Search results for: Paweł Wiczling

Items from 1 to 20 out of 41 results

article

Population Pharmacokinetic Model of Dexmedetomidine in a Heterogeneous Group of Patients

Justyna Ber, Paweł Wiczling, Marcin Hołysz, Agnieszka Klupczyńska, more

The Journal of Clinical Pharmacology > 60 > 11 > 1461 - 1473

Dexmedetomidine is a hepatically eliminated drug with sedative, anxiolytic, sympatholytic, and analgesic properties that has been increasingly used for various indications in the form of a short or continuous intravenous infusion. This study aimed to propose a population pharmacokinetic (PK) model of dexmedetomidine in a heterogeneous group of intensive care unit patients, incorporating 29 covariates...

article

Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits

Justyna Warzybok, Agnieszka Bienert, Agnieszka Borsuk‐De Moor, Włodzimierz Płotek, more

Biopharmaceutics & Drug Disposition > 41 > 7 > 307 - 316

The purpose of this work was i) to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model of dexmedetomidine (DEX) in New Zealand White rabbits, ii) to investigate the influence of the age and weight of the animals on the model parameters, and iii) to assess the linearity of DEX PKs in the examined dose range. This was a prospective, crossover study, using a total of 18 New Zealand...

article

Hydroxycarbamide in children with sickle cell anaemia after first‐dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure

Jeremie H. Estepp, Paweł Wiczling, Joseph Moen, Guolian Kang, more

British Journal of Clinical Pharmacology > 84 > 7 > 1478 - 1485

Aims The purposes of this work were to: (1) compare pharmacokinetic (PK) parameters for hydroxycarbamide in children receiving their first dose (HC_new) vs. those receiving chronic therapy (HC_chronic), (2) assess the external validity of a published PK dosing strategy, and (3) explore the accuracy of dosing strategies based on a limited number of HC measurements. Methods Utilizing data from two...

article

Ionization of tocopherols and tocotrienols in atmospheric pressure chemical ionization

Ewa Bartosińska, Agnieszka Borsuk‐De Moor, Danuta Siluk, Michał J. Markuszewski, more

Rapid Communications in Mass Spectrometry > 32 > 11 > 919 - 927

Rationale Tocopherols and tocotrienols are chemical compounds insusceptible to the ionization process under atmospheric pressure conditions. Therefore, the selection of the optimal ion source settings for their quantification requires special attention. The aim of this study was to analyse the influence of the APCI source parameters on the response of tocochromanols and two related compounds. Methods...

article

Analyzing chromatographic data using multilevel modeling

Paweł Wiczling

Analytical and Bioanalytical Chemistry > 2018 > 410 > 16 > 3905-3915

It is relatively easy to collect chromatographic measurements for a large number of analytes, especially with gradient chromatographic methods coupled with mass spectrometry detection. Such data often have a hierarchical or clustered structure. For example, analytes with similar hydrophobicity and dissociation constant tend to be more alike in their retention than a randomly chosen set of analytes...

article

Pharmacokinetics of dexmedetomidine during analgosedation in ICU patients

Piotr Smuszkiewicz, Paweł Wiczling, Justyna Ber, Justyna Warzybok, more

Journal of Pharmacokinetics and Pharmacodynamics > 2018 > 45 > 2 > 277-284

Dexmedetomidine (DEX) is a fairly new alfa₂-agonist which has been increasingly used in recent years for analgosedation, mostly because it offers a unique ability of providing both moderate level of sedation and analgesia without respiratory depression. Despite of many papers published, there are still only a few concerning the PK of the drug given as long-term infusion in ICU patients. The aim of...

article

How to model temporal changes in nontargeted metabolomics study? A Bayesian multilevel perspective

Paweł Wiczling, Emilia Daghir‐Wojtkowiak, Arlette Yumba Mpanga, Damian Szczesny, more

Journal of Separation Science > 40 > 24 > 4667 - 4676

Analysis of time series data addresses the question on mechanisms underlying normal physiology and its alteration under pathological conditions. However, adding time variable to high‐dimension, collinear, noisy data is a challenge in terms of mining and analysis. Here, we used Bayesian multilevel modeling for time series metabolomics in vivo study to model different levels of random effects occurring...

article

Overview of experimental and computational methods for the determination of the pKa values of 5-fluorouracil, cyclophosphamide, ifosfamide, imatinib and methotrexate

