Search results for: Jian Chen

Items from 1 to 20 out of 3,531 results

article

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Shaowen Xie, Feiyan Zhan, Jingjie Zhu, Yuan Sun, more

Angewandte Chemie > 135 > 13 > n/a - n/a

Hydrophobic tagging (HyT) is a potential therapeutic strategy for targeted protein degradation (TPD). Norbornene was discovered as an unprecedented hydrophobic tag in this study and was used to degrade the anaplastic lymphoma kinase (ALK) fusion protein by linking it to ALK inhibitors. The most promising degrader, Hyt‐9, potently reduced ALK levels through Hsp70 and the ubiquitin−proteasome system...

article

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Shaowen Xie, Feiyan Zhan, Jingjie Zhu, Yuan Sun, more

Angewandte Chemie International Edition > 62 > 13 > n/a - n/a

article

Fast and Durable Alkaline Hydrogen Oxidation Reaction at the Electron‐Deficient Ruthenium–Ruthenium Oxide Interface

Xiaoyu (Baohua) Zhang, Lixue Xia, Guoqiang Zhao, Bingxing Zhang, more

Advanced Materials > 35 > 9 > n/a - n/a

The slow hydrogen oxidation reaction (HOR) kinetics under alkaline conditions remain a critical challenge for the practical application of alkaline exchange membrane fuel cells. Herein, Ru/RuO₂ in‐plane heterostructures are designed with abundant active Ru–RuO₂ interface domains as efficient electrocatalysts for the HOR in alkaline media. The experimental and theoretical results demonstrate that interfacial...

article

Achieving Near‐unity Photoluminescence Quantum Yields in Organic‐Inorganic Hybrid Antimony (III) Chlorides with the [SbCl₅] Geometry

Chen Sun, Zeyu Deng, Zhiyuan Li, Zhongwei Chen, more

Angewandte Chemie International Edition > 62 > 10 > n/a - n/a

Hybrid organic–inorganic antimony halides have attracted increasing attention due to the non‐toxicity, stability, and high photoluminescence quantum yield (PLQY). To shed light on the structural factors that contribute to the high PLQY, five pairs of antimony halides with general formula A₂SbCl₅ and A₂Sb₂Cl₈ are synthesized via two distinct methods and characterized. The A₂SbCl₅ type adopts square...

article

Achieving Near‐unity Photoluminescence Quantum Yields in Organic‐Inorganic Hybrid Antimony (III) Chlorides with the [SbCl₅] Geometry

Chen Sun, Zeyu Deng, Zhiyuan Li, Zhongwei Chen, more

Angewandte Chemie > 135 > 10 > n/a - n/a

article

Fast, Multi‐Bit, and Vis‐Infrared Broadband Nonvolatile Optoelectronic Memory with MoS₂/2D‐Perovskite Van der Waals Heterojunction

Haojie Lai, Zhengli Lu, Yueheng Lu, Xuanchun Yao, more

Advanced Materials > 35 > 6 > n/a - n/a

Nonvolatile optoelectronic memory (NVOM) integrating the functions of optical sensing and long‐term memory can efficiently process and store a large amount of visual scene information, which has become the core requirement of multiple intelligence scenarios. However, realizing NVOM with vis‐infrared broadband response is still challenging. Herein, the room temperature vis‐infrared broadband NVOM based...

article

Evaluation index system for the implementation of extended producer responsibility system: Chinese beverage paper‐based composite packaging manufacturers

Jian Chen, Xianzhong Mu, Chuang Tu, Guangwen Hu

Packaging Technology and Science > 36 > 3 > 195 - 210

Paper‐based composite packages, which have been widely used for beverage in modern daily life, are featured of nutrition preservation and convenience. However, it is also causing environmental problems in urban areas because of the low recycling rate. The introduction of extended producer responsibility (EPR) is helpful to improving the recycling rate of beverage paper‐based composite packaging by...

article

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

Qi‐Xin Wen, Biao Luo, Xiao‐Yong Xie, Gui‐Feng Zhou, more

Traffic > 24 > 1 > 20 - 33

AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the pathogenesis of Alzheimer disease (AD) by generating the toxic β‐amyloid peptide (Aβ). We found that knockdown or overexpression of AP2S1 decreased or increased...

article

Facile Synthesis of Chiral α‐Hydroxy Ketones by a Ni‐Catalyzed Multicomponent Hydrometallation–CO Insertion–Enantioconvergent Alkylation Cascade

