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Techniques like the hanging-drop method allow cells to form organotypic microtissues. To apply more complex three-dimensional cell model systems for drug discovery, optical analysis technologies are mandatory to assess the biological response of substances. In this study we describe the analysis of a spherical colon cancer microtissue model with a high content analysis platform. Beside the analysis...
Recently, amplification of PPFIA1, encoding a member of the liprin family located about 600 kb telomeric to CCND1 on chromosome band 11q13, was described in squamous cell carcinoma of head and neck. Because 11q13 amplification is frequent in breast cancer, and PPFIA1 has been suggested to contribute to mammary gland development, we hypothesized that PPFIA1 might also be involved in the 11q13 amplicon...
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