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Aging may significantly modify antioxidant and photoprotective properties of melanin in retinal pigment epithelium (RPE). Here, photoreactivity of melanosomes (MS), isolated from younger and older human donors with and without added zeaxanthin and α‐tocopherol, was analyzed by electron paramagnetic resonance oximetry, time‐resolved singlet oxygen phosphorescence, and protein oxidation assay. The phototoxic...