Search results for: Bingling Li

Items from 1 to 20 out of 41 results

article

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Yichen Liu, Yidan Tang, Yin Bao, Kaiwei Cai, more

Angewandte Chemie International Edition > 63 > 19 > n/a - n/a

In order to realize portable pathogen diagnostics with easier quantitation, digitization and integration, we develop a ready‐to‐use electrochemical sensing strategy (Iso‐E‐Codelock) for real‐time detection of isothermal nucleic acid amplification. Bridged by a branched DNA as codelock, the isothermal amplicon is transduced into increased current of an electrochemical probe, holding multiple advantages...

article

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Yichen Liu, Yidan Tang, Yin Bao, Kaiwei Cai, more

Angewandte Chemie > 136 > 19 > n/a - n/a

article

A Duplex Polymerization Strategy for General, Programmable and High‐Resolution Nanopore‐Based Sensing

Ruiping Wu, Yesheng Wang, Jin Yu, Huan Li, more

Angewandte Chemie International Edition > 62 > 30 > n/a - n/a

Nanopore sensing is highly promising in single molecular analysis but their broad applications have been challenged by the limited strategies that can transduce a target‐of‐interest into a specific and anti‐false/inference signal, especially for solid‐state nanopores with relatively lower resolution and higher noise. Here we report a high‐resolution signal‐production concept named target‐induced duplex...

article

A Duplex Polymerization Strategy for General, Programmable and High‐Resolution Nanopore‐Based Sensing

Ruiping Wu, Yesheng Wang, Jin Yu, Huan Li, more

Angewandte Chemie > 135 > 30 > n/a - n/a

article

Base Pair Stacking Modulates Solid‐State Charge Transport in DNA Hairpins

Huili Wang, Yongkang Zhang, Ziang Zhang, Bing Huang, more

Chemistry – A European Journal > 29 > 20 > n/a - n/a

Particular interest has been focused on modulation of solid‐state charge transport (CT) in DNA. Nevertheless, it remains challenging to do so in a sensitive and predictive manner due to the lack of a definite relationship between DNA base pair stacking and DNA CT. The challenges can be mainly attributed to the ill‐defined systems, which may lead to ambiguous and even contradictory conclusions. Here,...

article

Lego‐Like Catalytic Hairpin Assembly Enables Controllable DNA‐Oligomer Formation and Spatiotemporal Amplification in Single Molecular Signaling

Yesheng Wang, Zhentong Zhu, Chunmiao Yu, Ruiping Wu, more

Small > 19 > 4 > n/a - n/a

While the solid‐state nanopore shows increasing potential during sensitive and label‐free single molecular analysis, target concentration and signal amplification method is in urgent need. In this article, a solution via designing a model nucleic acid circuit reaction that can produce “Y” shape‐structure three‐way DNA oligomers with controllable size and polymerization degree is proposed. Such a so‐called...

article

A Rebuilding‐Free Nucleic Acid Detection Strategy Enables Ultrasensitive Genotyping, N‐in‐1 Logic Screening and Accurate Multiplex Assay of Dangerous Pathogens

Huan Li, Huiying Lu, Yidan Tang, Huaning Wang, more

Angewandte Chemie > 134 > 40 > n/a - n/a

Sensitive, rapid and low‐cost nucleic acid detection is critical for controlling infectious pathogens. Here, we develop a ready‐to‐use and multimodal detection based on a rebuilding‐free, ultrasensitive and selective strategy named dual hairpin ligation‐induced isothermal amplification pro (DHLApro). Taking influenza A, influenza B, MERS‐CoV, SARS‐CoV‐2 as model targets, we demonstrate DHLApro provides...

article

A Rebuilding‐Free Nucleic Acid Detection Strategy Enables Ultrasensitive Genotyping, N‐in‐1 Logic Screening and Accurate Multiplex Assay of Dangerous Pathogens

Huan Li, Huiying Lu, Yidan Tang, Huaning Wang, more

Angewandte Chemie International Edition > 61 > 40 > n/a - n/a

article

CLIPON: A CRISPR‐Enabled Strategy that Turns Commercial Pregnancy Test Strips into General Point‐of‐Need Test Devices

Yidan Tang, Lijuan Qi, Yichen Liu, Lulu Guo, more

Angewandte Chemie > 134 > 12 > n/a - n/a

Desirable biosensing assays need to be sensitive, specific, cost‐effective, instrument‐free, and versatile. Herein we report a new strategy termed CLIPON (CRISPR and Large DNA assembly Induced Pregnancy strips for signal‐ON detection) that can deliver these traits. CLIPON integrates a commercial pregnancy test strip (PTS) with four biological elements: the human chorionic gonadotropin (hCG), CRISPR‐Cas12a,...

