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The wide variety of enzymatic pathways that can benefit from enzyme scaffolding is astronomical. While enzyme co‐localization based on protein, DNA, and RNA scaffolds has been reported, we still lack scaffolds that offer well‐defined and uniform three‐dimensional structures for enzyme organization. Here we reported a new approach for protein co‐localization using naturally occurring protein nanocages...
Methanol:coenzyme M methyltransferase is an enzyme complex composed of three subunits, MtaA, MtaB, and MtaC, found in methanogenic archaea and is needed for their growth on methanol ultimately producing methane. MtaABC catalyzes the energetically favorable methyl transfer from methanol to coenzyme M to form methyl coenzyme M. Here we demonstrate that this important reaction for possible production...
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