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The cortical organization of swallowing has been mainly studied in young and healthy subjects. Aging effects on human deglutition have been found in several behavioral studies and are known to affect both the oral and pharyngeal phases of swallowing. The aim of this study was to evaluate a potential cortical compensation of age-related swallowing impairment. Whole-head MEG was employed in 9 healthy...
ABSTRACT
BACKGROUNDKennedy disease (KD) clinically presents as progressive lower motor neuron disease with minimal or no sensory impairment. However, electrophysiological studies found abnormal somatosensory‐evoked potentials even in absence of clinical deficits. Little is known about possible influences of this sensory neuropathy on the central somatosensory processing.
METHODSIn this study, the cortical topography of index finger representation was studied in 7 patients with genetically proven KD compared to healthy control subjects by means of magnetoencephalography using an established stimulation paradigm. Data analysis was carried out with synthetic aperture magnetometry (SAM). Additionally, the latency and source amplitude of the earliest cortical somatosensory‐evoked field (SEF) component were determined based on traditional single dipole source analysis....
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