Katarzyna Mioduszewska, Joanna Dołżonek, Dariusz Wyrzykowski, Łukasz Kubik, more

TrAC Trends in Analytical Chemistry > 2017 > 97 > C > 283-296

We present a review of the available literature concerning pKa values and methods for the determination of selected anticancer drugs as well as the most up-to-date knowledge on their different ionic forms depending on solution pH. Additionally, to clarify the existing state of knowledge we have presented an overview on the obtained pKa values with the use of experimental and computational methods...

article

Flip‐Flop Phenomenon in Epidural Sufentanil Pharmacokinetics: A Population Study in Children and Infants

Agnieszka Borsuk, Bogumiła Wołoszczuk‐Gębicka, Alicja Bartkowska‐Śniatkowska, Jowita Rosada‐Kurasińska, more

The Journal of Clinical Pharmacology > 57 > 9 > 1194 - 1206

The aims of this study were to develop a population pharmacokinetic model of sufentanil coadministered with 0.2% ropivacaine as an epidural infusion in infants and describe the sufentanil absorption profile from epidural space. Data from 2 previously published studies were merged for analysis—20 infants aged 3–36 months receiving sufentanil as an epidural infusion and 41 children 0–17 years old receiving...

article

Age-structured population model of cell survival

Wojciech Krzyzanski, Pawel Wiczling, Asfiha Gebre

Journal of Pharmacokinetics and Pharmacodynamics > 2017 > 44 > 4 > 305-316

Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and random labeling cell survival data. In addition, it accounts for cell loss due to...

article

Multilevel pharmacokinetics-driven modeling of metabolomics data

Emilia Daghir-Wojtkowiak, Paweł Wiczling, Małgorzata Waszczuk-Jankowska, Roman Kaliszan, more

Metabolomics > 2017 > 13 > 3 > 1-13

Introduction Multilevel modeling is a quantitative statistical method to investigate variability and relationships between variables of interest, taking into account population structure and dependencies. It can be used for prediction, data reduction and causal inference from experiments and observational studies allowing for more efficient elucidation of knowledge. Objectives In this study we introduced...

article

The pharmacokinetics of propofol in ICU patients undergoing long‐term sedation

Piotr Smuszkiewicz, Paweł Wiczling, Krzysztof Przybyłowski, Agnieszka Borsuk, more

Biopharmaceutics & Drug Disposition > 37 > 8 > 456 - 466

The aim of this study was to characterize the pharmacokinetics (PK) of propofol in ICU patients undergoing long‐term sedation and to assess the influence of routinely collected covariates on the PK parameters. Propofol concentration–time profiles were collected from 29 patients. Non‐linear mixed‐effects modelling in NONMEM 7.2 was used to analyse the observed data. The propofol pharmacokinetics was...

article

Quantitative structure-(chromatographic) retention relationship models for dissociating compounds

Łukasz Kubik, Paweł Wiczling

Journal of Pharmaceutical and Biomedical Analysis > 2016 > 127 > C > 176-183

The aim of this work was to develop mathematical models relating the hydrophobicity and dissociation constant of an analyte with its structure, which would be useful in predicting analyte retention times in reversed-phase liquid chromatography. For that purpose a large and diverse group of 115 drugs was used to build three QSRR models combining retention-related parameters (logk_w—chromatographic measure...

article

Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia

Jeremie H. Estepp, Chiara Melloni, Courtney D. Thornburg, Paweł Wiczling, more

The Journal of Clinical Pharmacology > 56 > 3 > 298 - 306

Hydroxyurea (HU) is a crucial therapy for children with sickle cell anemia, but its off‐label use is a barrier to widespread acceptance. We found HU exposure is not significantly altered by liquid vs capsule formulation, and weight‐based dosing schemes provide consistent exposure. HU is recommended for all children starting as young as 9 months of age with sickle cell anemia (SCA; HbSS and HbSβspan...

article

The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors

Paweł Wiczling, Alicja Bartkowska-Śniatkowska, Oliwia Szerkus, Danuta Siluk, more

Journal of Pharmacokinetics and Pharmacodynamics > 2016 > 43 > 3 > 315-324

The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using the Bayesian population modeling with literature-based informative priors. Thirty-eight patients were included in the analysis with concentration measurements obtained at two occasions: first from 0 to 24 h after...

article

Pharmacokinetics of sufentanil during long‐term infusion in critically ill pediatric patients

Alicja Bartkowska‐Śniatkowska, Agnieszka Bienert, Paweł Wiczling, Jowita Rosada‐Kurasińska, more

