Search results for: Hideaki Takahashi

Items from 1 to 20 out of 166 results

article

Lymphatic Capillarization in Different Fiber Types of Rat Skeletal Muscles With Growth and Age

Yoshikazu Taketa, Keigo Tamakoshi, Kazuki Hotta, Shutaro Maki, more

Objective To clarify the effect of growth and advancing age on lymphatic capillarization in rat skeletal muscles, we examined the histological and biochemical changes of lymphatic capillaries in different fiber types of skeletal muscles across juvenile, young, and middle‐aged generations. Methods We collected the tibialis anterior (TA), extensor digitorum longus (EDL), and soleus (SOL) muscles...

article

Effect of HER2‐targeted therapy on PDX and PDX‐derived organoids generated from HER2‐positive salivary duct carcinoma

Jun Aoyama, Yusuke Nojima, Daisuke Sano, Yuri Hirai, more

Head & Neck > 45 > 7 > 1801 - 1811

Background We previously established a patient‐derived xenograft (PDX) model, patient‐derived organoids (PDOs), and PDX‐derived organoids (PDXOs) for salivary duct carcinoma (SDC). Using these models, this study examined the therapeutic effect of human epidermal growth factor receptor 2 (HER2) blockade on HER2‐positive SDC. Methods The therapeutic effect of lapatinib was assessed in SDC PDXOs with...

article

Development of Kinetic Energy Density Functional Using Response Function Defined on the Energy Coordinate

Hideaki Takahashi

International Journal of Quantum Chemistry > 122 > 20 > n/a - n/a

article

Development of kinetic energy density functional using response function defined on the energy coordinate

Hideaki Takahashi

International Journal of Quantum Chemistry > 122 > 20 > n/a - n/a

A kinetic energy functional

E_{kin}^{e}

was developed within the framework of the density‐functional theory (DFT) based on the energy electron density for the purpose of realizing the orbital‐free DFT. The functional includes the nonlocal term described with the linear‐response function (LRF) of a reference system. As a notable feature of the present approach, the LRF is represented on the energy coordinate...

article

The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi‐institutional retrospective analysis in Japan

Kimihide Kusafuka, Yoko Sato, Eiji Nakatani, Satoshi Baba, more

Head & Neck > 44 > 6 > 1430 - 1441

Background Salivary duct carcinoma (SDC) is a high‐grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC. Methods We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes. Results The median age of the...

article

Low doses of methylnaltrexone inhibits head and neck squamous cell carcinoma growth in vitro and in vivo by acting on the mu‐opioid receptor

Aysegul Gorur, Miguel Patiño, Ted Shi, German Corrales, more

Journal of Cellular Physiology > 236 > 11 > 7698 - 7710

The Mu‐opioid receptor (MOR) has been implicated in tumorigenesis and metastasis. Methylnaltrexone (MNTX), an antagonist of MOR, has shown to inhibit tumor growth and metastasis in lung cancer cell lines. The effect of MNTX on other cell lines such as head and neck squamous cell carcinoma (HNSCC) has not been investigated. We measured the expression and activity of the receptor in different HNSCC...

article

Age‐based efficacy and safety of nivolumab for recurrent or metastatic head and neck squamous cell carcinoma: A multicenter retrospective study

Takahito Kondo, Isaku Okamoto, Hiroki Sato, Nobuyuki Koyama, more

Asia‐Pacific Journal of Clinical Oncology > 16 > 6 > 340 - 347

Aim This study retrospectively investigated the efficacy and safety of nivolumab for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) classified using age <65 years as the cutoff. Methods Overall, 88 patients with R/M HNSCC treated with nivolumab were classified into the young group (<65 years; n = 39) and elderly group (≥65 years; n = 49). Efficacy...

article

Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method

Kentaro Takada, Yoshihiro Aizawa, Daisuke Sano, Ryo Okuda, more

International Journal of Cancer > 148 > 1 > 193 - 202

To generate a reliable preclinical model system exhibiting the molecular features of salivary adenoid cystic carcinoma (ACC) whose biology is still unclear due to the paucity of stable cell cultures. To develop new in vitro and in vivo models of ACC, the techniques of organoid culture and patient‐derived tumor xenograft (PDX), which have attracted attention in other malignancies in recent years, were...

article

Prognostic performance of the American Joint Committee on Cancer 8th edition of the TNM staging system in patients with early oral tongue cancer

