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Lipopolysaccharide (LPS) increases serum TNF-α levels due to TNF-α secretion by macrophages. The serum TNF-α response to LPS was augmented 10× when FcγR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population responsible for the augmented TNF-α secretion was determined by isolating Kupffer cells, splenic macrophages...
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