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Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions...
Objective
Identifying associations among circulating proteins, dietary intakes, and clinically relevant indicators of cardiometabolic health during weight loss may elucidate biologically relevant pathways affected by diet, allowing for an incorporation of precision nutrition approaches when designing future interventions. This study hypothesized that plasma proteins would be associated with diet...
Objective
Mathematical equations that predict resting energy expenditure (REE) are widely used to derive calorie prescriptions during weight‐loss interventions. Although such equations are known to introduce group‐ and individual‐level error into REE prediction, their validity has largely been assessed in weight‐stable populations. Therefore, this study sought to characterize how weight change affects...
Objective
Identifying predictors of weight loss and clinical outcomes may increase understanding of individual variability in weight loss response. We hypothesized that baseline multiomic features, including DNA methylation (DNAme), metabolomics, and gut microbiome, would be predictive of short‐term changes in body weight and other clinical outcomes within a comprehensive weight loss intervention...
Objective
This study aimed to perform a preliminary investigation of the impact of combined hormonal contraceptive (CHC) use on weight loss during an 18‐month behavioral weight‐loss trial.
Methods
Adults (n = 170; 18‐55 years; BMI 27‐42 kg/m2) received a weight‐loss intervention that included a reduced‐calorie diet, a progressive exercise prescription, and group‐based behavioral support. Premenopausal...
Objective
This study aimed to evaluate the impact of timing of exercise initiation on weight loss within a behavioral weight loss program.
Methods
Adults with overweight or obesity (N = 170; age 18‐55 years; BMI 25‐42 kg/m2; 83.5% women) were enrolled in an 18‐month behavioral weight loss program consisting of a reduced‐calorie diet, exercise, and group‐based support. The standard group (STD) received...
Objective
The objective of this study was to compare physical activity energy expenditure (PAEE) and total daily energy expenditure (TDEE) in successful weight loss maintainers (WLM) with normal weight controls (NC) and controls with overweight/obesity (OC).
Methods
Participants were recruited in three groups: WLM (n = 25, BMI 24.1 ± 2.3 kg/m2; maintaining ≥ 13.6‐kg weight loss for ≥ 1 year),...
Objective
The objective of this study was to compare patterns of objectively measured moderate‐to‐vigorous physical activity (MVPA, ≥ 3.00 metabolic equivalents [METs]), light‐intensity physical activity (LPA, 1.50‐2.99 METs), and sedentary behavior (SB, < 1.50 METs) in successful weight loss maintainers (WLMs), normal weight controls (NC), and controls with overweight/obesity (OC).
Methods...
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