article

CLIPON: A CRISPR‐Enabled Strategy that Turns Commercial Pregnancy Test Strips into General Point‐of‐Need Test Devices

Yidan Tang, Lijuan Qi, Yichen Liu, Lulu Guo, more

Angewandte Chemie International Edition > 61 > 12 > n/a - n/a

article

HSP70 improves the viability of cryopreserved Paeonia lactiflora pollen by regulating oxidative stress and apoptosis-like programmed cell death events

Ruifen Ren, Xueru Jiang, Wei Di, Zedi Li, more

Plant Cell, Tissue and Organ Culture (PCTOC) > 2019 > 139 > 1 > 53-64

Heat shock proteins (HSPs) have many positive stabilizing effects on the proteins of stressed cells. This study investigated the effect of HSP70 on cryopreserved pollen. HSP70 was differentially expressed in Paeonia lactiflora and Magnolia denudate pollen before and after exposure to liquid nitrogen (LN). In this study, cryopreserved pollen samples of P. lactiflora ‘Fen Yu Nu’, ‘Zi Feng Chao Yang’...

article

Stress and damage mechanisms in Dendrobium nobile Lindl. protocorm-like bodies during pre- and post-liquid nitrogen exposure in cryopreservation revealed by iTRAQ proteomic analysis

Wei Di, Xueru Jiang, Jin Xu, Mengxue Jia, more

In Vitro Cellular & Developmental Biology - Plant > 2018 > 54 > 3 > 253-272

Liquid nitrogen (LN) exposure, a crucial step in cryopreservation, is mainly responsible for the reduced viability of protocorm-like bodies (PLBs) in Dendrobium nobile Lindl. To characterize the stress and damage mechanisms during pre- and post-LN exposure, the isobaric tags for relative and absolute quantification (iTRAQ)-labeling method was used to evaluate proteome profiles of PLBs in D. nobile...

article

Coupling Sensitive Nucleic Acid Amplification with Commercial Pregnancy Test Strips

Yan Du, Arti Pothukuchy, Jimmy D. Gollihar, Armin Nourani, more

Angewandte Chemie International Edition > 56 > 4 > 992 - 996

The detection of nucleic acid biomarkers for point‐of‐care (POC) diagnostics is currently limited by technical complexity, cost, and time constraints. To overcome these shortcomings, we have combined loop‐mediated isothermal amplification (LAMP), programmable toehold‐mediated strand‐exchange signal transduction, and standard pregnancy test strips. The incorporation of an engineered hCG–SNAP fusion...

article

Coupling Sensitive Nucleic Acid Amplification with Commercial Pregnancy Test Strips

Yan Du, Arti Pothukuchy, Jimmy D. Gollihar, Armin Nourani, more

Angewandte Chemie > 129 > 4 > 1012 - 1016

article

An exploratory cross-sectional study on the impact of education on perception of stigma by Chinese patients with schizophrenia

Zhibin Ren, Heqiu Wang, Bin Feng, Chenyu Gu, more

BMC Health Services Research > 2016 > 16 > 1 > 1-7

Background Stigma is a major issue across various society and cultures, and few studies focus on the perception of stigma by Chinese patients with schizophrenia. In the current cross-sectional study, we sought to assess the extent of internalized stigma among outpatients with schizophrenia in China and to investigate whether education level correlated with the experience of stigma. Methods Outpatients...

article

Mismatches Improve the Performance of Strand‐Displacement Nucleic Acid Circuits

Yu Sherry Jiang, Sanchita Bhadra, Bingling Li, Andrew D. Ellington

Angewandte Chemie > 126 > 7 > 1876 - 1879

Catalytic hairpin assembly (CHA) has previously proven useful as a transduction and amplification method for nucleic acid detection. However, the two hairpin substrates in a CHA circuit can potentially react non‐specifically even in the absence of a single‐stranded catalyst, and this non‐specific background degrades the signal‐to‐noise ratio. The introduction of mismatched base pairs that impede uncatalyzed...

article

Mismatches Improve the Performance of Strand‐Displacement Nucleic Acid Circuits

Yu Sherry Jiang, Sanchita Bhadra, Bingling Li, Andrew D. Ellington

Angewandte Chemie International Edition > 53 > 7 > 1845 - 1848

article

Generation of reactive oxygen species during cryopreservation may improve Lilium × siberia pollen viability

