propagation in Multi‐Layer DNAzyme Cascades Using Structured Chimeric Substrates

Carl W. Brown, Matthew R. Lakin, Eli K. Horwitz, M. Leigh Fanning, more

Angewandte Chemie > 126 > 28 > 7311 - 7315

Signal propagation through enzyme cascades is a critical component of information processing in cellular systems. Although such systems have potential as biomolecular computing tools, rational design of synthetic protein networks remains infeasible. DNA strands with catalytic activity (DNAzymes) are an attractive alternative, enabling rational cascade design through predictable base‐pair hybridization...

article

Signal Propagation in Multi‐Layer DNAzyme Cascades Using Structured Chimeric Substrates

Carl W. Brown, Matthew R. Lakin, Eli K. Horwitz, M. Leigh Fanning, more

Angewandte Chemie International Edition > 53 > 28 > 7183 - 7187

article

Association of cord blood digitalis-like factor and necrotizing enterocolitis

Steven W. Graves, Michael S. Esplin, Paula McGee, Dwight J. Rouse, more

American Journal of Obstetrics and Gynecology > 2014 > 210 > 4 > 328.e1-328.e5

Endogenous digoxin-like factor (EDLF) has been linked to vasoconstriction, altered membrane transport, and apoptosis. Our objective was to determine whether increased EDLF in the cord sera of preterm infants was associated with an increased incidence of necrotizing enterocolitis (NEC).Cord sera from pregnant women enrolled in a randomized trial of MgSO₄ for fetal neuroprotection were analyzed for EDLF...

article

Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice

Suramya Waidyanatha, Jerry D. Johnson, S. Peter Hong, Veronica Godfrey Robinson, more

Toxicology and Applied Pharmacology > 2013 > 271 > 2 > 216-228

Plants containing thujone have widespread use and hence have significant human exposure. α-Thujone caused seizures in rodents following gavage administration. We investigated the toxicokinetics of α-thujone in male and female F344/N rats and B6C3F1 mice following intravenous and gavage administration of α-thujone or a mixture of α- and β-thujone (which will be referred to as α,β-thujone). Absorption...

article

Digoxin antibody fragment, antigen binding (Fab), treatment of preeclampsia in women with endogenous digitalis-like factor: a secondary analysis of the DEEP Trial

Garrett K. Lam, Moana Hopoate-Sitake, C. David Adair, Vardaman M. Buckalew, more

American Journal of Obstetrics and Gynecology > 2013 > 209 > 2 > 119.e1-119.e6

Endogenous digitalis-like factors (EDLFs) are elevated in women with preeclampsia, and the use of an anti-digoxin antibody Fab (DIF) in women with preeclampsia who were remote from term reduced maternal blood pressure and preserved renal function. The objective was to determine whether DIF treatment in women with severe preeclampsia in association with positive EDLFs in maternal serum improves maternal-perinatal...

article

Tissue proteomics of the low‐molecular weight proteome using an integrated cLC‐ESI‐QTOFMS approach

MeiHwa Tanielle Bench Alvarez, Dipti Jigar Shah, Craig D. Thulin, Steven W. Graves

PROTEOMICS > 13 > 9 > 1400 - 1411

Analysis of the protein/peptide composition of tissue has provided meaningful insights into tissue biology and even disease mechanisms. However, little has been published regarding top down methods to investigate lower molecular weight (MW) (500–5000 Da) species in tissue. Here, we evaluate a tissue proteomics approach involving tissue homogenization followed by depletion of large proteins and then...

article

One-dimensional acoustic standing waves in rectangular channels for flow cytometry

Pearlson P. Austin Suthanthiraraj, Menake E. Piyasena, Travis A. Woods, Mark A. Naivar, more

Methods > 2012 > 57 > 3 > 259-271

Flow cytometry has become a powerful analytical tool for applications ranging from blood diagnostics to high throughput screening of molecular assemblies on microsphere arrays. However, instrument size, expense, throughput, and consumable use limit its use in resource poor areas of the world, as a component in environmental monitoring, and for detection of very rare cell populations. For these reasons,...

