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We previously identified the Gdac1 (Gpx-deficiency-associated colitis 1) locus, which influences the severity of spontaneous colitis in Gpx1- and Gpx2-double-knockout (Gpx1/2-DKO) mice. Congenic Gpx1/2-DKO mice in the 129S1/SvImJ (129) background but carrying the Gdac1B6 allele have milder spontaneous colitis than 129 Gpx1/2-DKO mice carrying the Gdac1129 allele. Here, we evaluated the effect of the...
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