Search results for: Xinrong Zhang

Items from 1 to 20 out of 134 results

article

Deubiquitinase Ubp3 regulates ribophagy and deubiquitinates Smo1 for appressorium‐mediated infection by Magnaporthe oryzae

Xuan Cai, Shikun Xiang, Wenhui He, Mengxi Tang, more

Molecular Plant Pathology > 23 > 6 > 832 - 844

The Ubp family of deubiquitinating enzymes has been found to play important roles in plant‐pathogenic fungi, but their regulatory mechanisms are still largely unknown. In this study, we revealed the regulatory mechanism of the deubiquitinating enzyme Ubp3 during the infection process of Magnaporthe oryzae. AUBP3 deletion mutant was severely defective in appressorium turgor accumulation, leading to...

article

Controlling tractor‐semitrailer vehicles in automated highway systems: Adaptive robust and Lyapunov minimax approach

Hao Sun, Luwen Yang, Ye‐Hwa Chen, Xinrong Zhang

Asian Journal of Control > 23 > 6 > 2642 - 2656

In this paper, we design a coordinated steering and braking control scheme to ensure the tractor‐semitrailer vehicle system is practically stable. The tractor's steering input is designed to realize lane tracking and the semitrailer's differential braking torque is designed to improve the stability of the semitrailer. This control methodology is developed in two steps. Firstly, the expected steering...

article

Similarly low risk of hepatocellular carcinoma after either spontaneous or nucleos(t)ide analogue‐induced hepatitis B surface antigen loss

Terry Cheuk‐Fung Yip, Vincent Wai‐Sun Wong, Yee‐Kit Tse, Lilian Yan Liang, more

Alimentary Pharmacology & Therapeutics > 53 > 2 > 321 - 331

Background It is unknown whether patients with chronic hepatitis B (CHB) who achieved hepatitis B surface antigen (HBsAg) seroclearance spontaneously or following anti‐viral therapy have similar clinical outcomes. Aim To compare the risk of hepatocellular carcinoma (HCC) in patients with CHB who either cleared HBsAg spontaneously or following anti‐viral therapy Methods Adult CHB‐monoinfected...

article

Chemical profiling of Honghua Xiaoyao tablet and simultaneous determination of its quality markers by liquid chromatography–tandem mass spectrometry combined with chemometrics methods

Rui Mi, Xiaofeng Li, Zhen Zhang, Taofang Cheng, more

Journal of Separation Science > 43 > 23 > 4263 - 4280

Discovering marker components of traditional Chinese medicine formulas is challenging because of the hundreds of components they inherently contain. This study first proposed a reliable and validated method for the comprehensive profiling of chemical constituents in Honghua Xiaoyao tablet by using high‐performance liquid chromatography coupled with mass spectrometry. After searching within the in‐house...

article

Unhealthy lifestyle habits and physical inactivity among Asian patients with non‐alcoholic fatty liver disease

Xinrong Zhang, George B.‐B. Goh, Wah‐Kheong Chan, Grace L.‐H. Wong, more

Liver International > 40 > 11 > 2719 - 2731

Background & Aims Lifestyle modification is the cornerstone for the management of non‐alcoholic fatty liver disease (NAFLD). We aim to understand lifestyle habits of NAFLD patients, compare across Asian regions and identify area of deficiency. Methods In the multi‐centre controlled attenuation parameter (CAP)‐Asia study, we collected clinical data and lifestyle habit data of NAFLD patients...

article

Simultaneous multicolour imaging using quantum dot structured illumination microscopy

HUI ZENG, HUAIDONG YANG, GUOXUAN LIU, SICHUN ZHANG, more

Journal of Microscopy > 277 > 1 > 32 - 41

Multicolour structured illumination microscopy (SIM) is a powerful tool used for the investigation of the dynamic interaction between subcellular structures. Nevertheless, most of the multicolour SIM schemes are currently limited by conventional fluorescent dyes and wavelength‐dependent optical systems, and can only sequentially record images of different colour channels instead of obtaining multicolour...

article

A VEGFR2–MICA bispecific antibody activates tumor-infiltrating lymphocytes and exhibits potent anti-tumor efficacy in mice

Yao Xu, Xinrong Zhang, Yong Wang, Mingzhu Pan, more

Cancer Immunology, Immunotherapy > 2019 > 68 > 9 > 1429-1441

MHC class I-related chain A (MICA) is one of the major ligands for natural killer group 2 member D (NKG2D), which is an activating NK receptor. MICA is expressed on the surface of human epithelial tumor cells, and its shedding from tumor cells leads to immunosuppression. To activate immune response in the tumor microenvironment, we designed an anti-VEGFR2–MICA bispecific antibody (JZC01), consisting...