Moran Amit, Samantha Tam, Hideaki Takahashi, Karen Y. Choi, more

Head & Neck > 41 > 5 > 1270 - 1276

Background The 8th edition of the American Joint Committee on Cancer's (AJCC) staging system for oral cavity cancer incorporates pathological features. We aimed to assess whether these changes results in better risk stratification of patients with early oral tongue squamous cell carcinoma (OTSCC). Methods Overall survival (OS) and disease‐specific survival (DSS) of 244 patients were calculated...

article

Classification of tumors by imaging diagnosis and preoperative fine‐needle aspiration cytology in 120 patients with tumors in the parapharyngeal space

Takashi Matsuki, Kouki Miura, Yuichiro Tada, Tatsuo Masubuchi, more

Head & Neck > 41 > 5 > 1277 - 1281

Background Tumors in the parapharyngeal space are rare, and preoperative diagnosis is difficult because of anatomical and histological complexity. Methods To evaluate the usefulness of preoperative diagnosis, we compared the classification of tumor localization in the prestyloid and retrostyloid compartments by imaging and preoperative cytological diagnosis by fine‐needle aspiration cytology with...

article

First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors

Toshihiko Doi, Kiyotaka Yoh, Kohei Shitara, Hideaki Takahashi, more

Investigational New Drugs > 2019 > 37 > 3 > 507-518

Summary Background This first-in-human phase 1 study assessed the safety of TAS-114, a novel deoxyuridine triphosphatase inhibitor, combined with S-1 to determine its maximum tolerated dose (MTD) and recommended dose (RD). Methods In this dose-escalation study with a 3 + 3 design, TAS-114 and S-1 were concurrently administered orally under fasting conditions at 5–240 mg/m² and 30–36 mg/m², respectively,...

article

Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment

Hideki Wakasugi, Hideaki Takahashi, Takeshi Niinuma, Hiroshi Kitajima, more

Cancer Letters > 2018 > 434 > C > 91-100

Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC). Nucleos(t)ide analogue (NA) therapy effectively reduces the incidence of HCC, but it does not completely prevent the disease. Here, we show that dysregulation of microRNAs (miRNAs) is involved in post-NA HCC development. We divided chronic hepatitis B (CHB) patients who received NA therapy into two groups: 1) those...

article

Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy

Yuko Suzuki, Motoyasu Kan, Gen Kimura, Kumiko Umemoto, more

Journal of Gastroenterology > 2019 > 54 > 3 > 281-290

Background Few studies have clearly identified the prognostic factors in patients with advanced biliary tract cancer (BTC) receiving gemcitabine plus cisplatin (GC) which is acknowledged as standard chemotherapy regimen. Objectives The aim of this study was to identify predictive factors of the overall survival (OS) in advanced BTC patients receiving GC therapy. Methods Data of 307 patients with...

article

Efficacy of ledipasvir/sofosbuvir with or without ribavirin for 12 weeks in genotype 1b HCV patients previously treated with a nonstructural protein 5A inhibitor‐containing regimen

Hiroki Ikeda, Tsunamasa Watanabe, Hirohito Shimizu, Tetsuya Hiraishi, more

Hepatology Research > 48 > 10 > 802 - 809

Aim The therapeutic benefit of adding ribavirin (RBV) to 12 weeks of ledipasvir/sofosbuvir (LDV/SOF) for patients who experienced failure of a previous nonstructural protein (NS) 5A inhibitor‐containing regimen is unclear. Methods A total of 29 genotype 1b HCV patients who had failed prior daclatasvir (DCV) plus asunaprevir (ASV) treatment were retreated for 12 weeks of LDV/SOF, with or without...

article

Phase I study of resminostat, an HDAC inhibitor, combined with S-1 in patients with pre-treated biliary tract or pancreatic cancer

Masafumi Ikeda, Izumi Ohno, Hideki Ueno, Shuichi Mitsunaga, more

Investigational New Drugs > 2019 > 37 > 1 > 109-117

Summary Resminostat is an oral hydroxamate inhibitor of class I, IIb, and IV histone deacetylases. S-1 is widely used to treat biliary tract cancer and pancreatic cancer in Japan. We performed a phase I study of resminostat combined with S-1 as second-line or later therapy in Japanese patients with biliary tract or pancreatic cancer. A total of 27 patients were enrolled. We determined the optimal...

article

Mo1346 THERAPEUTIC EFFECTS OF ENDOSCOPIC ULTRASOUND-GUIDED CELIAC NEUROLYSIS (EUS-CPN) IN PATIENTS WITH UPPER ABDOMINAL-ASSOCIATED PAIN (UAP)

