Search results for: Ahmed Toosy

Items from 1 to 8 out of 8 results

article

Iatrogenic cerebral amyloid angiopathy in older adults

Larysa Panteleienko, Dermot Mallon, Rupert Oliver, Ahmed Toosy, more

European Journal of Neurology > 31 > 6 > n/a - n/a

Background and purpose An increasing number of cases of iatrogenic cerebral amyloid angiopathy (CAA) have now been reported worldwide. Proposed diagnostic criteria require a history of medical intervention with potential for amyloid‐β transmission, for example those using cadaveric dura mater or requiring instrumentation of the brain or spinal cord. Clinical presentation occurs after an appropriate...

article

Automated detection of hyperreflective foci in the outer nuclear layer of the retina

Mathias Falck Schmidt, Jakob Lønborg Christensen, Vedrana Andersen Dahl, Ahmed Toosy, more

Acta Ophthalmologica > 101 > 2 > 200 - 206

Purpose Hyperreflective foci are poorly understood transient elements seen on optical coherence tomography (OCT) of the retina in both healthy and diseased eyes. Systematic studies may benefit from the development of automated tools that can map and track such foci. The outer nuclear layer (ONL) of the retina is an attractive layer in which to study hyperreflective foci as it has no fixed hyperreflective...

article

SENSE EPI reconstruction with 2D phase error correction and channel‐wise noise removal

Elizabeth Powell, Torben Schneider, Marco Battiston, Francesco Grussu, more

Magnetic Resonance in Medicine > 88 > 5 > 2157 - 2166

Purpose To develop a robust reconstruction pipeline for EPI data that enables 2D Nyquist phase error correction using sensitivity encoding without incurring major noise artifacts in low SNR data. Methods SENSE with 2D phase error correction (PEC‐SENSE) was combined with channel‐wise noise removal using Marcenko–Pastur principal component analysis (MPPCA) to simultaneously eliminate Nyquist ghost...

article

MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study

Ayman Tourbah, Olivier Gout, Alain Vighetto, Véronique Deburghgraeve, more

CNS Drugs > 2018 > 32 > 7 > 661-672

Background Chronic visual loss is a disabling feature in patients with multiple sclerosis (MS). It was recently shown that MD1003 (high-dose pharmaceutical-grade biotin or hdPB) may improve disability in patients with progressive MS. Objective The aim of this study was to evaluate whether MD1003 improves vision compared with placebo in MS patients with chronic visual loss. Methods The MS-ON was...

article

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

Axel Petzold, Laura J Balcer, Peter A Calabresi, Fiona Costello, more

The Lancet Neurology > 2017 > 16 > 10 > 797-812

Structural retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction of spectral domain optical coherence tomography (SD-OCT), supervised automated segmentation of individual retinal layers is possible. We aimed to investigate which retinal layers show atrophy associated with neurodegeneration in...

article

Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial

Rhian Raftopoulos, Simon J Hickman, Ahmed Toosy, Basil Sharrack, more

The Lancet Neurology > 2016 > 15 > 3 > 259-269

Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can damage vision through neurodegeneration in the optic nerve and in its fibres in the retina. Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis.We...

article

A novel approach with “skeletonised MTR” measures tract‐specific microstructural changes in early primary‐progressive MS

Benedetta Bodini, Mara Cercignani, Ahmed Toosy, Nicola De Stefano, more

Human Brain Mapping > 35 > 2 > 723 - 733

We combined tract‐based spatial statistics (TBSS) and magnetization transfer (MT) imaging to assess white matter (WM) tract‐specific short‐term changes in early primary‐progressive multiple sclerosis (PPMS) and their relationships with clinical progression. Twenty‐one PPMS patients within 5 years from onset underwent MT and diffusion tensor imaging (DTI) at baseline and after 12 months. Patients'...

article

Dissecting structure–function interactions in acute optic neuritis to investigate neuroplasticity

Thomas Jenkins, Olga Ciccarelli, Ahmed Toosy, Katherine Miszkiel, more

Human Brain Mapping > 31 > 2 > 276 - 286

Structural MRI, electrophysiology, and functional MRI (fMRI) elucidate different aspects of damage and repair in demyelinating diseases. We combined them to investigate why patients with optic neuritis (ON) exhibit a wide variation in severity of acute visual loss, with the following objectives: (1) To determine how structural and electrophysiological changes in the anterior and posterior visual pathways...

Filter options

Publication date

Last year (1)
Last 3 years (3)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

DIFFUSION (2)
AMYLOID‐Β (1)
CADAVERIC DURA MATER (1)
CONVOLUTIONAL NEURAL NETWORK (1)
CUNEUS (1)
DENOISING (1)
DORSAL STREAM (1)
EPI (1)
HYPERREFLECTIVE FOCI (1)
IATROGENIC CEREBRAL AMYLOID ANGIOPATHY (1)
MAGNETIZATION TRANSFER IMAGING (1)
MRI (1)
NEUROSURGERY (1)
NYQUIST GHOST (1)
OPTICAL COHERENCE TOMOGRAPHY (1)
OUTER NUCLEAR LAYER OF THE RETINA (1)
PLASTICITY (1)
PRIMARY‐PROGRESSIVE MULTIPLE SCLEROSIS (1)
PRION (1)
SENSE (1)
TRACT‐BASED SPATIAL STATISTICS (1)
more

Data set

Wiley (5)
Elsevier (2)
Springer (1)

INFONA - science communication portal

Search results for: Ahmed Toosy

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options