Search results for: Xiaolei Tang

Items from 1 to 20 out of 27 results

article

Beta‐mannosidosis presenting predominantly with recurrent pulmonary infections, hemorrhage, and cystic lesions

Ruxuan He, Jinrong Liu, Hui Xu, Xiaolei Tang, more

Pediatric Pulmonology > 58 > 4 > 1272 - 1274

article

Case report of a pediatric Chinese cystic fibrosis patient with the c.1521_1523delCTT/c.3874‐4522A>G genotype

Yanyan Su, Yu Tang, Xiaolei Tang, Yuelin Shen

Pediatric Pulmonology > 58 > 2 > 556 - 558

This report describes a case of an 11‐year‐old Chinese boy with cystic fibrosis (CF) bearing the c.1521_1523delCTT/c.3874‐4522A>G genotype, an extremely rare CF genotype in the Chinese population. Notably, the deep intron mutation c.3874‐4522A>G, which has mainly been reported in patients with phenotypically mild CF, is identified here for the first time in a Chinese patient with severe CF....

article

Radiofrequency catheter ablation improves long‐term prognosis and cardiac function of the patients with tachyarrhythmia‐induced cardiomyopathy

Hongxiang Zhang, Dasheng Lu, Xiaolei Tang

International Journal of Clinical Practice > 75 > 6 > n/a - n/a

article

Pseudo‐Bartter syndrome in Chinese children with cystic fibrosis: Clinical features and genotypic findings

Yuelin Shen, Xiaolei Tang, Jinrong Liu, Huiming Li, more

Pediatric Pulmonology > 55 > 11 > 3021 - 3029

Objectives To characterize the clinical and genotypic features of cystic fibrosis‐associated pseudo‐Bartter syndrome (CF‐PBS) in Chinese children. Methods We recruited and characterized the clinical manifestations of 12 Chinese children with CF‐PBS. Sweat test, blood and urinary analysis, sputum culture, chest and sinus computed tomography, and abdominal ultrasonography were obtained. Whole‐exome...

article

Bronchoalveolar lavage T cell cytokine profiles and their association with lung function in children with Mycoplasma pneumoniae ‐associated bronchiolitis obliterans

Weihan Xu, Haiming Yang, Hui Liu, Xiaolei Tang, more

Pediatric Pulmonology > 55 > 8 > 2033 - 2040

Background Mycoplasma pneumoniae (M. pneumoniae) infection may progress to bronchiolitis obliterans (BO), with an underlying chronic inflammatory process. The aim of this study was to investigate the cytokine profiles in pulmonary T‐lymphocytes and their associations with lung function in patients with BO following M. pneumoniae infection. Methods Bronchoalveolar lavage (BAL) samples were obtained...

article

Cobalamin C deficiency presenting with diffuse alveolar hemorrhage and pulmonary microangiopathy

Jinrong Liu, Xiaolei Tang, Chunju Zhou, Hui Xu, more

Pediatric Pulmonology > 55 > 6 > 1481 - 1486

Objective Combined methylmalonic acidemia and homocysteinemia is a genetically heterogeneous disorder of cobalamin (cbl; vitamin B12) metabolism, which consists of five subtypes including cblC, cblD, cblF, cblJ, and cblX deficiencies. The purpose of this study is to summarize new clinical features mainly diffuse alveolar hemorrhage (DAH) in cblC deficiency. Methods We made a retrospective analysis...

article

Transdermal permeation effect of collagen hydrolysates of deer sinew on mouse skin, ex vitro, and antioxidant activity, increased type I collagen secretion of percutaneous proteins in NIH/3T3 cells

He Zhang, Daian Pan, Ying Dong, Wenjie Su, more

Journal of Cosmetic Dermatology > 19 > 2 > 519 - 528

Background The collagen hydrolysates as a cosmetic material have already been wide application. At present, few studies concern with transdermal behavior of collagen hydrolysates in vitro. Objective Deer sinew contains rich collagen with a content of 82.12%. Thus, this article mainly studies the transdermal effect of collagen hydrolysates of deer sinew (DSCH) on mouse skin, ex vitro, and to explore...

article

Effect of Leading-Edge Optimization on the Loss Characteristics in a Low-Pressure Turbine Linear Cascade

Tao Cui, Songtao Wang, Xiaolei Tang, Fengbo Wen, more

Journal of Thermal Science > 2019 > 28 > 5 > 886-904

This paper presents a numerical study on the aerodynamics loss reduction characteristics after the leading-edge (LE) optimization in a low-pressure turbine linear cascade. The LE was optimized with a simple and practical method of “Class Function/Shape Function Transformation Technique” (CST). The simulation conditions, covering the whole working range, were independently determined by incidence,...

