Search results for: Christopher L. Hendrickson

Items from 1 to 20 out of 107 results

article

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Chad R. Weisbrod, Nathan K. Kaiser, John E. P. Syka, Lee Early, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 9 > 1787-1795

High resolution mass spectrometry is a key technology for in-depth protein characterization. High-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) enables high-level interrogation of intact proteins in the most detail to date. However, an appropriate complement of fragmentation technologies must be paired with FTMS to provide comprehensive sequence coverage, as well as...

article

Erratum to: Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Lidong He, Lissa C. Anderson, David R. Barnidge, David L. Murray, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 839-839

The online version of the original article can be found at http://dx.doi.org/10.1007/s13361-017-1602-6

article

Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Lidong He, Lissa C. Anderson, David R. Barnidge, David L. Murray, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 827-838

With the rapid growth of therapeutic monoclonal antibodies (mAbs), stringent quality control is needed to ensure clinical safety and efficacy. Monoclonal antibody primary sequence and post-translational modifications (PTM) are conventionally analyzed with labor-intensive, bottom-up tandem mass spectrometry (MS/MS), which is limited by incomplete peptide sequence coverage and introduction of artifacts...

article

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Christopher L. Hendrickson, John P. Quinn, Nathan K. Kaiser, Donald F. Smith, more

Journal of The American Society for Mass Spectrometry > 2015 > 26 > 9 > 1626-1632

We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front...

article

Controlled Ion Ejection from an External Trap for Extended m/z Range in FT-ICR Mass Spectrometry

Nathan K. Kaiser, Joshua J. Savory, Christopher L. Hendrickson

Journal of The American Society for Mass Spectrometry > 2014 > 25 > 6 > 943-949

An auxiliary rf waveform of the same amplitude and phase applied to all the rods of an ion accumulation multipole creates an m/z-dependent axial pseudo potential. Controlled decrease of the auxiliary rf amplitude releases ions from the accumulation multipole sequentially from high to low m/z. The slope of the auxiliary rf voltage ramp is adjusted so that ions of different m/z reach the center of the...

article

Laserspray and Matrix-Assisted Ionization Inlet Coupled to High-Field FT-ICR Mass Spectrometry for Peptide and Protein Analysis

Leonard Nyadong, Ellen D. Inutan, Xu Wang, Christopher L. Hendrickson, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 3 > 320-328

We present the first coupling of laser spray ionization inlet (LSII) and matrix assisted ionization inlet (MAII) to high-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for generation of electrospray-like ions to take advantage of increased sensitivity, mass range, and mass resolving power afforded by multiple charging. We apply the technique to top-down protein analysis...

article

Artifacts Induced by Selective Blanking of Time-Domain Data in Fourier Transform Mass Spectrometry

Feng Xian, Santosh G. Valeja, Steve C. Beu, Christopher L. Hendrickson, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 11 > 1722-1726

Fourier transform mass spectrometry (FTMS) of the isolated isotopic distribution for a highly charged biomolecule produces time-domain signal containing large amplitude signal “beats” separated by extended periods of much lower signal magnitude. Signal-to-noise ratio for data sampled between beats is low because of destructive interference of the signals induced by members of the isotopic distribution...

article

Elemental Composition Validation from Stored Waveform Inverse Fourier Transform (SWIFT) Isolation FT-ICR MS Isotopic Fine Structure

Brian M. Ruddy, Gregory T. Blakney, Ryan P. Rodgers, Christopher L. Hendrickson, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 10 > 1608-1611

Elemental composition assignment confidence in mass spectrometry is typically assessed by monoisotopic mass accuracy. For a given mass accuracy, resolution and detection of other isotopologues can further narrow the number of possible elemental compositions. However, such measurements require ultrahigh resolving power and high dynamic range, particularly for compounds containing low numbers of nitrogen...

article

Baseline correction of absorption-mode Fourier transform ion cyclotron resonance mass spectra

