There is increasing biopharmaceutical interest in oligosaccharides and glycosylation. A key requirement for these sample types is the ability to characterize the chain length, branching, type of monomers, and importantly stereochemistry and anomeric configuration. Herein, we showcase the multi-function capability of a cyclic ion mobility (cIM) separator embedded in a quadrupole/time-of-flight mass...
A novel data‐independent acquisition method is detailed that incorporates a scanning quadrupole in front of an orthogonal acceleration time‐of‐flight (TOF) mass analyser. This approach is described and the attributes are compared and contrasted to other DIA approaches.
Specific application of the method to both targeted and untargeted lipidomic identification strategies is discussed,...
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