article

Effect of Different Trench Lips on Downstream Film Cooling Effectiveness and Flow Fields

Rui Hou, Fengbo Wen, Tao Cui, Xiaolei Tang, more

Journal of Thermal Science > 2019 > 28 > 2 > 340-353

In the present study, the trenched configurations, including traditional trench (TT), fillet trench (FT) and varying-radius trench (VRT), are numerically investigated at different conditions in terms of downstream cooling effectiveness and flow fields. Different trench width and fillet radii are discussed at different blowing ratios and density ratios. Results show that the downstream lips mainly...

article

Quantitative analysis on secretion level of CDNF regulated by two key α‐helices in CDNF protein

Hao Liu, Lin Zhong, Chunling Zhao, Xiaolei Tang, more

Cell Biology International > 43 > 2 > 167 - 173

Cerebral dopamine neurotrophic factor (CDNF) has been considered as potent candidates for the therapy of Parkinson's disease (PD) for which can promote the survival of midbrain dopaminergic neurons. In addition to secret out from cells like other classical neurotrophic factors (NTFs), CDNF can locate in the endoplasmatic reticulum (ER), where they can function as ER stress response protein to regulate...

article

Nitrogen Tuned Charge Redistribution and Orbital Reconfiguration in Fe/MgO Interface for Significant Interfacial Magnetism Tunability

Shiru Wang, Mingke Yao, Zirun Li, Chun Feng, more

Advanced Functional Materials > 29 > 4 > n/a - n/a

Modulating the orbital configuration of ferromagnetic metal (FM)/metal‐oxide (MO) interfaces is crucial for obtaining a controllable interfacial magnetism for constructing energy‐efficient magnetic memory and logic devices. The traditional works of orbital regulation depend on external fields, such as electric field, temperature field, and stress field. This work proposes a novel orbital modulation...

article

Significant Strain‐Induced Orbital Reconstruction and Strong Interfacial Magnetism in TiNi(Nb)/Ferromagnet/Oxide Heterostructures via Oxygen Manipulation

Chun Feng, Shiru Wang, Li Yin, Xujing Li, more

Advanced Functional Materials > 28 > 37 > n/a - n/a

Dynamical manipulation of oxygen ion (O²⁻) at metal/oxide heterointerfaces is widely demonstrated to tailor numerous physical and chemical properties and facilitate creating novel functionalities significantly. The traditional works mainly focus on electric control of O²⁻ dynamical behavior and related interface characteristics. Here, an alternative strategy is reported to modulate O²⁻ transport and...

article

Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice

Mariam Choudry, Xiaolei Tang, Tiffany Santorian, Samiksha Wasnik, more

Immunology > 155 > 1 > 85 - 98

In the past there have been a multitude of studies that ardently support the role of arginase II (Arg II) in vascular and endothelial disorders; however, the regulation and function of Arg II in autoimmune diseases has thus far remained unclear. Here we report that a global Arg II null mutation in mice suppressed experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis...

article

Construction of FeN alloy films with ultra-strong magnetism and tunable magnetic anisotropy for spintronic application

Chun Feng, Jianjuan Yin, Jian-Gang Niu, Qinghua Zhang, more

Journal of Alloys and Compounds > 2017 > 725 > C > 32-40

FeN alloy film is a promising spintronic material with the theoretically ultra-strong magnetism (saturation magnetization M_S and magnetic anisotropy K_eff) and high spin polarization, which relies on the degree of N ordering interstice occupancy (S). However, due to the high activation energy for N ordering, the S value of an actual FeN film is mostly lower than 35% and this restricts the achievable...

article

Overcome the limitation of hypoxia against photodynamic therapy to treat cancer cells by using perfluorocarbon nanodroplet for photosensitizer delivery

Xiaolei Tang, Yuhao Cheng, Shiting Huang, Feng Zhi, more

Biochemical and Biophysical Research Communications > 2017 > 487 > 3 > 483-487

The low oxygen concentration limits the therapeutic efficacy of photodynamic therapy in treating cancer cells in hypoxia, since the cytotoxic ¹O₂ can't be effectively generated in this condition. To overcome this, we load photosensitizer into perfluorocarbon nanodroplet, which has a high oxygen capacity to enrich O₂ for photodynamic consumption. Under the well-controlled hypoxic condition, we test...

article

Application of vitamin D and vitamin D analogs in acute myelogenous leukemia

Huynh Cao, Yi Xu, Rosalia de Necochea-Campion, David J. Baylink, more

Experimental Hematology > 2017 > 50 > C > 1-12

Acute myeloid leukemia (AML) is characterized by the accumulation of malignant, transformed immature hematopoietic myeloid precursors that have lost their ability to differentiate and proliferate normally. Current treatment for AML requires intensive cytotoxic chemotherapy and results in significant morbidity and mortality, especially in older patients. Effective and better-tolerated treatment is...