article

Cluster cytometry for high‐capacity bioanalysis

Bruce S. Edwards, Jingshu Zhu, Jun Chen, Mark B. Carter, more

Cytometry Part A > 81A > 5 > 419 - 429

Flow cytometry specializes in high‐content measurements of cells and particles in suspension. Having long excelled in analytical throughput of single cells and particles, only recently with the advent of HyperCyt sampling technology, flow cytometry's multiexperiment throughput has begun to approach the point of practicality for efficiently analyzing hundreds‐of‐thousands of samples, the realm of high‐throughput...

article

Binding and cell intoxication studies of anthrax lethal toxin

Momchilo Vuyisich, Claire K. Sanders, Steven W. Graves

Molecular Biology Reports > 2012 > 39 > 5 > 5897-5903

Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. The vast majority of the anthrax toxin-related literature describes the assembly of LT as a cell-dependent process. However, some reports have provided evidence for the existence of a fully assembled LT, either in vitro or in the bloodstream of anthrax-infected animals. To follow up on this work, we present studies on fully-assembled...

article

Rapid Evaluation of the Antibacterial Activity of Arylene–Ethynylene Compounds

Thomas S. Corbitt, Zhijun Zhou, Yanli Tang, Steven W. Graves, more

ACS Applied Materials & Interfaces > 2011 > 3 > 8 > 2938 - 2943

article

80: Validation of predictive preterm birth biomarkers obtained by maternal serum proteomics

Steven W. Graves, M. Sean Esplin

American Journal of Obstetrics and Gynecology > 2011 > 204 > 1 Supplement > S46

article

T10.5 Digoxin Immune Fab treatment for severe preclampsia; relationship between response and baseline endogenous digitalis-like factor

C. David Adair, Vardaman Buckalew, Steven W. Graves, Nikhil Chauhan, more

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2010 > 1 > Supplement 1 > S21

article

M14.1 Human placental digitalis-like factor in preeclampsia and its potential regulation

Steven W. Graves, Jie Ma, C. David Adair, Lorrie Mason

Pregnancy Hypertension: An International Journal of Women's Cardiovascular... > 2010 > 1 > Supplement 1 > S11

article

High-Resolution Spectral Analysis of Individual SERS-Active Nanoparticles in Flow

Gregory Goddard, Leif O. Brown, Robb Habbersett, Christina I. Brady, more

Journal of the American Chemical Society > 2010 > 132 > 17 > 6081 - 6090

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INFONA - science communication portal

Search results for: Steven W. Graves

Simple and inexpensive micromachined aluminum microfluidic devices for acoustic focusing of particles and cells

Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies

Global “omics” evaluation of human placental responses to preeclamptic conditions

572: Detection and confirmation of early gestation, serum lipidomic biomarkers for preeclampsia

Purification and characterization of lipopolysaccharides from six strains of non-O157 Shiga toxin-producing Escherichia coli

Novel “omics” approach for study of low-abundance, low-molecular-weight components of a complex biological tissue: regional differences between chorionic and basal plates of the human placenta

Signal Propagation in Multi‐Layer DNAzyme Cascades Using Structured Chimeric Substrates

Signal Propagation in Multi‐Layer DNAzyme Cascades Using Structured Chimeric Substrates

Association of cord blood digitalis-like factor and necrotizing enterocolitis

Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice

Digoxin antibody fragment, antigen binding (Fab), treatment of preeclampsia in women with endogenous digitalis-like factor: a secondary analysis of the DEEP Trial

Tissue proteomics of the low‐molecular weight proteome using an integrated cLC‐ESI‐QTOFMS approach

One-dimensional acoustic standing waves in rectangular channels for flow cytometry

Cluster cytometry for high‐capacity bioanalysis

Binding and cell intoxication studies of anthrax lethal toxin

Rapid Evaluation of the Antibacterial Activity of Arylene–Ethynylene Compounds

80: Validation of predictive preterm birth biomarkers obtained by maternal serum proteomics

T10.5 Digoxin Immune Fab treatment for severe preclampsia; relationship between response and baseline endogenous digitalis-like factor

M14.1 Human placental digitalis-like factor in preeclampsia and its potential regulation

High-Resolution Spectral Analysis of Individual SERS-Active Nanoparticles in Flow

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