Search results for: Tomoki Arichi

Items from 1 to 20 out of 25 results

article

In vivo T₁ mapping of neonatal brain tissue at 64 mT

Francesco Padormo, Paul Cawley, Louise Dillon, Emer Hughes, more

Magnetic Resonance in Medicine > 89 > 3 > 1016 - 1025

Purpose Ultralow‐field (ULF) point‐of‐care MRI systems allow image acquisition without interrupting medical provision, with neonatal clinical care being an important potential application. The ability to measure neonatal brain tissue T₁ is a key enabling technology for subsequent structural image contrast optimization, as well as being a potential biomarker for brain development. Here we describe...

article

Neurodisability care in the time of COVID‐19

Tomoki Arichi, Jill Cadwgan, Aoife McDonald, Anita Patel, more

Child: Care, Health and Development > 48 > 6 > 901 - 905

Background The COVID‐19 pandemic resulted in an unprecedented societal and healthcare global crisis. Associated changes in regular healthcare provision and lifestyle through societal lockdown are likely to have affected clinical management and well‐being of children/young people with neurodisability, who often require complex packages of multidisciplinary care. Methods We surveyed 108 families...

article

Care in COVID: A qualitative analysis of the impact of COVID‐19 on the health and care of children and young people with severe physical neurodisability and their families

Jill Cadwgan, Jane Goodwin, Tomoki Arichi, Anita Patel, more

Child: Care, Health and Development > 48 > 6 > 924 - 934

Aim To evaluate clinicians' perspectives on the impact of ‘lockdown’ during the COVID‐19 pandemic for children and young people with severe physical neurodisability and their families. Method Framework analysis of comments from families during a recent service review was used to code the themes discussed according to the World Health Organization International Classification of Functioning, Disability...

article

Development of functional organization within the sensorimotor network across the perinatal period

Sofia Dall'Orso, Tomoki Arichi, Sean P. Fitzgibbon, A. David Edwards, more

Human Brain Mapping > 43 > 7 > 2249 - 2261

In the mature human brain, the neural processing related to different body parts is reflected in patterns of functional connectivity, which is strongest between functional homologs in opposite cortical hemispheres. To understand how this organization is first established, we investigated functional connectivity between limb regions in the sensorimotor cortex in 400 preterm and term infants aged across...

article

Effects of gestational age at birth on perinatal structural brain development in healthy term‐born babies

Oliver Gale‐Grant, Sunniva Fenn‐Moltu, Lucas G. S. França, Ralica Dimitrova, more

Human Brain Mapping > 43 > 5 > 1577 - 1589

Infants born in early term (37–38 weeks gestation) experience slower neurodevelopment than those born at full term (40–41 weeks gestation). While this could be due to higher perinatal morbidity, gestational age at birth may also have a direct effect on the brain. Here we characterise brain volume and white matter correlates of gestational age at birth in healthy term‐born neonates and their relationship...

article

Construction and validation of a database of head models for functional imaging of the neonatal brain

Liam H. Collins‐Jones, Tomoki Arichi, Tanya Poppe, Addison Billing, more

Human Brain Mapping > 42 > 3 > 567 - 586

The neonatal brain undergoes dramatic structural and functional changes over the last trimester of gestation. The accuracy of source localisation of brain activity recorded from the scalp therefore relies on accurate age‐specific head models. Although an age‐appropriate population‐level atlas could be used, detail is lost in the construction of such atlases, in particular with regard to the smoothing...

article

Complementing cooling: the ongoing search for an effective adjunct to therapeutic hypothermia

Ana A. Baburamani, Tomoki Arichi

The Journal of Physiology > 598 > 5 > 905 - 906

article

New approaches to studying early brain development in Down syndrome

Ana A Baburamani, Prachi A Patkee, Tomoki Arichi, Mary A Rutherford

Developmental Medicine & Child Neurology > 61 > 8 > 867 - 879

Down syndrome is the most common genetic developmental disorder in humans and is caused by partial or complete triplication of human chromosome 21 (trisomy 21). It is a complex condition which results in multiple lifelong health problems, including varying degrees of intellectual disability and delays in speech, memory, and learning. As both length and quality of life are improving for individuals...

article

Anticoagulation in the management of neonatal cerebral sinovenous thrombosis: a systematic review and meta‐analysis

Thomas Rossor, Tomoki Arichi, Sanjay Bhate, Anthony R Hart, more

Developmental Medicine & Child Neurology > 60 > 9 > 884 - 891

Aim To determine whether anticoagulation therapy (ACT) in the treatment of neonatal cerebral sinovenous thrombosis (CSVT) improves outcomes, in the presence or absence of pre‐existing intracerebral haemorrhage (ICH). Method We searched CENTRAL, MEDLINE, Embase, CINAHL, the Web of Science, and clinical trial databases. We considered data from retrospective and prospective cohort studies, case series,...

article

Is there predictive value in early magnetic resonance imaging of the brain in infants born preterm?

