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Interactions of hydrogen sulfide (HS−/H2S), a reducing signaling species, with superoxide dimutases (SOD) are poorly understood. We applied low-T EPR spectroscopy to examine the effects of HS−/H2S and superoxide radical anion (O2·−) on metallocenters of FeSOD, MnSOD, and CuZnSOD. HS−/H2S did not affect FeSOD, whereas active centers of MnSOD and CuZnSOD were open to this agent. Cu2+ was reduced to...
H 2 S was shown as an uterine relaxant. However, the signaling pathways, including ion channels regulated by H 2 S mediating relaxation in uterus are still unknown. The effects on contractility in response to sodium sulphide Na 2 S were examined on myometrial strips from virgin Wistar rats. Our results showed that Na 2 S induces concentration-dependent relaxations affecting...
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