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Non‐coding RNAs play important roles in cellular homeostasis and are involved in many human diseases including cancer. Intermolecular RNA–RNA interactions are the basis for the diverse functions of many non‐coding RNAs. Herein, we show how the presence of tRNA influences the equilibrium between hairpin and G‐quadruplex conformations in the 5′ untranslated regions of oncogenes and model sequences....
Transfer‐RNA ändert die mRNA‐Konformation! In ihrer Zuschrift auf S. 14527 ff. zeigen N. Sugimoto und Mitarbeiter, dass onkogene mRNAs durch Einwirkung von tRNA von einer G‐Quadruplex(G4)‐ in eine Haarnadel‐Konformation übergehen. tRNA, eine zelluläre nichtkodierende RNA, ist in Krebszellen überexprimiert. Die verminderte G4‐vermittelte Translationssuppression infolge der mRNA‐Konformationsänderung...
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