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Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory member of the serpin family of protease inhibitors that influences multiple cellular functions including adhesion, migration, and invasion in tumour malignancy. In this paper, we describe a computational model of the effects of exogenous maspin on cellular proliferation, migration and invasion. To date, the whole cellular mechanisms of...
This paper presents a novel method of chemotherapy drug scheduling for cancer treatment using feedback control and genetic algorithm (GA). The main aim of chemotherapy treatment is to eradicate the tumour, if possible, or to reduce the tumour size to a minimum level with minimum toxic side effects. A feedback control method is developed in order to maintain a predefined level of drug concentration...
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