Search results for: Jan Swakoń

Items from 1 to 16 out of 16 results

article

Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model - a proof of concept

Martyna Durak-Kozica, Ewa Stępień, Jan Swakoń, Paweł Moskal

Bio-Algorithms and Med-Systems > 2023 > Vol. 19, no. 1 > 31--34

Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model - spheroids) and the secretion of extracellular vesicles (EVs) and their cargo. The use of a modern method of creating spheroids...

article

Practice Patterns Analysis of Ocular Proton Therapy Centers: The International OPTIC Survey

Jan Hrbacek, Kavita K. Mishra, Andrzej Kacperek, Remi Dendale, more

International Journal of Radiation Oncology*Biology*Physics > 2016 > 95 > 1 > 336-343

To assess the planning, treatment, and follow-up strategies worldwide in dedicated proton therapy ocular programs.Ten centers from 7 countries completed a questionnaire survey with 109 queries on the eye treatment planning system (TPS), hardware/software equipment, image acquisition/registration, patient positioning, eye surveillance, beam delivery, quality assurance (QA), clinical management, and...

article

Improved proton stopping power ratio estimation for a deformable 3D dosimeter using Dual Energy CT

V.T. Taasti, Ellen Marie Høye, David Christoffer Hansen, Ludvig Paul Muren, more

Radiotherapy and Oncology > 2016 > 118 > S1 > S99-S100

article

Studies of scintillator response to 60 MeV protons in a proton beam imaging system

Marzena Rydygier, Gabriela Mierzwińska, Anna Czaderna, Jan Swakoń, more

Nukleonika > 2015 > 60 > 3 > 683-687

A Proton Beam Imaging System (ProBImS) is under development at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN). The ProBImS will be used to optimize beam delivery at IFJ PAN proton therapy facilities, delivering two-dimensional distributions of beam profiles. The system consists of a scintillator, optical tract and a sensitive CCD camera which digitally records the light emitted...

article

Application of the micronucleus assay performed by different scorers in case of large-scale radiation accidents

Kamila Rawojć, Dorota M. Tarnawska, Justyna U. Miszczyk, Jan Swakoń, more

Nukleonika > 2015 > 60 > 3 > 643-649

Mass casualty scenarios of radiation exposure require high throughput biological dosimetry techniques for population triage, in order to rapidly identify individuals, who require clinical treatment. Accurate dose estimates can be made by biological dosimetry, to predict the acute radiation syndrome (ARS) within days after a radiation accident or a malicious act involving radiation. Timely information...

article

Application of alanine dosimetry in dose assessment for ocular melanoma patients undergoing proton radiotherapy – preliminary results

Gabriela Mierzwińska, Magdalena Kłodowska, Barbara Michalec, Anna Pędracka, more

Nukleonika > 2015 > 60 > 3 > 609-613

Basing on alanine solid state/electron paramagnetic resonance (EPR) dosimetry, a supplementary method of cumulatively recording the therapeutic dose received by ocular cancer patients undergoing fractionated proton radiotherapy is proposed. By applying alanine dosimetry during the delivery of consecutive fractions, the dose received within each fraction can be read out by EPR spectrometry and a final...

article

Response of human lymphocytes to proton radiation of 60MeV compared to 250kV X-rays by the cytokinesis-block micronucleus assay

Justyna Miszczyk, Kamila Rawojć, Agnieszka Panek, Jan Swakoń, more

Radiotherapy and Oncology > 2015 > 115 > 1 > 128-134

Particle radiotherapy such as protons provides a new promising treatment modality to cancer. However, studies on its efficacy and risks are relatively sparse. Using the cytokinesis-blocked micronucleus assay, we characterized response of human peripheral blood lymphocytes, obtained from health donors irradiated in vitro in the dose range: 0–4. 0Gy, to therapeutic proton radiation of 60MeV from AIC-144...

article

Relative biological effectiveness of the 60-MeV therapeutic proton beam at the Institute of Nuclear Physics (IFJ PAN) in Kraków, Poland

Dorota Słonina, Beata Biesaga, Jan Swakoń, Damian Kabat, more

Radiation and Environmental Biophysics > 2014 > 53 > 4 > 745-754

The aim of the study was to determine the relative biological effectiveness (RBE) of a 60-MeV proton radiotherapy beam at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN) in Kraków, the first one to operate in Poland. RBE was assessed at the surviving fractions (SFs) of 0.01, 0.1, and 0.37, for normal human fibroblasts from three cancer patients. The cells were irradiated near...

article

Free radicals properties of gamma-irradiated penicillin-derived antibiotics: piperacillin, ampicillin, and crystalline penicillin