Feng Xian, Yuri E. Corilo, Christopher L. Hendrickson, Alan G. Marshall

International Journal of Mass Spectrometry > 2012 > 325-327 > Complete > 67-72

An absorption-mode Fourier transform ion cyclotron resonance (FT-ICR) mass spectrum exhibits two types of baseline distortion: a slow periodic oscillation even where no signal peaks are present, and additional distortion near signal peaks and proportional to signal magnitude. These distortions interfere with automated peak-picking, unless the baseline systematic variation is much less than baseline...

article

Erratum to: Fourier Transform Ion Cyclotron Resonance Mass Resolution and Dynamic Range Limits Calculated by Computer Modeling of Ion Cloud Motion

Gleb Vladimirov, Christopher L. Hendrickson, Greg T. Blakney, Alan G. Marshall, more

Journal of The American Society for Mass Spectrometry > 2012 > 23 > 2 > 385-385

article

Fourier Transform Ion Cyclotron Resonance Mass Resolution and Dynamic Range Limits Calculated by Computer Modeling of Ion Cloud Motion

Gleb Vladimirov, Christopher L. Hendrickson, Greg T. Blakney, Alan G. Marshall, more

Journal of The American Society for Mass Spectrometry > 2012 > 23 > 2 > 375-384

Particle-in-Cell (PIC) ion trajectory calculations provide the most realistic simulation of Fourier transform ion cyclotron resonance (FT-ICR) experiments by efficient and accurate calculation of the forces acting on each ion in an ensemble (cloud), including Coulomb interactions (space charge), the electric field of the ICR trap electrodes, image charges on the trap electrodes, the magnetic field,...

article

Relative Stability of Peptide Sequence Ions Generated by Tandem Mass Spectrometry

Benjamin J. Bythell, Christopher L. Hendrickson, Alan G. Marshall

Journal of The American Society for Mass Spectrometry > 2012 > 23 > 4 > 644-654

We report the use of unimolecular dissociation by infrared radiation for gaseous multiphoton energy transfer to determine relative activation energy (E_a,laser) for dissociation of peptide sequence ions. The sequence ions of interest are mass-isolated; the entire ion cloud is then irradiated with a continuous wave CO₂ laser, and the first order rate constant, k_d, is determined for each of a series...

article

Identification of phosphorylated human peptides by accurate mass measurement alone

Yuan Mao, Leonid Zamdborg, Neil L. Kelleher, Christopher L. Hendrickson, more

International Journal of Mass Spectrometry > 2011 > 308 > 2-3 > 357-361

At sufficiently high mass accuracy, it is possible to distinguish phosphorylated from unmodified peptides by mass measurement alone. We examine the feasibility of that idea, tested against a library of all possible in silico tryptic digest peptides from the human proteome database. The overlaps between in silico tryptic digest phosphopeptides generated from known phosphorylated proteins (1–12 sites)...

article

Unit Mass Baseline Resolution for an Intact 148 kDa Therapeutic Monoclonal Antibody by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Santosh G. Valeja, Nathan K. Kaiser, Feng Xian, Christopher L. Hendrickson, more

Analytical Chemistry > 2011 > 83 > 22 > 8391 - 8395

article

Valence Parity to Distinguish c′ and z ^• Ions from Electron Capture Dissociation/Electron Transfer Dissociation of Peptides: Effects of Isomers, Isobars, and Proteolysis Specificity

Yuan Mao, Jeremiah D. Tipton, Greg T. Blakney, Christopher L. Hendrickson, more

Analytical Chemistry > 2011 > 83 > 20 > 8024 - 8028

article

Predator data station: A fast data acquisition system for advanced FT-ICR MS experiments

Greg T. Blakney, Christopher L. Hendrickson, Alan G. Marshall

International Journal of Mass Spectrometry > 2011 > 306 > 2-3 > 246-252

Here, we present the Predator data station, a control system for FT-ICR mass spectrometers that champions speed and experimental flexibility while simultaneously providing stability, ease of use, and the ability to integrate more advanced hardware as it becomes available. The Predator is the first FT-ICR MS data station comprised solely of fast PCI, PXI, and yet faster PXI Express-based commercial...

