Search results for: Sasmita Das

Items from 1 to 16 out of 16 results

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Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats

Haiyang Xu, Sasmita Das, Marc Sturgill, Colin Hodgkinson, more

Psychopharmacology > 2017 > 234 > 16 > 2475-2487

Rationale The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of breeding. Objective The objective of the present study is to compare cocaine preference,...

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The relationship of abdominal girth with blood pressure, blood sugar and lipid profile among cardiac patients

Sasmita Das, Nikee Minz, Mahesh C. Sahu

Journal of Taibah University Medical Sciences > 2017 > 12 > 2 > 178-182

This study aimed to characterize and identify the relationship of abdominal girth with blood pressure, blood sugar and lipid profile among cardiac patients.A total of 100 patients with diagnosed cardiac problems were recruited from the outpatient clinic of a multi-speciality hospital. For data collection, a self-administered questionnaire was used to gather information about patients' demographics...

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Synthesis of Pinacolylboronate-Substituted Stilbenes and their application to the synthesis of boron capped polyenes

Bhaskar C. Das, Sakkarapalayam M. Mahalingam, Sasmita Das, Narayan S. Hosmane, more

Journal of Organometallic Chemistry > 2015 > 798 > P1 > 51-59

A series of novel 4,4,5,5-tetramethyl-2-(4-substitutedstyrylphenyl)-1,3,2 dioxaborolane derivatives has been synthesized. 4-(4,4,5,5-tetramethyl-1,3,2-dioxaboratophenyl)-methyl triphenylphosphonium bromide (4) was treated with 3 equiv of tBuONa, various aldehydes in the presence of DMF, and stirred at room temperature 4–6 h to yield the corresponding boron containing stilbene derivatives 1a-n in 71–94%...

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Bacterial chromate reductase, a potential enzyme for bioremediation of hexavalent chromium: A review

Hrudayanath Thatoi, Sasmita Das, Jigni Mishra, Bhagwat Prasad Rath, more

Journal of Environmental Management > 2014 > 146 > C > 383-399

Hexavalent chromium is mobile, highly toxic and considered as a priority environmental pollutant. Chromate reductases, found in chromium resistant bacteria are known to catalyse the reduction of Cr(VI) to Cr(III) and have recently received particular attention for their potential use in bioremediation process. Different chromate reductases such as ChrR, YieF, NemA and LpDH, have been identified from...

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Optimization of extracellular chromate reductase production by Bacillus amyloliquefaciens (CSB 9) isolated from chromite mine environment

Bhagwat Prasad Rath, Sasmita Das, Pradeep Kumar Das Mohapatra, Hrudayanath Thatoi

Biocatalysis and Agricultural Biotechnology > 2014 > 3 > 3 > 35-41

Chromate reductase production by a bacterial isolate CSB 9 has been optimized to a high titer in the present investigation. The bacterium isolated previously from a chromium contaminated site and identified as Bacillus amyloliquefaciens following biochemical and 16S rRNA gene sequencing, was evaluated for chromate reductase production. Chromate reductase activity of B. amyloliquefaciens (CSB 9) was...

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Discovery of 3-[2-(Imidazo[1,2- b ]pyridazin-3-yl)ethynyl]-4-methyl- N -{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Wei-Sheng Huang, Chester A. Metcalf, Raji Sundaramoorthi, Yihan Wang, more

Journal of Medicinal Chemistry > 2010 > 53 > 12 > 4701 - 4719

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5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-α and mTOR for the treatment of breast cancer

Nan Zhang, Semiramis Ayral-Kaloustian, James T. Anderson, Thai Nguyen, more

Bioorganic & Medicinal Chemistry Letters > 2010 > 20 > 12 > 3526-3529

A series of 5-ureidobenzofuran-3-one indoles as potent inhibitors of PI3Kα and mTOR has been developed. The best potency in cells was obtained when the urea group was extended to a 4-[2-(dimethylamino)ethyl]methylamino amidophenyl group. A 7-fluoro group on the indole ring also enhanced cellular potency. Compound 18i, incorporating the optimal functional groups, showed high potency in cellular lines...

