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Die biologische Aktivität einer triplexbildenden Peptidnucleinsäure (PNA), die nichtnatürliche Nucleobasen enthält, wird von N. Sugimoto et al. in der Zuschrift auf S. 911 ff. untersucht. Der Triplex zwischen der PNA und der 5′‐untranslatierten Region der mRNA reduziert die sequenzspezifische Proteinexpression in vitro und in Zellen, da die Progression der kleinen ribosomalen Untereinheit blockiert...
Compounds that bind specifically to double‐stranded regions of RNA have potential as regulators of structure‐based RNA function; however, sequence‐selective recognition of double‐stranded RNA is challenging. The modification of peptide nucleic acid (PNA) with unnatural nucleobases enables the formation of PNA–RNA triplexes. Herein, we demonstrate that a 9‐mer PNA forms a sequence‐specific PNA–RNA...
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