Sophie Arulkumaran, Tomoki Arichi

Developmental Medicine & Child Neurology > 60 > 2 > 116 - 116

article

A dedicated neonatal brain imaging system

Emer J. Hughes, Tobias Winchman, Francesco Padormo, Rui Teixeira, more

Magnetic Resonance in Medicine > 78 > 2 > C1 - C1

Purpose The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High‐quality imaging in this cohort without sedation presents a number of technical and practical challenges. Methods We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32‐channel receive array coil...

article

A dedicated neonatal brain imaging system

Emer J. Hughes, Tobias Winchman, Francesco Padormo, Rui Teixeira, more

Magnetic Resonance in Medicine > 78 > 2 > 794 - 804

article

Language ability in preterm children is associated with arcuate fasciculi microstructure at term

Piergiorgio Salvan, J. Donald Tournier, Dafnis Batalle, Shona Falconer, more

Human Brain Mapping > 38 > 8 > 3836 - 3847

In the mature human brain, the arcuate fasciculus mediates verbal working memory, word learning, and sublexical speech repetition. However, its contribution to early language acquisition remains unclear. In this work, we aimed to evaluate the role of the direct segments of the arcuate fasciculi in the early acquisition of linguistic function. We imaged a cohort of 43 preterm born infants (median age...

article

Bridging the gap between early corpus callosal growth and neurodevelopmental outcome in infants born very preterm

Johannes Steinweg, Tomoki Arichi

Developmental Medicine & Child Neurology > 59 > 4 > 351 - 352

article

Can neonatal MRI predict long‐term motor outcome following preterm birth?

Tomoki Arichi

Developmental Medicine & Child Neurology > 58 > 7 > 654 - 655

article

An exploration of task based fMRI in neonates using echo-shifting to allow acquisition at longer TE without loss of temporal efficiency

Giulio Ferrazzi, Rita G. Nunes, Tomoki Arichi, Andreia S. Gaspar, more

NeuroImage > 2016 > 127 > C > 298-306

Optimal contrast to noise ratio of the BOLD signal in neonatal and foetal fMRI has been hard to achieve because of the much longer T₂^⁎ values in developing brain tissue in comparison to those in the mature adult brain. The conventional approach of optimizing fMRI sequences would suggest matching the echo time (T_E) and the T₂^⁎ of the neonatal and foetal brain. However, the use of a long echo time would...

article

Regional growth and atlasing of the developing human brain

Antonios Makropoulos, Paul Aljabar, Robert Wright, Britta Hüning, more

NeuroImage > 2016 > 125 > C > 456-478

Detailed morphometric analysis of the neonatal brain is required to characterise brain development and define neuroimaging biomarkers related to impaired brain growth. Accurate automatic segmentation of neonatal brain MRI is a prerequisite to analyse large datasets. We have previously presented an accurate and robust automatic segmentation technique for parcellating the neonatal brain into multiple...

article

Resting State fMRI in the moving fetus: A robust framework for motion, bias field and spin history correction

Giulio Ferrazzi, Maria Kuklisova Murgasova, Tomoki Arichi, Christina Malamateniou, more

NeuroImage > 2014 > 101 > Complete > 555-568

There is growing interest in exploring fetal functional brain development, particularly with Resting State fMRI. However, during a typical fMRI acquisition, the womb moves due to maternal respiration and the fetus may perform large-scale and unpredictable movements. Conventional fMRI processing pipelines, which assume that brain movements are infrequent or at least small, are not suitable. Previous...

article

Pharmacokinetics of melatonin in preterm infants

Nazakat M. Merchant, Denis V. Azzopardi, Ahmed F. Hawwa, James C. McElnay, more

British Journal of Clinical Pharmacology > 76 > 5 > 725 - 733

AimsPreterm infants are deprived of the normal intra‐uterine exposure to maternal melatonin and may benefit from replacement therapy. We conducted a pharmacokinetic study to guide potential therapeutic trials. MethodsMelatonin was administered to 18 preterm infants in doses ranging from 0.04–0.6 μg kg⁻¹ over 0.5–6 h. Pharmacokinetic profiles were analyzed individually and by population methods. ...

article

The influence of preterm birth on the developing thalamocortical connectome

Gareth Ball, James P. Boardman, Paul Aljabar, Anand Pandit, more

Cortex > 2013 > 49 > 6 > 1711-1721

Defining connectivity in the human brain signifies a major neuroscientific goal. Advanced imaging techniques have enabled the non-invasive tracing of brain networks to define the human connectome on a millimetre-scale. During early development, the brain undergoes significant changes that are likely represented in the developing connectome, and preterm birth represents a significant environmental...

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INFONA - science communication portal

Search results for: Tomoki Arichi

In vivo T₁ mapping of neonatal brain tissue at 64 mT

Neurodisability care in the time of COVID‐19

Care in COVID: A qualitative analysis of the impact of COVID‐19 on the health and care of children and young people with severe physical neurodisability and their families

Development of functional organization within the sensorimotor network across the perinatal period

Effects of gestational age at birth on perinatal structural brain development in healthy term‐born babies

Construction and validation of a database of head models for functional imaging of the neonatal brain

Complementing cooling: the ongoing search for an effective adjunct to therapeutic hypothermia

New approaches to studying early brain development in Down syndrome

Anticoagulation in the management of neonatal cerebral sinovenous thrombosis: a systematic review and meta‐analysis

Is there predictive value in early magnetic resonance imaging of the brain in infants born preterm?

A dedicated neonatal brain imaging system

A dedicated neonatal brain imaging system

Language ability in preterm children is associated with arcuate fasciculi microstructure at term

Bridging the gap between early corpus callosal growth and neurodevelopmental outcome in infants born very preterm

Can neonatal MRI predict long‐term motor outcome following preterm birth?

An exploration of task based fMRI in neonates using echo-shifting to allow acquisition at longer TE without loss of temporal efficiency

Regional growth and atlasing of the developing human brain

Resting State fMRI in the moving fetus: A robust framework for motion, bias field and spin history correction

Pharmacokinetics of melatonin in preterm infants

The influence of preterm birth on the developing thalamocortical connectome

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