The Journal of Clinical Pharmacology > 56 > 1 > 109 - 115

The aim of this study was to develop a population pharmacokinetic model of sufentanil and to assess the influence of covariates in critically ill children admitted to a pediatric intensive care unit. After institutional approval, 41 children were enrolled in the study. Blood samples for pharmacokinetic (PK) assessment were collected from routinely placed arterial catheters during and after discontinuation...

article

Simultaneous determination of hydrophobicity and dissociation constant for a large set of compounds by gradient reverse phase high performance liquid chromatography–mass spectrometry technique

Łukasz Kubik, Wiktoria Struck-Lewicka, Roman Kaliszan, Paweł Wiczling

Journal of Chromatography A > 2015 > 1416 > Complete > 31-37

Fast and reliable methods for the determination of hydrophobicity and acidity are desired in pre-clinical drug development phases to eliminate compounds with poor pharmacokinetic properties. Reversed-phase high-performance liquid chromatography (RP HPLC) coupled with time-of-flight mass spectrometry (RP HPLC–ESI-TOF–MS) is a convenient technique for that purpose. In this work we determined the chromatographic...

article

Least absolute shrinkage and selection operator and dimensionality reduction techniques in quantitative structure retention relationship modeling of retention in hydrophilic interaction liquid chromatography

Emilia Daghir-Wojtkowiak, Paweł Wiczling, Szymon Bocian, Łukasz Kubik, more

Journal of Chromatography A > 2015 > 1403 > Complete > 54-62

The objective of this study was to model the retention of nucleosides and pterins in hydrophilic interaction liquid chromatography (HILIC) via QSRR-based approach.Two home-made (Amino-P-C18, Amino-P-C10) and one commercial (IAM.PC.DD2) HILIC stationary phases were considered. Logarithm of retention factor at 5% of acetonitrile (logk _ACN ) along with descriptors obtained for 16 nucleosides...

article

Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery

Krzysztof Przybyłowski, Joanna Tyczka, Damian Szczesny, Agnieszka Bienert, more

Journal of Pharmacokinetics and Pharmacodynamics > 2015 > 42 > 2 > 111-122

Despite the growing number of cancer cases and cancer surgeries around the world, the pharmacokinetics (PK) and pharmacodynamics (PD) of anesthetics used in this population are poorly understood. Patients operated due to cancer are usually in severe state and often require chemotherapy. It might affect the PK/PD of drugs used in this population. Therefore, in this study we explored the PK/PD...

article

The quantification of reticulocyte maturation and neocytolysis in normal and erythropoietin stimulated rats

Paweł Wiczling, Wojciech Krzyzanski, Natalia Żychlińska, Krzysztof Lewandowski, more

Biopharmaceutics & Drug Disposition > 35 > 6 > 330 - 340

A technique has recently been proposed for obtaining the reticulocyte (RET) age distribution from the flow cytometric reticulocyte count. It allows for a quantitative characterization of reticulocyte dynamics. In this work this technique was applied to characterize the blood, bone marrow and spleen reticulocytes in homeostatic and erythropoietically stimulated rats in order to determine the reticulocyte...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Paweł Wiczling

Population Pharmacokinetic Model of Dexmedetomidine in a Heterogeneous Group of Patients

Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits

Hydroxycarbamide in children with sickle cell anaemia after first‐dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure

Ionization of tocopherols and tocotrienols in atmospheric pressure chemical ionization

Analyzing chromatographic data using multilevel modeling

Pharmacokinetics of dexmedetomidine during analgosedation in ICU patients

How to model temporal changes in nontargeted metabolomics study? A Bayesian multilevel perspective

Overview of experimental and computational methods for the determination of the pKa values of 5-fluorouracil, cyclophosphamide, ifosfamide, imatinib and methotrexate

Flip‐Flop Phenomenon in Epidural Sufentanil Pharmacokinetics: A Population Study in Children and Infants

Age-structured population model of cell survival

Multilevel pharmacokinetics-driven modeling of metabolomics data

The pharmacokinetics of propofol in ICU patients undergoing long‐term sedation

Quantitative structure-(chromatographic) retention relationship models for dissociating compounds

Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia

The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors

Pharmacokinetics of sufentanil during long‐term infusion in critically ill pediatric patients

Simultaneous determination of hydrophobicity and dissociation constant for a large set of compounds by gradient reverse phase high performance liquid chromatography–mass spectrometry technique

Least absolute shrinkage and selection operator and dimensionality reduction techniques in quantitative structure retention relationship modeling of retention in hydrophilic interaction liquid chromatography

Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery

The quantification of reticulocyte maturation and neocytolysis in normal and erythropoietin stimulated rats

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Paweł Wiczling

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options