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Deer antlers are the only mammalian appendages to display an annual cycle of full regeneration. However, little is known about the molecular mechanisms of antler regeneration. Our previous study has demonstrated that parathyroid hormone‐related peptide (PTHrP) can promote proliferation of antler chondrocytes and inhibit its differentiation, but the mechanism underlying such regulation is not fully...
Ca 2+ mobilization induced by ATP, isoproterenol and the Ca 2+ -ATPase inhibitor thapsigargin in the human submandibular duct cell line A253 was investigated using the Ca 2+ -sensitive fluorescent indicator fura-2. ATP and isoproterenol increased cytosolic free Ca 2+ ([Ca 2+ ] i ) and subsequent exposure to thapsigargin after ATP or isoproterenol stimulation...
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