article

CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy

Yue Han, Fumou Sun, Xinrong Zhang, Tong Wang, more

Journal of Cancer Research and Clinical Oncology > 2019 > 145 > 5 > 1179-1190

Purpose Bi-specific antibody (BsAb) is an emerging novel format of antibody. We aimed to develop the natural killer (NK) cell receptor NK group 2, member D (NKG2D)-mediated, immune surveillance system. In this system, the NKG2D ligand MHC class I-related chain A (MICA) was fused with BsAb, which targeted a cluster of differentiation 24 (CD24), a tumor-initiating cell marker that is over-expressed...

article

Gold nanoparticles-enhanced ion-transmission mass spectrometry for highly sensitive detection of chemical warfare agent simulants

Lin Zhang, Xu Zhao, Huiyun Cheng, Jinglin Kong, more

Talanta > 2018 > 190 > C > 403-409

Gold nanoparticles (AuNPs)-embedded paper was coupled with ion-transmission mass spectrometry (MS) to enable the highly sensitive detection of chemical warfare agent (CWA) simulants in solutions. With the assistance of a low-temperature plasma (LTP) probe, we found that AuNPs were capable to enhance the ionization efficiencies of target analytes, with MS signal intensities surprisingly undergone an...

article

Ratiometric quantification of β2-microglobulin antigen in human serum based on elemental labeling strategy

Gongwei Sun, Yuqing Zhang, Yi Zhang, Zhian Hu, more

Talanta > 2018 > 189 > C > 249-253

Ratiometric quantification for competitive immunoassay based on internal standard element detection utilizing inductively coupled plasma mass spectrometry (ICP-MS) as multiplex readout has been demonstrated. The Beta-2-microglobulin (β2-MG) associated with clinical diseases was detected by Y-labeled capture antibody used as internal standard probes and Sm-labeled antigen used as report probes via...

article

Mass spectrometry imaging of intact cholesterol in a mouse esophagus tissue section and mouse zygotes using VUV laser desorption/ionization method

Jia Wang, Zhaoying Wang, Feng Liu, Yuxiang Mo, more

International Journal of Mass Spectrometry > 2018 > 432 > C > 9-13

A new instrument based on VUV laser desorption/ionization (VUVDI) method was used to measure the mass spectrum of the cholesterol standard and the mass spectrometry images (MSI) of intact cholesterol in a mouse esophagus tissue section and mouse zygotes. The VUVDI mass spectrum of the cholesterol standard shows dominant peaks from the parent molecules. In the case of the mouse esophagus tissue section,...

article

A cell-penetrating ratiometric probe for simultaneous measurement of lysosomal and cytosolic pH change

Meng-Chan Xia, Lesi Cai, Sichun Zhang, Xinrong Zhang

Talanta > 2018 > 178 > C > 355-361

A new ratiometric fluorescent probe based on cell-penetrating peptides (CPPs) was constructed for whole-cell pH mapping and simultaneous measurement of pH changes in the cytoplasm and lysosomes. The arginine-rich CPP, R₁₂K worked as linker, carrier and part of the fluorophore. Benefiting from R₁₂K, the fluorescent probe is completely water soluble, membrane permeable and well biocompatible. It shows...

article

Photoluminescence Lifetime Imaging of Synthesized Proteins in Living Cells Using an Iridium–Alkyne Probe

Jinyu Wang, Jie Xue, Zihe Yan, Sichun Zhang, more

Angewandte Chemie International Edition > 56 > 47 > 14928 - 14932

Designing probes for real‐time imaging of dynamic processes in living cells is a continuous challenge. Herein, a novel near‐infrared (NIR) photoluminescence probe having a long lifetime was exploited for photoluminescence lifetime imaging (PLIM) using an iridium‐alkyne complex. This probe offers the benefits of deep‐red to NIR emission, a long Stokes shift, excellent cell penetration, low cytotoxicity,...

article

Photoluminescence Lifetime Imaging of Synthesized Proteins in Living Cells Using an Iridium–Alkyne Probe

Jinyu Wang, Jie Xue, Zihe Yan, Sichun Zhang, more

Angewandte Chemie > 129 > 47 > 15124 - 15128

article

Simultaneous imaging of newly synthesized proteins and lipids in single cell by TOF-SIMS

Linfeng Sheng, Lesi Cai, Jia Wang, Zhanping Li, more

International Journal of Mass Spectrometry > 2017 > 421 > C > 238-244

Cell growth and division are important processes for life. To understand the distribution and behaviors of the key molecules that dominate the cell growth and division still remains a challenge. Herein, we propose a strategy for visualization of newly synthesized proteins by TOF-SIMS coupled with metabolic incorporation of ¹⁵N labelled amino acids during the cell growth. Moreover, we simultaneously...

article

A Computationally Efficient Received Signal Strength Based Localization Algorithm in Closed-Form for Wireless Sensor Network

Xinrong Zhang, Weili Xiong, Baoguo Xu

Neural Processing Letters > 2017 > 46 > 3 > 1043-1057

Ranging error is known to degrade significantly the target node localization accuracy. This paper investigates the use of computationally efficient positioning solution of least square (LS) in closed-form, to reduce localization accuracy loss caused by ranging error. For range-based node localization, the LS solution based on least square criterion has been confirmed to exhibit capability of optimum...

