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1. Endothelin-1 (ET-1) contracted canine cerebral artery in a concentration-dependent manner with an increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ), and at higher concentrations it produced a greater contraction with a smaller increase in [Ca 2+ ] i .2. Ca 2+ channel antagonist such as d-cis-diltiazem inhibited the tension...
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