Jin Xu, Qian Liu, Mengxue Jia, Yan Liu, more

In Vitro Cellular & Developmental Biology - Plant > 2014 > 50 > 3 > 369-375

During biotic and abiotic stress in plants, reactive oxygen species (ROS) may play two very different roles: high ROS concentrations can exacerbate damage, whereas low concentrations can activate defense responses. The aim of this study was to investigate the relationship between ROS generation and pollen viability after cryopreservation. ROS generation was detected from ‘Siberia’ (Lilium × siberia...

article

In situ labeling and imaging of cellular protein via a bi-functional anticancer aptamer and its fluorescent ligand

Jun Ai, Tao Li, Bingling Li, Yuanhong Xu, more

Analytica Chimica Acta > 2012 > 741 > Complete > 93-99

In this article, we reported a novel approach for in situ labeling and imaging HeLa cancer cells utilizing a bifunctional aptamer (AS1411) and its fluorescent ligand, protoporphyrin IX (PPIX). In the presence of potassium ion, AS1411 folded to G-quadruplex structure, binded fluorescent ligand (PPIX) with fluorescent enhancement, and targeted the nucleolin overexpressed by cancer cells. Consequently,...

chapter

A fully-electronic charge-based DNA sequencing CMOS biochip

Arun Manickam, Rituraj Singh, Nicholas Wood, Bingling Li, more

2012 Symposium on VLSI Circuits (VLSIC) > 126 - 127

2012 IEEE Symposium on VLSI Circuits

A 90×90 fully-electronic biosensor array for charge-based DNA sequence-by-synthesis is implemented in a 0.18µm standard CMOS process. Each 16 µm × 16 µm pixel consists of an integrated charge-sensing electrode connected to an embedded circuitry capable of detecting DNA polymerization and simultaneously measuring the electrode-electrolyte interface capacitance. The detection dynamic range of this sensor...

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INFONA - science communication portal

Search results for: Bingling Li

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

Iso‐E‐Codelock: A Rebuilding‐free Electrochemical Chip with a Customizable Decoding Probe for Real‐Time and Portable Pathogen Diagnostics

A Duplex Polymerization Strategy for General, Programmable and High‐Resolution Nanopore‐Based Sensing

A Duplex Polymerization Strategy for General, Programmable and High‐Resolution Nanopore‐Based Sensing

Base Pair Stacking Modulates Solid‐State Charge Transport in DNA Hairpins

Lego‐Like Catalytic Hairpin Assembly Enables Controllable DNA‐Oligomer Formation and Spatiotemporal Amplification in Single Molecular Signaling

A Rebuilding‐Free Nucleic Acid Detection Strategy Enables Ultrasensitive Genotyping, N‐in‐1 Logic Screening and Accurate Multiplex Assay of Dangerous Pathogens

A Rebuilding‐Free Nucleic Acid Detection Strategy Enables Ultrasensitive Genotyping, N‐in‐1 Logic Screening and Accurate Multiplex Assay of Dangerous Pathogens

CLIPON: A CRISPR‐Enabled Strategy that Turns Commercial Pregnancy Test Strips into General Point‐of‐Need Test Devices

CLIPON: A CRISPR‐Enabled Strategy that Turns Commercial Pregnancy Test Strips into General Point‐of‐Need Test Devices

HSP70 improves the viability of cryopreserved Paeonia lactiflora pollen by regulating oxidative stress and apoptosis-like programmed cell death events

Stress and damage mechanisms in Dendrobium nobile Lindl. protocorm-like bodies during pre- and post-liquid nitrogen exposure in cryopreservation revealed by iTRAQ proteomic analysis

Coupling Sensitive Nucleic Acid Amplification with Commercial Pregnancy Test Strips

Coupling Sensitive Nucleic Acid Amplification with Commercial Pregnancy Test Strips

An exploratory cross-sectional study on the impact of education on perception of stigma by Chinese patients with schizophrenia

Mismatches Improve the Performance of Strand‐Displacement Nucleic Acid Circuits

Mismatches Improve the Performance of Strand‐Displacement Nucleic Acid Circuits

Generation of reactive oxygen species during cryopreservation may improve Lilium × siberia pollen viability

In situ labeling and imaging of cellular protein via a bi-functional anticancer aptamer and its fluorescent ligand

A fully-electronic charge-based DNA sequencing CMOS biochip

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