Gen Kimura, Yusuke Hashimoto, Yuko Suzuki, Kazuo Watanabe, more

Gastrointestinal Endoscopy > 2018 > 87 > 6(S) > AB456

article

Mo1275 EUS-GUIDED HEPATOGASTROSTOMY IS THE LAST RESORT BILIARY DRAINAGE IN MALIGNANT BILIARY OBSTRUCTION AFTER FAILED ERCP

Yusuke Hashimoto, Kumiko Umemoto, Izumi Ohno, Hideaki Takahashi, more

Gastrointestinal Endoscopy > 2018 > 87 > 6(S) > AB425

article

Mo1296 RELIMINARY RESULT OF COMPUTER AIDED DIAGNOSIS (CAD) PERFORMANCE USING DEEP LEARNING IN EUS-FNA CYTOLOGY OF PANCREATIC CANCER

Yusuke Hashimoto, Izumi Ohno, Hiroshi Imaoka, Hideaki Takahashi, more

Gastrointestinal Endoscopy > 2018 > 87 > 6(S) > AB434

article

Characterization of low active ghrelin ratio in patients with advanced pancreatic cancer

Tomofumi Miura, Shuichi Mitsunaga, Masafumi Ikeda, Izumi Ohno, more

Supportive Care in Cancer > 2018 > 26 > 11 > 3811-3817

Purpose Acyl ghrelin is an orexigenic peptide. Active ghrelin ratio, the ratio of acyl ghrelin to total ghrelin, has an important role in physiological functions and gastrointestinal symptoms. However, low active ghrelin ratio-related characteristics, gastrointestinal symptoms, and chemotherapy-induced gastrointestinal toxicity in patients with advanced pancreatic cancer have not been previously evaluated...

article

Effects of Streptomycin Administration on Increases in Skeletal Muscle Fiber Permeability and Size Following Eccentric Muscle Contractions

Keishi Hayao, Hiroyuki Tamaki, Kouki Nakagawa, Keigo Tamakoshi, more

The Anatomical Record > 301 > 6 > 1096 - 1102

The purpose of this study was to investigate the preventive effect of streptomycin (Str) administration on changes in membrane permeability and the histomorphological characteristics of damaged muscle fibers following eccentric contraction (ECC ). Eighteen 7‐week‐old male Fischer 344 rats were randomly assigned to three groups: control (Cont), ECC, and ECC with Str (ECC + Str). The tibialis anterior...

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INFONA - science communication portal

Search results for: Hideaki Takahashi

Lymphatic Capillarization in Different Fiber Types of Rat Skeletal Muscles With Growth and Age

Effect of HER2‐targeted therapy on PDX and PDX‐derived organoids generated from HER2‐positive salivary duct carcinoma

Development of Kinetic Energy Density Functional Using Response Function Defined on the Energy Coordinate

Development of kinetic energy density functional using response function defined on the energy coordinate

The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi‐institutional retrospective analysis in Japan

Low doses of methylnaltrexone inhibits head and neck squamous cell carcinoma growth in vitro and in vivo by acting on the mu‐opioid receptor

Age‐based efficacy and safety of nivolumab for recurrent or metastatic head and neck squamous cell carcinoma: A multicenter retrospective study

Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method

Prognostic performance of the American Joint Committee on Cancer 8th edition of the TNM staging system in patients with early oral tongue cancer

Classification of tumors by imaging diagnosis and preoperative fine‐needle aspiration cytology in 120 patients with tumors in the parapharyngeal space

First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors

Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment

Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy

Efficacy of ledipasvir/sofosbuvir with or without ribavirin for 12 weeks in genotype 1b HCV patients previously treated with a nonstructural protein 5A inhibitor‐containing regimen

Phase I study of resminostat, an HDAC inhibitor, combined with S-1 in patients with pre-treated biliary tract or pancreatic cancer

Mo1346 THERAPEUTIC EFFECTS OF ENDOSCOPIC ULTRASOUND-GUIDED CELIAC NEUROLYSIS (EUS-CPN) IN PATIENTS WITH UPPER ABDOMINAL-ASSOCIATED PAIN (UAP)

Mo1275 EUS-GUIDED HEPATOGASTROSTOMY IS THE LAST RESORT BILIARY DRAINAGE IN MALIGNANT BILIARY OBSTRUCTION AFTER FAILED ERCP

Mo1296 RELIMINARY RESULT OF COMPUTER AIDED DIAGNOSIS (CAD) PERFORMANCE USING DEEP LEARNING IN EUS-FNA CYTOLOGY OF PANCREATIC CANCER

Characterization of low active ghrelin ratio in patients with advanced pancreatic cancer

Effects of Streptomycin Administration on Increases in Skeletal Muscle Fiber Permeability and Size Following Eccentric Muscle Contractions

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