Jian Chen, Gao Deng, You Wang, Shaolin Zhu

Chinese Journal of Chemistry > 41 > 3 > 294 - 300

NiH‐catalyzed multicomponent reductive hydrofunctionalization of alkenes is an attractive but poorly explored approach to rapidly increasing molecular complexity. In this process, the selective generation of the desired product can be challenging. Herein, we report that a highly chemo‐, regio‐ and enantioselective reductive hydrocarbonylation of alkenes has been achieved using a chloroformate ester...

article

Light‐Responsive Polyblend Films with Reconfigurable Surface Micropatterns as Rewritable Information Storage Media

Jian Chen, Xiaoyu Yang, Jie Chen, Umair Azhar, more

Chinese Journal of Chemistry > 41 > 3 > 273 - 279

Stimulus‐sensitive surfaces with tunable morphologies exhibit a wide range of applications in the fields of surface science and engineering. Herein, a cost‐effective yet practical strategy is proposed to fabricate photo‐sensitive patterning surface on film/substrate wrinkle system based on an azo‐containing polyblend. By manipulating the stress field of the bilayer system globally and/or locally upon...

article

Self‐supervised domain adaptation for cross‐domain fault diagnosis

Weikai Lu, Haoyi Fan, Kun Zeng, Zuoyong Li, more

International Journal of Intelligent Systems > 37 > 12 > 10903 - 10923

Unsupervised domain adaptation‐based fault diagnosis methods have been extensively studied due to their powerful knowledge transferability under different working conditions. Despite their encouraging performance, most of them cannot sufficiently account for the temporal dimension of the vibration signal, resulting in incomplete feature information used in the domain alignment procedure. To alleviate...

article

Restoration of appearance for women after aesthetic eyelash transplantation using a novel eyelash resection technique

Jian Chen, Bei Cui, Zhexiang Fan, Jiajing Yin, more

Journal of Cosmetic Dermatology > 21 > 11 > 5859 - 5863

Background Hair transplantation based on the follicular unit extraction provides a new opportunity to improve the appearance of patients with congenital sparse eyelashes. However, disparity between transplanted grafts and original eyelashes and the physiological characteristics of upper eyelid skin cause difficulties with this technique and result in low satisfaction. Removal of unsatisfactory eyelashes...

article

Superhydrophobic Coating Deposited on Foamed Concrete with Super‐Robust Mechanical and Self‐Repairing Properties

Zhenzhen Lu, Jian Chen, Xiaoqing Zhang

physica status solidi (a) > 219 > 24 > n/a - n/a

A super‐robust and self‐repairing superhydrophobic (SRS) coating is prepared on foamed concrete via a facile and low‐cost method using hydrophobic silica nanoparticles as building blocks connected by silicone sealant and epoxy resin for constructing micro‐/nanostructures. The surface wettability, morphology, and chemical composition are tested by a contact angle (CA) goniometer, scanning electron...

article

Preparation of MOF‐Zn@ZnO composite and its properties in SBR

Zhiqiang Lei, Yankang Wu, Liping Tang, Jian Chen

Polymer Composites > 43 > 12 > 8749 - 8760

The synthesis and application of metal–organic skeleton materials (MOFs) have attracted much attention in recent years due to their special structures and properties. In order to expand the application field of MOFs materials, this paper designed experiments to explore the application prospect of MOFs materials in the field of rubber. In this study, zinc acetate dihydrate was used as the central metal...

article

Equipment for in situ measurement of machining defects of large aperture optical elements

Guipeng Tie, Haifeng Zhou, Feng Shi, Jian Chen, more

International Journal of Applied Glass Science > 14 > 1 > 3 - 6

A set of in situ measurement equipment of large aperture strong light element based on the principle of laser scattering is established. The size and distribution of defects (damage points) can be judged by the laser scattering signal. The maximum scanning range is 700 mm*1000 mm. The type and size of defects are directly obtained by scanning the quartz sample with a diameter of 100 mm. The types...

article

Synchronous in situ follicular neoplasia with MALT lymphoma and intramucosal adenocarcinoma in the stomach: A case report

Jian Chen Fang, Xue Qin Zeng, Lu Zhong

Journal of Digestive Diseases > 23 > 8-9 > 546 - 548

article

A PadR family transcriptional repressor controls transcription of a trivalent metalloid resistance operon of Azospirillum halopraeferens strain Au 4

