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The purpose of our research was to test the hypothesis that silk protein hydrolysate increases glucose uptake in cultured murine embryonic fibroblasts. Insulin sensitizing activity was observed in a cell-based glucose uptake assay using 3T3-L1 embryonic fibroblasts. The treatment of 1 mg/mL of silk peptide E5K6 plus 0.2 nM insulin was associated with a significant increase in glucose uptake (124.0%...
The hypothesis for the research is that hydrolyzed silk protein has an antidiabetic effect by reducing plasma glucose levels. To investigate this potential antidiabetic activity of hydrolyzed silk protein by protease-N (silk protein hydrolysate E5K6) in vivo, male C57BL/KsJ-db/db mice were separated into 3 groups: control group, db/db mice treated with vehicle (distilled water); SP-1 group, db/db...
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