article

Electrically Compensated Fourier Transform Ion Cyclotron Resonance Cell for Complex Mixture Mass Analysis

Nathan K. Kaiser, Joshua J. Savory, Amy M. McKenna, John P. Quinn, more

Analytical Chemistry > 2011 > 83 > 17 > 6907 - 6910

article

Coulombic shielding during ion cyclotron excitation in FT-ICR mass spectrometry

Brian M. Ruddy, Steven C. Beu, Nathan K. Kaiser, Christopher L. Hendrickson, more

International Journal of Mass Spectrometry > 2011 > 301 > 1-3 > 220-223

Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry relies upon linearity between the ion cyclotron excitation and the observed response. However, nonlinearities result from non-ideal applied electric and magnetic fields and Coulombic interactions. Here, we report nonlinear response at low excitation electric field magnitude due to Coulombic shielding. The measured ICR signal magnitude...

article

Petroleomics: advanced molecular probe for petroleum heavy ends

Chang S. Hsu, Christopher L. Hendrickson, Ryan P. Rodgers, Amy M. McKenna, more

Journal of Mass Spectrometry > 46 > 4 > 337 - 343

To look into complex mixtures of petroleum heavy ends at the molecular level, ultra high‐resolution mass spectrometry, i.e. resolving power > 50 000, is needed to resolve overlapping components for accurate determination of molecular composition of individual components. Recent progress in Fourier transform ion cyclotron resonance mass spectrometry (FT‐ICR MS) incorporated with soft ionization...

article

Atmospheric Pressure Laser-Induced Acoustic Desorption Chemical Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for the Analysis of Complex Mixtures

Leonard Nyadong, Amy M. McKenna, Christopher L. Hendrickson, Ryan P. Rodgers, more

Analytical Chemistry > 2011 > 83 > 5 > 1616 - 1623

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INFONA - science communication portal

Search results for: Christopher L. Hendrickson

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Erratum to: Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Controlled Ion Ejection from an External Trap for Extended m/z Range in FT-ICR Mass Spectrometry

Laserspray and Matrix-Assisted Ionization Inlet Coupled to High-Field FT-ICR Mass Spectrometry for Peptide and Protein Analysis

Artifacts Induced by Selective Blanking of Time-Domain Data in Fourier Transform Mass Spectrometry

Elemental Composition Validation from Stored Waveform Inverse Fourier Transform (SWIFT) Isolation FT-ICR MS Isotopic Fine Structure

Baseline correction of absorption-mode Fourier transform ion cyclotron resonance mass spectra

Erratum to: Fourier Transform Ion Cyclotron Resonance Mass Resolution and Dynamic Range Limits Calculated by Computer Modeling of Ion Cloud Motion

Fourier Transform Ion Cyclotron Resonance Mass Resolution and Dynamic Range Limits Calculated by Computer Modeling of Ion Cloud Motion

Relative Stability of Peptide Sequence Ions Generated by Tandem Mass Spectrometry

Identification of phosphorylated human peptides by accurate mass measurement alone

Unit Mass Baseline Resolution for an Intact 148 kDa Therapeutic Monoclonal Antibody by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Valence Parity to Distinguish c′ and z ^• Ions from Electron Capture Dissociation/Electron Transfer Dissociation of Peptides: Effects of Isomers, Isobars, and Proteolysis Specificity

Predator data station: A fast data acquisition system for advanced FT-ICR MS experiments

Electrically Compensated Fourier Transform Ion Cyclotron Resonance Cell for Complex Mixture Mass Analysis

Coulombic shielding during ion cyclotron excitation in FT-ICR mass spectrometry

Petroleomics: advanced molecular probe for petroleum heavy ends

Atmospheric Pressure Laser-Induced Acoustic Desorption Chemical Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for the Analysis of Complex Mixtures

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