article

A rapid screening platform for catalyst discovery in azide–alkyne cycloaddition by ICP-MS/MS

Qian He, Jia Wang, Yuxiang Mo, Chao Wei, more

Talanta > 2017 > 165 > C > 39-43

We developed a rapid high-throughput screening platform using a modified ICP-MS/MS system for monovalence metal ions catalysts discovery in azide–alkyne cycloaddition. Among the ten monovalence metal ions in the first row of periodic table containing Sc⁺, Ti⁺, V⁺, Cr⁺, Mn⁺, Fe⁺, Co⁺, Ni⁺, Cu⁺, and Zn⁺, five monovalence metal ions of Sc⁺, Co⁺, Ni⁺, Cu⁺ and Zn⁺ ions show relatively stronger catalytic...

article

Spatiotemporal fluorescence imaging of newly synthesized proteins in normal and cancerous cells with anticarcinogen modulation

Jinyu Wang, Linfeng Sheng, Hansen Zhao, Xinrong Zhang, more

Talanta > 2017 > 162 > C > 641-647

Some anticarcinogen could treat cancers through regulating the synthesis and degradation of proteins. Therefore, the rules of newly synthesized proteins would be used to evaluate the effect of anticarcinogen. In this study, we coupled noncanonical amino acid tagging with click reaction to label the newly synthesized proteins in normal cells and cancerous cells. We studied the influence of six different...

article

Graphene Oxide as a Novel Evenly Continuous Phase Matrix for TOF-SIMS

Lesi Cai, Linfeng Sheng, Mengchan Xia, Zhanping Li, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 3 > 399-408

Using matrix to enhance the molecular ion signals for biomolecule identification without loss of spatial resolution caused by matrix crystallization is a great challenge for the application of TOF-SIMS in real-world biological research. In this report, graphene oxide (GO) was used as a matrix for TOF-SIMS to improve the secondary ion yields of intact molecular ions ([M + H]⁺). Identifying and distinguishing...

chapter

Rotor position detection based on BEMF zero-crossing detection method with three-EMF force superposition

Xinrong Zhang, Huimin Gao, Chunyan Zeng

2016 13th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI) > 740 - 745

2016 13th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI)

Compared with the position sensor control, sensorless control avoids a lot of defects caused by the position sensor, at the same time makes the system more stability and stronger anti-interference performance, it has more advantages and meets control field's requirements better in the future, it has gradually become a hotspot in the brushless DC motor control field. The rotor position detection has...

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INFONA - science communication portal

Search results for: Xinrong Zhang

Deubiquitinase Ubp3 regulates ribophagy and deubiquitinates Smo1 for appressorium‐mediated infection by Magnaporthe oryzae

Controlling tractor‐semitrailer vehicles in automated highway systems: Adaptive robust and Lyapunov minimax approach

Similarly low risk of hepatocellular carcinoma after either spontaneous or nucleos(t)ide analogue‐induced hepatitis B surface antigen loss

Chemical profiling of Honghua Xiaoyao tablet and simultaneous determination of its quality markers by liquid chromatography–tandem mass spectrometry combined with chemometrics methods

Unhealthy lifestyle habits and physical inactivity among Asian patients with non‐alcoholic fatty liver disease

Simultaneous multicolour imaging using quantum dot structured illumination microscopy

A VEGFR2–MICA bispecific antibody activates tumor-infiltrating lymphocytes and exhibits potent anti-tumor efficacy in mice

CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy

Gold nanoparticles-enhanced ion-transmission mass spectrometry for highly sensitive detection of chemical warfare agent simulants

Ratiometric quantification of β2-microglobulin antigen in human serum based on elemental labeling strategy

Mass spectrometry imaging of intact cholesterol in a mouse esophagus tissue section and mouse zygotes using VUV laser desorption/ionization method

A cell-penetrating ratiometric probe for simultaneous measurement of lysosomal and cytosolic pH change

Photoluminescence Lifetime Imaging of Synthesized Proteins in Living Cells Using an Iridium–Alkyne Probe

Photoluminescence Lifetime Imaging of Synthesized Proteins in Living Cells Using an Iridium–Alkyne Probe

Simultaneous imaging of newly synthesized proteins and lipids in single cell by TOF-SIMS

A Computationally Efficient Received Signal Strength Based Localization Algorithm in Closed-Form for Wireless Sensor Network

A rapid screening platform for catalyst discovery in azide–alkyne cycloaddition by ICP-MS/MS

Spatiotemporal fluorescence imaging of newly synthesized proteins in normal and cancerous cells with anticarcinogen modulation

Graphene Oxide as a Novel Evenly Continuous Phase Matrix for TOF-SIMS

Rotor position detection based on BEMF zero-crossing detection method with three-EMF force superposition

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