article

MicroRNA223 promotes pathogenic T‐cell development and autoimmune inflammation in central nervous system in mice

Tiffany Satoorian, Bo Li, Xiaolei Tang, Jidong Xiao, more

Immunology > 148 > 4 > 326 - 338

Multiple sclerosis (MS) is an incurable central nervous system autoimmune disease. Understanding MS pathogenesis is essential for the development of new MS therapies. In the present study, we identified a novel microRNA (miR) that regulates experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Expression of miR223 was up‐regulated specifically in spinal cords and lymphoid organs...

article

Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy

Ahu Yuan, Xuefeng Qiu, Xiaolei Tang, Wei Liu, more

Biomaterials > 2015 > 51 > C > 184-193

IR-780, a representative hydrophobic near-infrared (NIR) fluorescence dye, is capable of fluorescently imaging and photothermal therapy in vitro and in vivo. However, insolubility in all pharmaceutically acceptable solvents limits its further biological applications. To increase solubility, we developed a novel self-assembled IR-780 containing micelle (PEG-IR-780-C13) based on the structural modification...

article

Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy

Chenxiao Jiang, Hao Cheng, Ahu Yuan, Xiaolei Tang, more

Acta Biomaterialia > 2015 > 14 > Complete > 61-69

It has been reported that IR780 iodide, a near-infrared dye, can be applied for cancer imaging, photodynamic therapy (PDT) and photothermal therapy (PTT). However, the hydrophobicity and toxicity of IR780 severely limit its further clinical applications. In this study, human serum albumin was used to load IR780 to form nanoparticles (HSA-IR780 NPs) by protein self-assembly. Compared to free IR-780,...

article

In Situ Floating Hydrogel for Intravesical Delivery of Adriamycin Without Blocking Urinary Tract

Tingsheng Lin, Jinhui Wu, Xiaozhi Zhao, Huibo Lian, more

Journal of Pharmaceutical Sciences > 103 > 3 > 927 - 936

Drug solution is commonly used in conventional intravesical instillation. However, most of them would be easily eliminated by voiding, which significantly limit their efficacy. Recent advances in intravesical drug delivery are to use hydrogels as drug reservoir to extend the drug residence time in bladder. However, because of the high viscosity of hydrogel, urinary obstruction is usually existed during...

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INFONA - science communication portal

Search results for: Xiaolei Tang

Beta‐mannosidosis presenting predominantly with recurrent pulmonary infections, hemorrhage, and cystic lesions

Case report of a pediatric Chinese cystic fibrosis patient with the c.1521_1523delCTT/c.3874‐4522A>G genotype

Radiofrequency catheter ablation improves long‐term prognosis and cardiac function of the patients with tachyarrhythmia‐induced cardiomyopathy

Pseudo‐Bartter syndrome in Chinese children with cystic fibrosis: Clinical features and genotypic findings

Bronchoalveolar lavage T cell cytokine profiles and their association with lung function in children with Mycoplasma pneumoniae ‐associated bronchiolitis obliterans

Cobalamin C deficiency presenting with diffuse alveolar hemorrhage and pulmonary microangiopathy

Transdermal permeation effect of collagen hydrolysates of deer sinew on mouse skin, ex vitro, and antioxidant activity, increased type I collagen secretion of percutaneous proteins in NIH/3T3 cells

Effect of Leading-Edge Optimization on the Loss Characteristics in a Low-Pressure Turbine Linear Cascade

Effect of Different Trench Lips on Downstream Film Cooling Effectiveness and Flow Fields

Quantitative analysis on secretion level of CDNF regulated by two key α‐helices in CDNF protein

Nitrogen Tuned Charge Redistribution and Orbital Reconfiguration in Fe/MgO Interface for Significant Interfacial Magnetism Tunability

Significant Strain‐Induced Orbital Reconstruction and Strong Interfacial Magnetism in TiNi(Nb)/Ferromagnet/Oxide Heterostructures via Oxygen Manipulation

Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice

Construction of FeN alloy films with ultra-strong magnetism and tunable magnetic anisotropy for spintronic application

Overcome the limitation of hypoxia against photodynamic therapy to treat cancer cells by using perfluorocarbon nanodroplet for photosensitizer delivery

Application of vitamin D and vitamin D analogs in acute myelogenous leukemia

MicroRNA223 promotes pathogenic T‐cell development and autoimmune inflammation in central nervous system in mice

Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy

Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy

In Situ Floating Hydrogel for Intravesical Delivery of Adriamycin Without Blocking Urinary Tract

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