Olga Mazuryk

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Bioinorganic antimicrobial strategies in the resistance era

Anna Regiel-Futyra, Janusz M. Dąbrowski, Olga Mazuryk, Klaudyna Śpiewak, more

Coordination Chemistry Reviews > 2017 > 351 > C > 76-117

The emergence of Multi-Drug-Resistant (MDR) organisms has become a major worldwide clinical problem. The extensive and routine use of the first-line antibiotics to control infections imposed the development of multiple mechanisms of microbial resistance. Despite the fact that numerous advanced technologies enable the molecular design of new antibiotics, the MDR-associated infections remain a great...

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Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

Iwona Stawoska, Waldemar Tejchman, Olga Mazuryk, Antonín Lyčka, more

Journal of Heterocyclic Chemistry > 54 > 5 > 2889 - 2897

Selected rhodanine‐3‐carboxylic acids derivatives were synthesized to determine the influence of the structure and the length of the linker between the carboxyl group and the nitrogen atom (N‐3) in the 2‐thioxo‐4‐thiazolidinone ring on their activity, monitored via interactions with human serum albumin. Based on fluorescence studies, we concluded that the length of the linker has a limited impact...

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Nitroimidazole derivatives of polypyridyl ruthenium complexes: Towards understanding their anticancer activity and mode of action

Olga Mazuryk, Oksana Krysiak-Foria, Agnieszka Żak, Franck Suzenet, more

European Journal of Pharmaceutical Sciences > 2017 > 101 > C > 43-55

The mechanism of cell death induced by the ruthenium polypyridyl complexes comprising two 4,7-diphenyl-1,10-phenanthroline ligands as well as one unmodified 2,2′-bipyridyl or modified with 2-nitroimidazole moiety attached by shorter (C₃H₆) or longer (C₆H₁₂) linker was investigated. Cytotoxicity and proliferation assays revealed that the studied Ru polypyridyl complexes are more toxic against human...

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Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Janusz M. Dąbrowski, Barbara Pucelik, Anna Regiel-Futyra, Małgorzata Brindell, more

Coordination Chemistry Reviews > 2016 > 325 > C > 67-101

Applications of metalloporphyrins and related molecules have been extensively pursued in the context of photodynamic therapy of cancer (PDT) and other biomedical applications. This review discusses photophysical and photochemical properties of metalloporphyrins and their analogues, such as metallochlorins, metallobacteriochlorins and metallophthalocyanines that are relevant for photodynamic processes...

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Anticancer activity of ruthenium(II) polypyridine complexes bearing pyrrolidine substituents

Olga Mazuryk, Michał Łomzik, David Martineau, Marc Beley, more

Inorganica Chimica Acta > 2016 > 443 > C > 86-90

A set of homoleptic ruthenium polypyridine (bipyridine and terpyridine) complexes flanked with several electron-donating pyrrolidine moieties has been characterized and the anticancer activity was evaluated toward human lung adenocarcinoma epithelial (A549) and murine colon carcinoma (CT26). Good antiproliferative effects were observed with an IC₅₀ ranging from ca. 4 to 21μM against both cell lines...

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2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization

Olga Mazuryk, Monika Maciuszek, Grażyna Stochel, Franck Suzenet, more

Journal of Inorganic Biochemistry > 2014 > 134 > Complete > 83-91

A novel long-lifetime highly luminescent ruthenium polypyridyl complex containing 2-nitroimidazole moiety [Ru(dip) ₂ (bpy-2-nitroIm)]Cl ₂ (dip=4,7-diphenyl-1,10-phenanthroline, bpy-2-nitroIm=4-[3-(2-nitro-1H-imidazol-1-yl)propyl]-2,2′-bipyridine) has been designed cancer treatment and imaging. The luminescence properties of the synthesized compound strongly depend on the oxygen concentration...

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Multifaceted interplay between lipophilicity, protein interaction and luminescence parameters of non-intercalative ruthenium(II) polypyridyl complexes controlling cellular imaging and cytotoxic properties

Olga Mazuryk, Katarzyna Magiera, Barbara Rys, Franck Suzenet, more

JBIC Journal of Biological Inorganic Chemistry > 2014 > 19 > 8 > 1305-1316

Here, we examine the photophysical properties of five ruthenium(II) complexes comprising two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and functionalized bipyridine (R₁bpy-R₂, where R₁ = H or CH₃, R₂ = H, CH₃, COO⁻,4-[3-(2-nitro-1H-imidazol-1-yl)propyl] or 1,3-dicyclohexyl-1-carbonyl-urea) towards development of luminescence probes for cellular imaging. These complexes have been shown to interact...

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Benzothiophen-pyrazine scaffold as a potential membrane targeting drug carrier

Olga Mazuryk, Elżbieta Niemiec, Grażyna Stochel, Isabelle Gillaizeau, more

Journal of Luminescence > 2013 > 140 > Complete > 51-56

The fluorescent properties of 2,5-di(benzo[b]thiophen-2-yl)pyrazine as a potential membrane targeting drug carrier were characterized and it was shown that its fluorescence intensity was much higher in organic solvent than in water. The embedding of studied compound by liposomes leads to ca. 2 orders of magnitude increase in its fluorescence intensity, suggesting its preferential accumulation in membranes...

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Interaction of apo-transferrin with anticancer ruthenium complexes NAMI-A and its reduced form

Olga Mazuryk, Katarzyna Kurpiewska, Krzysztof Lewiński, Grażyna Stochel, more

Journal of Inorganic Biochemistry > 2012 > 116 > Complete > 11-18

NAMI-A i.e. (ImH)[trans-RuCl ₄ (DMSO)(Im)] (where Im is imidazole) is a ruthenium(III) complex with promising antimetastatic activity, which has been classified for II phase clinical trial. In this study, its binding properties toward apo-transferrin (apo-Tf) with regard to its hydrolytic and redox behavior are systematically investigated by the use of fluorescence spectroscopy. The reaction...

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Search results for: Olga Mazuryk

Bioinorganic antimicrobial strategies in the resistance era

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

Nitroimidazole derivatives of polypyridyl ruthenium complexes: Towards understanding their anticancer activity and mode of action

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Anticancer activity of ruthenium(II) polypyridine complexes bearing pyrrolidine substituents

2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization

Multifaceted interplay between lipophilicity, protein interaction and luminescence parameters of non-intercalative ruthenium(II) polypyridyl complexes controlling cellular imaging and cytotoxic properties

Benzothiophen-pyrazine scaffold as a potential membrane targeting drug carrier

Interaction of apo-transferrin with anticancer ruthenium complexes NAMI-A and its reduced form

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