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Background and Aims
Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a master regulator of reactive oxygen species (ROS) and inflammation and has been implicated in both human and murine inflammatory disease models. We aimed to characterize the roles of macrophage‐specific Nrf2 in liver ischemia/reperfusion injury (IRI).
Approach and Results
First, macrophage Nrf2 expression and liver injury...
Notch signaling plays an emerging role in the regulation of immune cell development and function during inflammatory response. Activation of the ras homolog gene family member A/Rho‐associated protein kinase (ROCK) pathway promotes leukocyte accumulation in tissue injury. However, it remains unknown whether Notch signaling regulates ras homolog gene family member A/ROCK–mediated immune responses in...
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