Jun Zhang, Yi‐Fei Wu, Shi‐Tong Tang, Jian Chen, more

Environmental Microbiology > 24 > 11 > 5139 - 5150

Methylarsenite [MAs(III)] is a highly toxic arsenical produced by some microbes as an antibiotic. In this study, we demonstrate that a PadR family transcriptional regulator, PadR_ars, from Azospirillum halopraeferens strain Au 4 directly binds to the promoter region of the arsenic resistance (ars) operon (consisting of padR_ars, arsV, and arsW) and represses transcription of arsV and arsW genes involved...

article

Non‐Darcian flow toward an injection well fully penetrating a leaky confined aquifer with clogging‐induced permeability reduction

Jiong Li, Ming‐Guang Li, Hongbin Zhan, Jin‐Jian Chen, more

International Journal for Numerical and Analytical Methods in Geomechanics > 46 > 17 > 3217 - 3235

Managed aquifer recharge (MAR) using aquifer injection wells is generally developed with the validity of Darcy's law and assumption of a constant hydraulic conductivity, hence ignoring the non‐Darcian nature of groundwater flow and the spatiotemporal permeability reduction owing to well and aquifer clogging. In this study, an Izbash's law‐based analytical model is proposed for constant‐rate recharge...

article

Remnant tensile and creep properties of aluminized AISI 321 austenite stainless steel under prior creep–fatigue interaction

Huitao Chen, Wei Li, Wei Chen, Libo Zhou, more

Fatigue & Fracture of Engineering Materials & Structures > 45 > 12 > 3746 - 3763

Aluminized AISI 321 steels applied as heat exchange tube are generally subjected to creep–fatigue (C‐F) exposure during service. Remaining tensile and creep performance of this steel at 620°C were therefore studied under prior C‐F deformation. Results revealed that residual properties exhibit an initial increase and followed degradation with rising lifetime fraction of prior C‐F. The tensile strength...

article

In situ growth of ZnO on carbon nanospheres and its properties in natural rubber

Zhiqiang Lei, Yankang Wu, Liping Tang, Jian Chen

Polymer Composites > 43 > 11 > 8181 - 8191

Carbon Nanospheres (CNs) are nano‐carbon materials. In order to expand their application fields, this study applies them to rubber fillers. In this study, CNs were prepared by vapor deposition method in a high temperature tube furnace. After acidification of CNs, ZnO was grown in situ on the surface of CNs. CNs@ZnO/NR composite was prepared by traditional mechanical blending method. The experimental...

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INFONA - science communication portal

Search results for: Jian Chen

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Fast and Durable Alkaline Hydrogen Oxidation Reaction at the Electron‐Deficient Ruthenium–Ruthenium Oxide Interface

Achieving Near‐unity Photoluminescence Quantum Yields in Organic‐Inorganic Hybrid Antimony (III) Chlorides with the [SbCl₅] Geometry

Achieving Near‐unity Photoluminescence Quantum Yields in Organic‐Inorganic Hybrid Antimony (III) Chlorides with the [SbCl₅] Geometry

Fast, Multi‐Bit, and Vis‐Infrared Broadband Nonvolatile Optoelectronic Memory with MoS₂/2D‐Perovskite Van der Waals Heterojunction

Evaluation index system for the implementation of extended producer responsibility system: Chinese beverage paper‐based composite packaging manufacturers

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

Facile Synthesis of Chiral α‐Hydroxy Ketones by a Ni‐Catalyzed Multicomponent Hydrometallation–CO Insertion–Enantioconvergent Alkylation Cascade

Light‐Responsive Polyblend Films with Reconfigurable Surface Micropatterns as Rewritable Information Storage Media

Self‐supervised domain adaptation for cross‐domain fault diagnosis

Restoration of appearance for women after aesthetic eyelash transplantation using a novel eyelash resection technique

Superhydrophobic Coating Deposited on Foamed Concrete with Super‐Robust Mechanical and Self‐Repairing Properties

Preparation of MOF‐Zn@ZnO composite and its properties in SBR

Equipment for in situ measurement of machining defects of large aperture optical elements

Synchronous in situ follicular neoplasia with MALT lymphoma and intramucosal adenocarcinoma in the stomach: A case report

A PadR family transcriptional repressor controls transcription of a trivalent metalloid resistance operon of Azospirillum halopraeferens strain Au 4

Non‐Darcian flow toward an injection well fully penetrating a leaky confined aquifer with clogging‐induced permeability reduction

Remnant tensile and creep properties of aluminized AISI 321 austenite stainless steel under prior creep–fatigue interaction

In situ growth of ZnO on carbon nanospheres and its properties in natural rubber

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