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9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation

Wei-Sheng Huang, Xiaotian Zhu, Yihan Wang, Mohammad Azam, more

Journal of Medicinal Chemistry > 2009 > 52 > 15 > 4743 - 4756

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Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors

Yihan Wang, William C. Shakespeare, Wei-Sheng Huang, Raji Sundaramoorthi, more

Bioorganic & Medicinal Chemistry Letters > 2008 > 18 > 17 > 4907-4912

Novel N⁹-arenethenyl purines, optimized potent dual Src/Abl tyrosine kinase inhibitors, are described. The key structural feature is a trans vinyl linkage at N⁹ on the purine core which projects hydrophobic substituents into the selectivity pocket at the rear of the ATP site. Their synthesis was achieved through a Horner–Wadsworth–Emmons reaction of N⁹-phosphorylmethylpurines and substituted benzaldehydes...

article

Facile synthesis of 9-(arenethenyl)purines via Heck reaction of 9-vinylpurines and aryl halides

Wei-Sheng Huang, Yihan Wang, Raji Sundaramoorthi, R. Mathew Thomas, more

Tetrahedron Letters > 2007 > 48 > 41 > 7388-7391

The first example of a Heck reaction with 9-vinylpurines and aryl halides is described. It gives exclusively E-9-(arenethenyl)purines in high yields. Subsequent hydrogenation furnishes 9-(arenethyl)purines quantitatively.

article

Synthesis and crystal structure of 4-amino-3-fluorophenylboronic acid

Sasmita Das, Vladimir L. Alexeev, Anjal C. Sharma, Steven J. Geib, more

Tetrahedron Letters > 2003 > 44 > 42 > 7719 - 7722

4-Amino-3-fluorophenyl boronic acid has been synthesized from 4-bromo-2-fluoroaniline by protecting the amine group and then carrying out a lithium-bromine exchange, followed by addition of trimethyl borate and then acidic hydrolysis. We obtained a 47% yield. We also measured the X-ray crystal structure. This derivative has a relatively low boronic acid pK _a value of 7.8 when acetylated or...

article

High Ionic Strength Glucose-Sensing Photonic Crystal

Vladimir L. Alexeev, Anjal C. Sharma, Alexander V. Goponenko, Sasmita Das, more

Analytical Chemistry > 2003 > 75 > 10 > 2316 - 2323

article

NaIO ₄ -DMF: a novel reagent for the oxidation of organic halides to carbonyl compounds

Sasmita Das, A.K. Panigrahi, Golak C. Maikap

Tetrahedron Letters > 2003 > 44 > 7 > 1375 - 1377

NaIO ₄ -DMF oxidises various primary and secondary halides to the corresponding aldehydes and ketones under mild conditions (150 ^o C/40-60 min) in high yields (70-90%).

article

Rhodium-catalyzed 1,4-addition reactions of diboron reagents to electron deficient olefins

George W. Kabalka, Bhaskar C. Das, Sasmita Das

Tetrahedron Letters > 2002 > 43 > 13 > 2323 - 2325

The 1,4-addition of bis(pinacolato)diboron and bis(neopentyl glycolato)diboron to α,β-unsaturated ketones, esters, nitriles, and aldehydes was developed using a rhodium catalyst.

article

Synthesis of novel boron containing unnatural cyclic amino acids as potential therapeutic agents

George W Kabalka, Bhaskar C Das, Sasmita Das

Tetrahedron Letters > 2001 > 42 > 41 > 7145-7146

Two boronated α-amino acids, 1-amino-3-boronocyclopentanecarboxylic acid and 1-amino-3-boronocycloheptanecarboxylic acid were prepared. The key step in the syntheses was the 1,4-boration of the α,β-unsaturated cyclic ketones using the bis-pinacolatodiboron ester to generate the boronated ketones which were then converted to the corresponding amino acids.

article

Synthesis of a water soluble boron neutron capture therapy agent: 1-amino-3-[2-(7-{3-[2-(2-hydroxymethyl-ethoxy)-1-(2-hydroxy-1-hydroxymethyl- ethoxymethyl)ethoxy]propyl}-1,7-di-carba-closo-dodecaboran-1-yl)ethyl]cyclob utanecarboxylic acid

Bhaskar C. Das, George W. Kabalka, Rajiv R. Srivastava, Weiliang Bao, more

Journal of Organometallic Chemistry > 2000 > 614-615 > 255 - 261

A water soluble boronated amino acid containing a cascade polyol, 1-amino-3-[2-(7-{3-[2-(2-hydroxymethyl-ethoxy)-1-(2-hydroxy-1-hydroxymethyl- ethoxymethyl)ethoxy]propyl}-1,7-di-carba-closo-dodecaboran-1-yl)ethyl]cyclob utanecarboxylic acid, has been developed. The key step in the synthesis is the alkylation of 3-[2-(1,7-dicarba-closo-dodecarboran-1-yl)ethyl]cyclobutanone hemithioketal with toluene-4-sulfonic...

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