Sławomir Wilczyński, Barbara Pilawa, Robert Koprowski, Zygmunt Wróbel, more

Radiation and Environmental Biophysics > 2014 > 53 > 1 > 203-210

The aim of this work was to determine the concentrations and properties of free radicals in piperacillin, ampicillin, and crystalline penicillin after gamma irradiation. The radicals were studied by electron paramagnetic resonance (EPR) spectroscopy using an X-band spectrometer (9.3 GHz). Gamma irradiation was performed at a dose of 25 kGy. One- and two-exponential functions were fitted to the experimental...

article

Metastasis inhibition after proton beam, β- and γ-irradiation of melanoma growing in the hamster eye

Bożena Romanowska-Dixon, Martyna Elas, Jan Swakoń, Urszula Sowa, more

Acta Biochimica Polonica > 2013 > 60 > 3 > 307-311

Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development...

article

EPR studies of free radicals decay and survival in gamma irradiated aminoglycoside antibiotics: sisomicin, tobramycin and paromomycin

Sławomir Wilczyński, Barbara Pilawa, Robert Koprowski, Zygmunt Wróbel, more

European Journal of Pharmaceutical Sciences > 2012 > 45 > 3 > 251-262

Radiation sterilization technology is more actively used now that any time because of its many advantages. Gamma radiation has high penetrating power, relatively low chemical reactivity and causes small temperature rise. But on the other hand radiosterilization can lead to radiolytic products appearing, in example free radicals.Free radicals in radiative sterilized sisomicin, tobramycin and paromomycin...

article

Proton radiotherapy facility for ocular tumors at the IFJ PAN in Kraków Poland

Barbara Michalec, Jan Swakoń, Urszula Sowa, Marta Ptaszkiewicz, more

Applied Radiation and Isotopes > 2010 > 68 > 4-5 > 738-742

The proton radiotherapy facility for the eye melanoma treatment is under development at the Henryk Niewodniczański Institute of Nuclear Physics Polish Academy of Sciences (IFJ PAN) in Krakow. The facility uses protons, accelerated by the AIC-144 isochronous cyclotron up to the energy of 60MeV. The infrastructure and all necessary equipment have been already installed. The paper describes the present...

article

Radioprotectors from pyrodextrins

Oskar Michalski, Ewa Bidzińska, Michał Borowski, Krystyna Dyrek, more

Chinese Science Bulletin > 2010 > 55 > 31 > 3556-3561

Cornstarch heated in the range of 230–280°C depolymerized into pyrodextrins characterized by two-component EPR signals of relatively stable free radicals. These thermally generated radicals could serve as efficient scavengers for free radicals generated from pyrodextrins with the 200 Gy dose of γ-radiation. The most efficient traps/scavengers were produced from cornstarch at 250–280°C. IR data indicated...

chapter

Optimization of beam scattering system for IFJ PAN proton radiotherapy facility by Monte Carlo simulations

Joanna Dabrowska, Pawel Olko, Urszula Sowa, Jan Swakon

2008 IEEE Nuclear Science Symposium Conference Record > 1073 - 1076

2008 IEEE Nuclear Science Symposium and Medical Imaging conference (2008 NSS/MIC)

The work is aimed at optimizing the 60 MeV proton beam spreading system at the IFJ PAN radiotherapy facility for the treatment of ocular melanoma tumors. Single scattering foil and double scattering foil systems have been investigated by Monte Carlo simulations. In the case of the single scattering foil system dose distributions were uniform to within ± 1 % over a 4-cm-diameter region, whereas in...

chapter

Radiation exposure at the proton eye therapy facility at IFJ in Kraków

Tomasz Horwacik, Jan Swakon, Liliana Stolarczyk, Katarzyna Zbroja, more

2008 IEEE Nuclear Science Symposium Conference Record > 1093 - 1096

2008 IEEE Nuclear Science Symposium and Medical Imaging conference (2008 NSS/MIC)

The proton radiotherapy facility for the treatment of eye tumors is under development at the Institute of Nuclear Physics (IFJ) in Kraków. The optical line installed at the treatment room is applied to form and monitor the 60 MeV proton beam provided by the AIC-144 isochronous cyclotron. Typical proton dose rates measured at the isocentre varied between 0.01 and 0.5 Gy/s. The intensities of the secondary...

article

Estimation of thermal neutron absorption cross-section from K, U and Th concentrations for Miocene rocks from the Carpathian Piedmont in Poland using artificial neural networks

Jerzy Loskiewicz, Jan Swakoń, Krystyna Kulczykowska

Applied Radiation and Isotopes > 2000 > 52 > 6 > 1459-1465

The radiometric K, U and Th concentrations and neutron absorption cross-section Σ _a of rock samples obtained from coring are analysed. The cores are from wellbores located in the Sucha-Jordanow region (Carpathian Mountains) and from gas producing Miocene formations in the Carpathian foothills. Correlation coefficients between the neutron absorption cross-section (Σ _a ) and K, U and...

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