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RNA interference (RNAi) using small interfering RNA (siRNA) has been proposed for the therapy of human diseases and in particular cancers. Due to the instability and physicochemical properties of siRNA, the development of siRNA delivery system has attracted much attention. This study aimed at the fabrication of porous silicon nanoparticles (pSi NPs) as carriers for siRNA. pSi NPs possess a high surface...
A new approach for controlling and to functionalise nanoporous anodic alumina oxide (AAO) membranes is described. Our approach is predicated on the remarkable stability of the silanised AAO surface during anodisation. Well ordered nanoporous AAO membranes with different external surface properties compared to the internal pore surface properties were prepared and characterised.
The analysis of membrane domain segregation and phase separation is of significant interest for the understanding of cell membranes. In this paper, we report a new approach to atomic force microscopy (AFM) of artificial membranes, using both functionalised AFM tips and “Force Volume” AFM imaging for the analysis of membrane phase separation. Simultaneous topology and mapping of interaction forces...
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